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Thorgeir E. Thorgeirsson

Researcher at deCODE genetics

Publications -  121
Citations -  22357

Thorgeir E. Thorgeirsson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 49, co-authored 106 publications receiving 18623 citations. Previous affiliations of Thorgeir E. Thorgeirsson include Lawrence Berkeley National Laboratory & University of California, Santa Cruz.

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Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.

Thorgeir E. Thorgeirsson, +106 more
- 01 May 2010 - 
TL;DR: The authors conducted genome-wide association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers and smoking initiation (n = 46,481) using samples from the ENGAGE Consortium.
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Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.

Thorunn Rafnar, +89 more
- 01 Feb 2009 - 
TL;DR: It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other.
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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Douglas M. Ruderfer, +631 more
- 14 Jun 2018 - 
TL;DR: For the first time, specific loci that distinguish between BD and SCZ are discovered and polygenic components underlying multiple symptom dimensions are identified that point to the utility of genetics to inform symptomology and potential treatment.
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A genetic risk factor for periodic limb movements in sleep

Hreinn Stefansson, +25 more
- 16 Aug 2007 - 
TL;DR: The inverse correlation of the variant with iron stores is consistent with the suspected involvement of iron depletion in the pathogenesis of the disease and is associated with susceptibility to periodic limb movements in sleep.
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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.

Florian Zink, +25 more
- 10 Aug 2017 - 
TL;DR: It is found that CH is very common in the elderly, trending toward inevitability, and somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance, however, known CD mutations were evident in only a fraction of CH cases.