T
Thorgeir E. Thorgeirsson
Researcher at deCODE genetics
Publications - 121
Citations - 22357
Thorgeir E. Thorgeirsson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 49, co-authored 106 publications receiving 18623 citations. Previous affiliations of Thorgeir E. Thorgeirsson include Lawrence Berkeley National Laboratory & University of California, Santa Cruz.
Papers
More filters
Journal ArticleDOI
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tõnu Esko,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew C. Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Tönjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +122 more
TL;DR: A genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption among 12 population-based samples of European ancestry finds a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples and finds a regulator of alcohol consumption.
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tonu Esk,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Toenjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James F. Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +115 more
Journal ArticleDOI
Brain age prediction using deep learning uncovers associated sequence variants
Benedikt Atli Jónsson,Benedikt Atli Jónsson,Gyda Bjornsdottir,Thorgeir E. Thorgeirsson,Lotta Maria Ellingsen,G. Bragi Walters,G. Bragi Walters,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Magnus O. Ulfarsson,Magnus O. Ulfarsson +13 more
TL;DR: A new deep learning approach to predict brain age from a T1-weighted MRI is presented and a GWAS of the difference between predicted and chronological age is carried out, revealing two associated variants.
Journal ArticleDOI
Recombination rate and reproductive success in humans
Augustine Kong,John Barnard,Daniel F. Gudbjartsson,Gudmar Thorleifsson,Gudrun M. Jonsdottir,Sigrun Sigurdardottir,Bjorgvin Richardsson,Jonina Jonsdottir,Thorgeir E. Thorgeirsson,Michael L. Frigge,Neil E. Lamb,Stephanie L. Sherman,Jeffrey R. Gulcher,Kari Stefansson +13 more
TL;DR: This work examined genome-wide microsatellite data for 23,066 individuals, providing information on recombination events of 14,140 maternal and paternal meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age.
Journal ArticleDOI
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
Lambertus A. Kiemeney,Patrick Sulem,Søren Besenbacher,Sita H. Vermeulen,Asgeir Sigurdsson,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Simon N. Stacey,Julius Gudmundsson,Carlo Zanon,Jelena Kostic,Gisli Masson,Hjordis Bjarnason,Stefan T Palsson,Oskar B Skarphedinsson,Sigurjon A. Gudjonsson,J. Alfred Witjes,Anne J. Grotenhuis,Gerald W. Verhaegh,D. Timothy Bishop,Sei C. Sak,Ananya Choudhury,Faye Elliott,Jennifer H. Barrett,Carolyn D. Hurst,Petra J. de Verdier,Charlotta Ryk,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Paolo Vineis,Paolo Vineis,Silvia Polidoro,Silvia Polidoro,Simonetta Guarrera,Simonetta Guarrera,Carlotta Sacerdote,Marcello Campagna,Donatella Placidi,Cecilia Arici,Maurice P. Zeegers,Maurice P. Zeegers,Eliane Kellen,Berta Saez Gutierrez,José I Sanz-Velez,Manuel Sanchez-Zalabardo,Gabriel Valdivia,Maria D. Garcia-Prats,Jan G. Hengstler,Meinolf Blaszkewicz,Holger Dietrich,Roel A. Ophoff,Roel A. Ophoff,Leonard H. van den Berg,Kristin Alexiusdottir,Kristleifur Kristjansson,Gudmundur Geirsson,Sigfus Nikulasson,Vigdis Petursdottir,Augustine Kong,Thorgeir E. Thorgeirsson,N. Aydin Mungan,Annika Lindblom,Michael A. van Es,Stefano Porru,Frank Buntinx,Frank Buntinx,Klaus Golka,Jose I. Mayordomo,Rajesh Kumar,Giuseppe Matullo,Giuseppe Matullo,Gunnar Steineck,Gunnar Steineck,Anne E. Kiltie,Katja K H Aben,Eirikur Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Margaret A. Knowles,Thorunn Rafnar,Kari Stefansson,Kari Stefansson +82 more
TL;DR: The results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC, and Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low- grade stage Ta tumors.