Institution
Catholic University of the Sacred Heart
Education•Milan, Lombardia, Italy•
About: Catholic University of the Sacred Heart is a education organization based out in Milan, Lombardia, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 13592 authors who have published 31048 publications receiving 853961 citations.
Topics: Population, Medicine, Cancer, Health care, Myocardial infarction
Papers published on a yearly basis
Papers
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University of Rome Tor Vergata1, Dresden University of Technology2, University of Bari3, Catholic University of the Sacred Heart4, University of Hamburg5, Sapienza University of Rome6, Casa Sollievo della Sofferenza7, University of Freiburg8, University of Cagliari9, University of Modena and Reggio Emilia10, Vita-Salute San Raffaele University11, University of Ulm12, Hannover Medical School13
TL;DR: ATRA plus arsenic trioxide is at least not inferior and may be superior to ATRA plus chemotherapy in the treatment of patients with low-to-intermediate-risk APL.
Abstract: Background All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates exceeding 80%. Pilot studies of treatment with arsenic trioxide with or without ATRA have shown high efficacy and reduced hematologic toxicity. Methods
1,184 citations
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TL;DR: A key role for NMS in the clinical frame of PD is supported and the need to address them specifically in clinical trials using dedicated scales is addressed.
Abstract: We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales.
1,151 citations
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Christine G. Elsik1, Christine G. Elsik2, Christine G. Elsik3, Ross L. Tellam3 +325 more•Institutions (65)
TL;DR: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage and provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
1,144 citations
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TL;DR: Evaluating the adequacy of pain management in elderly and minority cancer patients admitted to nursing homes found age, gender, race, marital status, physical function, depression, and cognitive status were independently associated with the presence of pain.
Abstract: Context.—Cancer pain can be relieved with pharmacological agents as indicated
by the World Health Organization (WHO). All too frequently pain management
is reported to be poor.Objective.—To evaluate the adequacy of pain management in elderly and minority
cancer patients admitted to nursing homes.Design.—Retrospective, cross-sectional study.Setting.—A total of 1492 Medicare-certified and/or Medicaid-certified nursing
homes in 5 states participating in the Health Care Financing Administration's
demonstration project, which evaluated the implementation of the Resident
Assessment Instrument and its Minimum Data Set.Study Population.—A group of 13625 cancer patients aged 65 years and older discharged
from the hospital to any of the facilities from 1992 to 1995. Data were from
the multilinked Systematic Assessment of Geriatric Drug Use via Epidemiology
(SAGE) database.Main Outcome Measures.—Prevalence and predictors of daily pain and of analgesic treatment.
Pain assessment was based on patients' report and was completed by a multidisciplinary
team of nursing home personnel that observed, over a 7-day period, whether
each resident complained or showed evidence of pain daily.Results.—A total of 4003 patients (24%, 29%, and 38% of those aged ≥85 years,
75 to 84 years, and 65 to 74 years, respectively) reported daily pain. Age,
gender, race, marital status, physical function, depression, and cognitive
status were all independently associated with the presence of pain. Of patients
with daily pain, 16% received a WHO level 1 drug, 32% a WHO level 2 drug,
and only 26% received morphine. Patients aged 85 years and older were less
likely to receive either weak opiates or morphine than those aged 65 to 74
years (13% vs 38%, respectively). More than a quarter of patients (26%) in
daily pain did not receive any analgesic agent. Patients older than 85 years
in daily pain were also more likely to receive no analgesia (odds ratio [OR],
1.40; 95% confidence interval [CI], 1.13-1.73). Other independent predictors
of failing to receive any analgesic agent were minority race (OR, 1.63; 95%
CI, 1.18-2.26 for African Americans), low cognitive performance (OR, 1.23;
95% CI, 1.05-1.44), and the number of other medications received (OR, 0.65;
95% CI, 0.5-0.84 for 11 or more medications).Conclusions.—Daily pain is prevalent among nursing home residents with cancer and
is often untreated, particularly among older and minority patients.
1,141 citations
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University of Texas MD Anderson Cancer Center1, Princess Margaret Cancer Centre2, Memorial Sloan Kettering Cancer Center3, Hebron University4, European Institute of Oncology5, Ottawa Hospital Research Institute6, University of Manchester7, Catholic University of the Sacred Heart8, French Institute of Health and Medical Research9, Auckland City Hospital10, Royal Brisbane and Women's Hospital11, Ohio State University12, Johns Hopkins University13, University of Washington14, University of California, Los Angeles15, University of Glasgow16, Royal Melbourne Hospital17, Foundation Medicine18, University College London19, Ghent University Hospital20
TL;DR: This trial assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity.
1,139 citations
Authors
Showing all 13795 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peter J. Barnes | 194 | 1530 | 166618 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Dennis R. Burton | 164 | 683 | 90959 |
Paolo Boffetta | 148 | 1455 | 93876 |
Massimo Antonelli | 130 | 1272 | 79319 |
David B. Audretsch | 126 | 671 | 72456 |
Piero Anversa | 115 | 412 | 60220 |
Marco Pahor | 112 | 476 | 46549 |
David L. Paterson | 111 | 739 | 68485 |
Alfonso Caramazza | 108 | 451 | 39280 |
Anthony A. Amato | 105 | 911 | 57881 |
Stefano Pileri | 100 | 635 | 43369 |
Giovanni Gasbarrini | 98 | 894 | 36395 |
Giampaolo Merlini | 96 | 684 | 40324 |
Silvio Donato | 96 | 860 | 41166 |