Institution
Chung-Ang University
Education•Seoul, South Korea•
About: Chung-Ang University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Thin film. The organization has 13381 authors who have published 26978 publications receiving 416735 citations. The organization is also known as: CAU & Chung.
Topics: Population, Thin film, Medicine, Cancer, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: The findings suggest that neighbourhood quality, parental limits and family conflict are significant predictors of children's media use within time or over time, but the significance depends on the type of media and child's developmental stage.
Abstract: The purpose of this paper is to examine the predictors of children's media use in the USA, comparing cross-sectional and longitudinal analyses. Data come from Waves I and 2 of the Child Development Supplement (CDS-I; CDS-II), a nationally representative sample of American children aged 0-12 in 1997 and 5-18 in 2002. Twenty-four hour time use diaries are used to assess children's time spent with media (television, video games, computers, and reading). Predictors examined include socio-demographics, neighbourhood quality, family factors, and other media use. Ordinary least square (OLS) multiple regressions were performed by three age groups (preschoolers, early school age, and preadolescence). The findings suggest that neighbourhood quality, parental limits and family conflict are significant predictors of children's media use within time or over time, but the significance depends on the type of media and child's developmental stage. In addition, children's television viewing and reading habits are formed early in life and reinforced over time. This study is among the first to provide empirical evidence for the effect of early contextual factors on the life course of children's media use from a developmental perspective.
114 citations
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Texas Tech University Health Sciences Center1, University of Manitoba2, Tehran University of Medical Sciences3, University of Bologna4, University of Nebraska Medical Center5, University of Adelaide6, Hong Kong Baptist University7, Chung-Ang University8, Hanyang University9, French Institute of Health and Medical Research10, University of California, Los Angeles11, University of Gothenburg12, National Autonomous University of Mexico13, University of Calgary14
TL;DR: A meta‐analysis of case–control studies that compared immune cell counts in colonic biopsies of IBS patients and controls found that increases in mucosal immune cells have frequently been observed in irritable bowel syndrome patients.
Abstract: Background & Aims
Increases in mucosal immune cells have frequently been observed in irritable bowel syndrome (IBS) patients. However, this finding is not completely consistent between studies, possibly due to a combination of methodological variability, population differences and small sample sizes. We performed a meta-analysis of case–control studies that compared immune cell counts in colonic biopsies of IBS patients and controls.
Methods
PubMed and Embase were searched in February 2017. Results were pooled using standardized mean difference (SMD) and were considered significant when zero was not within the 95% confidence interval (CI). Heterogeneity was assessed based on I2 statistics where I2 ≤ 50% and I2 > 50% indicated fixed and random effect models, respectively.
Key Results
Twenty-two studies on 706 IBS patients and 401 controls were included. Mast cells were increased in the rectosigmoid (SMD: 0.38 [95% CI: 0.06-0.71]; P = .02) and descending colon (SMD: 1.69 [95% CI: 0.65-2.73]; P = .001) of IBS patients. Increased mast cells were observed in both constipation (IBS-C) and diarrhea predominant IBS (IBS-D). CD3+ T cells were increased in the rectosigmoid (SMD: 0.53 [95% CI: 0.21-0.85]; P = .001) and the descending colon of the IBS patients (SMD: 0.79, 95% CI [0.28-1.30]; P = .002). This was possibly in relation to higher CD4+ T cells in IBS (SMD: 0.33 [95% CI: 0.01-0.65]; P = .04) as there were no differences in CD8+ T cells.
Conclusions & Inferences
Mast cells and CD3+ T cells are increased in colonic biopsies of patients with IBS vs non-inflamed controls. These changes are segmental and sometimes IBS-subtype dependent. The diagnostic value of the quantification of colonic mucosal cells in IBS requires further investigation.
114 citations
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TL;DR: Deletion of mir-181a-1/b-1 expression inhibits the development of Notch1 oncogene-induced T cell acute lymphoblastic leukemia (T-ALL) and illustrates that NOTCH oncogen activity in tumor development can be selectively inhibited by targeting the molecular networks controlled by mir- 181a-2b-2 andmir-181-c/d.
Abstract: Oncogenes, which are essential for tumor initiation, development, and maintenance, are valuable targets for cancer therapy. However, it remains a challenge to effectively inhibit oncogene activity by targeting their downstream pathways without causing significant toxicity to normal tissues. Here we show that deletion of mir-181a-1/b-1 expression inhibits the development of Notch1 oncogene-induced T cell acute lymphoblastic leukemia (T-ALL). mir-181a-1/b-1 controls the strength and threshold of Notch activity in tumorigenesis in part by dampening multiple negative feedback regulators downstream of NOTCH and pre-T cell receptor (TCR) signaling pathways. Importantly, although Notch oncogenes utilize normal thymic progenitor cell genetic programs for tumor transformation, comparative analyses of mir-181a-1/b-1 function in normal thymocyte and tumor development demonstrate that mir-181a-1/b-1 can be specifically targeted to inhibit tumor development with little toxicity to normal development. Finally, we demonstrate that mir-181a-1/b-1, but not mir-181a-2b-2 and mir-181-c/d, controls the development of normal thymic T cells and leukemia cells. Together, these results illustrate that NOTCH oncogene activity in tumor development can be selectively inhibited by targeting the molecular networks controlled by mir-181a-1/b-1.
114 citations
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TL;DR: The consumption of adequate nutrients, by taking sufficient amounts and variety of foods, may be important in maintaining adequate cognitive function in elderly Koreans.
113 citations
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TL;DR: It is believed that TRAIL/Dox PLGA MP offer a promise of a sustained-release, long-acting, inhalable anti-lung cancer agent and the synergistic apoptotic effects of the two drugs suggest that the doxorubicin dosage could be substantially reduced and its side effects minimized.
113 citations
Authors
Showing all 13500 results
Name | H-index | Papers | Citations |
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Carl Nathan | 135 | 430 | 91535 |
Scheffer C.G. Tseng | 93 | 333 | 29213 |
Richard L. Sidman | 93 | 297 | 32009 |
H. Yamaguchi | 90 | 375 | 33135 |
Ajith Abraham | 86 | 1113 | 31834 |
Byung Ihn Choi | 78 | 609 | 24925 |
Stefano Soatto | 78 | 499 | 23597 |
J. H. Kim | 73 | 566 | 23052 |
Daehee Kang | 72 | 422 | 23959 |
Lance M. McCracken | 72 | 281 | 18897 |
Masanobu Shinozuka | 69 | 456 | 21961 |
Seung U. Kim | 64 | 355 | 14269 |
Sug Hyung Lee | 64 | 454 | 21552 |
Seung U. Kim | 63 | 129 | 11983 |
Nam Jin Yoo | 63 | 403 | 12692 |