Institution
Curtin University
Education•Perth, Western Australia, Australia•
About: Curtin University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Zircon. The organization has 14257 authors who have published 48997 publications receiving 1336531 citations. The organization is also known as: WAIT & Western Australian Institute of Technology.
Topics: Population, Zircon, Poison control, Context (language use), Health care
Papers published on a yearly basis
Papers
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TL;DR: The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index.
Abstract: Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
517 citations
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Population Health Research Institute1, McMaster University2, Peking Union Medical College3, St. John's University4, University of Cape Town5, University of the Philippines Manila6, Semmelweis University7, University of Amsterdam8, Uppsala University9, UCSI University10, Technion – Israel Institute of Technology11, Charles University in Prague12, National Academy of Sciences of Ukraine13, University of Leicester14, Glenfield Hospital15, Monash University16, Curtin University17, University of Toronto18, University of Caldas19, Laval University20
TL;DR: Therapy with candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a doses of 12.5mg per day was not associated with a lower rate of major cardiovascular events than placebo among persons at intermediate risk who did not have cardiovascular disease.
Abstract: BackgroundAntihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its role in persons at intermediate risk and with lower blood pressure is unclear. MethodsIn one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years. ResultsThe mean blood pressure of the participants at baseline was 138.1/81.9 mm Hg; the decrease in blood pressure was 6.0/3.0 mm Hg greater in the active-treatment group than in the placebo...
512 citations
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TL;DR: In this paper, the authors present a new analysis of the lithospheric architecture of Africa, and its evolution from ca. 3.6 Ga to the present, using thermal/compositional modeling and xenolith/xenocryst data from volcanic rocks.
Abstract: We present a new analysis of the lithospheric architecture of Africa, and its evolution from ca. 3.6 Ga to the present. Upper-lithosphere domains , generated or reworked in different time periods, have been delineated by integrating regional tectonics and geochronology with geophysical data (magnetic, gravity, and seismic). The origins and evolution of lower-lithosphere domains are interpreted from a high-resolution global shear-wave tomographic model, using thermal/compositional modeling and xenolith/xenocryst data from volcanic rocks. These data are integrated to map the distribution of ancient highly depleted subcontinental lithospheric mantle (SCLM), zones of younger or strongly modified SCLM and zones of active mantle upwelling, and to relate these to the evolution of the upper lithosphere domains. The lithospheric architecture of Africa consists of several Archean cratons and smaller cratonic fragments, stitched together and flanked by younger fold belts; the continental assembly as we see it has only existed since lower Paleozoic time. The larger cratons are underlain by geochemically depleted, rigid, and mechanically robust SCLM; these cratonic roots have steep sides, extending in some cases to ≥300-km depth. Beneath smaller cratons (e.g., Kaapvaal) extensive refertilization has reduced the lateral and vertical extent of strongly depleted SCLM. Some cratonic roots extend ≥300 km into the Atlantic Ocean, suggesting that the upper lithosphere may detach during continental breakup, leaving fragments of SCLM scattered in the ocean basin. The cratonic margins, and some intracratonic domain boundaries, have played a major role in the tectonics of Africa. They have repeatedly focused ascending magmas, leading to refertilization and weakening of the SCLM. These boundaries have localized successive cycles of extension, rifting, and renewed accretion; the ongoing development of the East Africa Rift and its branches is only the latest stage in this process. The less depleted SCLM that underlies some accretionary belts may have been generated in Archean time, and repeatedly refertilized by the passage of magmas during younger tectonic events. Our analysis indicates that originally Archean SCLM is far more extensive beneath Africa than previously recognized, and implies that post-Archean SCLM rarely survives the collision/accretion process. Where continental crust and SCLM have remained connected, there is a strong linkage between the tectonic evolution of the crust and the composition and modification of its underlying SCLM.
511 citations
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TL;DR: In this paper, the authors report in situ U-Pb ages and Hf isotopic data on detrital zircons from Paleozoic to Late Mesozoic strata in the Xishan area near Beijing that provide important constraints on the evolution and paleogeography of the northern part of the North China Craton.
511 citations
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TL;DR: In this paper, the authors compare the performance of different interpolation methods for seasonally stable soil properties (pH, electric conductivity and organic matter) that have been demonstrated to affect yield production, and conclude that many parameters would be better identified from the RMSE statistic obtained from cross-validation after an exhaustive testing.
507 citations
Authors
Showing all 14504 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Smith | 129 | 2184 | 100917 |
Christopher G. Maher | 128 | 940 | 73131 |
Mike Wright | 127 | 775 | 64030 |
Shaobin Wang | 126 | 872 | 52463 |
Mietek Jaroniec | 123 | 571 | 79561 |
John B. Holcomb | 120 | 733 | 53760 |
Simon A. Wilde | 118 | 390 | 45547 |
Jian Liu | 117 | 2090 | 73156 |
Meilin Liu | 117 | 827 | 52603 |
Guochun Zhao | 113 | 406 | 40886 |
Mark W. Chase | 111 | 519 | 50783 |
Robert U. Newton | 109 | 753 | 42527 |
Simon P. Driver | 109 | 455 | 46299 |
Peter R. Schofield | 109 | 693 | 50892 |
Gao Qing Lu | 108 | 546 | 53914 |