Y
Yun Huang
Researcher at Texas A&M University
Publications - 137
Citations - 10404
Yun Huang is an academic researcher from Texas A&M University. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 33, co-authored 124 publications receiving 8762 citations. Previous affiliations of Yun Huang include Texas A&M Health Science Center College of Medicine & Brigham and Women's Hospital.
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Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Journal ArticleDOI
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Myunggon Ko,Yun Huang,Yun Huang,Anna M. Jankowska,Utz Johann Pape,Utz Johann Pape,Mamta Tahiliani,Hozefa S. Bandukwala,Jungeun An,Jungeun An,Edward D. Lamperti,Kian Peng Koh,Rebecca D. Ganetzky,X. Shirley Liu,L. Aravind,Suneet Agarwal,Jaroslaw P. Maciejewski,Anjana Rao,Anjana Rao +18 more
TL;DR: The results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis, which may prove valuable as a diagnostic and prognostic tool to tailor therapies and assess responses to anticancer drugs.
Journal ArticleDOI
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
William A. Pastor,Utz Johann Pape,Utz Johann Pape,Yun Huang,Hope R. Henderson,Hope R. Henderson,Ryan Lister,Myunggon Ko,Erin M. McLoughlin,Yevgeny Brudno,Sahasransu Mahapatra,Philipp Kapranov,Mamta Tahiliani,Mamta Tahiliani,George Q. Daley,X. Shirley Liu,Joseph R. Ecker,Patrice M. Milos,Suneet Agarwal,Anjana Rao,Anjana Rao +20 more
TL;DR: The results indicate that 5hmC has a probable role in transcriptional regulation, and suggest a model in which5hmC contributes to the ‘poised’ chromatin signature found at developmentally-regulated genes in ES cells.
Journal ArticleDOI
Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
Kian Peng Koh,Akiko Yabuuchi,Sridhar Rao,Yun Huang,Kerrianne Cunniff,Julie Nardone,Asta Laiho,Mamta Tahiliani,Cesar Sommer,Gustavo Mostoslavsky,Riitta Lahesmaa,Riitta Lahesmaa,Stuart H. Orkin,Stuart H. Orkin,Stuart H. Orkin,Scott J. Rodig,George Q. Daley,Anjana Rao +17 more
TL;DR: 5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs.
Journal ArticleDOI
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
TL;DR: It is confirmed that the widely used bisulfite sequencing technique does not distinguish between 5-mC and 5-hmC, and it is shown that densely hydroxymethylated regions of DNA may be underrepresented in quantitative methylation analyses.