Institution
Curtin University
Education•Perth, Western Australia, Australia•
About: Curtin University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Zircon. The organization has 14257 authors who have published 48997 publications receiving 1336531 citations. The organization is also known as: WAIT & Western Australian Institute of Technology.
Topics: Population, Zircon, Poison control, Context (language use), Health care
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a longitudinal study of autonomous work groups at a new and an established minerals processing plant was conducted and the results of the study support the proposition that employees in auto-professionals are more likely to participate in autonomous work.
Abstract: This article reports on a longitudinal study of autonomous work groups at a new and an established minerals processing plant. The results of the study support the proposition that employees in auto...
284 citations
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University of Washington1, Desert Research Institute2, Oregon State University3, University of Colorado Boulder4, Pennsylvania State University5, Xi'an Jiaotong University6, University of Minnesota7, United States Geological Survey8, South Dakota State University9, University of California, Berkeley10, Curtin University11, University of Wisconsin-Madison12, Victoria University of Wellington13, University of California, San Diego14, University of Copenhagen15, Lake Superior State University16, Nanyang Technological University17, Dartmouth College18
TL;DR: Results from a new, annually resolved ice-core record from West Antarctica suggest a more active role for the Southern Ocean in the onset of deglaciation than is inferred from ice cores in the East Antarctic interior, which are largely isolated from sea-ice changes.
Abstract: An annually resolved ice-core record from West Antarctica indicates that warming driven by local insolation resulting from sea-ice decline began in that region about 2,000 years before warming in East Antarctica, reconciling two alternative explanations for deglacial warming in the Southern Hemisphere.
284 citations
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Population Health Research Institute1, McMaster University2, St. John's University3, Peking Union Medical College4, Universidad del Norte, Colombia5, National Academy of Sciences of Ukraine6, Semmelweis University7, University of Cape Town8, University of Amsterdam9, Uppsala University10, UCSI University11, Technion – Israel Institute of Technology12, University of Leicester13, Glenfield Hospital14, Monash University15, Curtin University16, University of Toronto17, Charles University in Prague18, University of the Philippines Manila19, Laval University20
TL;DR: The combination of rosuvastatin, candesartan, and hydrochlorothiazide was associated with a significantly lower rate of cardiovascular events than dual placebo among persons at intermediate risk who did not have cardiovascular disease.
Abstract: BACKGROUND Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially.METHODS In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12.5 mg per day) or placebo. In the analyses reported here, we compared the 3180 participants assigned to combined therapy (with rosuvastatin and the two antihypertensive agents) with the 3168 participants assigned to dual placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included heart failure, cardiac arrest, or revascularization. The median follow-up was 5.6 years.RESULTS The decrease in the LDL cholesterol level was 33.7 mg per deciliter (0.87 mmol per liter) greater in the combined-therapy group than in the dual-placebo group, and the decrease in systolic blood pressure was 6.2 mm Hg greater with combined therapy than with dual placebo. The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], 0.56 to 0.90; P=0.005). The second coprimary outcome occurred in 136 participants (4.3%) and 187 participants (5.9%), respectively (hazard ratio, 0.72; 95% CI, 0.57 to 0.89; P=0.003). Muscle weakness and dizziness were more common in the combined-therapy group than in the dual-placebo group, but the overall rate of discontinuation of the trial regimen was similar in the two groups.CONCLUSIONS The combination of rosuvastatin (10 mg per day), candesartan (16 mg per day), and hydrochlorothiazide (12.5 mg per day) was associated with a significantly lower rate of cardiovascular events than dual placebo among persons at intermediate risk who did not have cardiovascular disease. (ClinicalTrials.gov number, NCT00468923.)
283 citations
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University of Copenhagen1, Technical University of Denmark2, American Museum of Natural History3, University of Greenland4, Spanish National Research Council5, Royal Belgian Institute of Natural Sciences6, University of Tübingen7, North-Eastern Federal University8, Catalan Institution for Research and Advanced Studies9, Norwegian University of Science and Technology10, Curtin University11
TL;DR: The observations suggest that the BGISEQ-500 holds the potential to represent a valid and potentially valuable alternative platform for palaeogenomic data generation that is worthy of future exploration by those interested in the sequencing and analysis of degraded DNA.
Abstract: Ancient DNA research has been revolutionized following development of next-generation sequencing platforms. Although a number of such platforms have been applied to ancient DNA samples, the Illumina series are the dominant choice today, mainly because of high production capacities and short read production. Recently a potentially attractive alternative platform for palaeogenomic data generation has been developed, the BGISEQ-500, whose sequence output are comparable with the Illumina series. In this study, we modified the standard BGISEQ-500 library preparation specifically for use on degraded DNA, then directly compared the sequencing performance and data quality of the BGISEQ-500 to the Illumina HiSeq2500 platform on DNA extracted from 8 historic and ancient dog and wolf samples. The data generated were largely comparable between sequencing platforms, with no statistically significant difference observed for parameters including level (P = 0.371) and average sequence length (P = 0718) of endogenous nuclear DNA, sequence GC content (P = 0.311), double-stranded DNA damage rate (v. 0.309), and sequence clonality (P = 0.093). Small significant differences were found in single-strand DNA damage rate (δS; slightly lower for the BGISEQ-500, P = 0.011) and the background rate of difference from the reference genome (θ; slightly higher for BGISEQ-500, P = 0.012). This may result from the differences in amplification cycles used to polymerase chain reaction-amplify the libraries. A significant difference was also observed in the mitochondrial DNA percentages recovered (P = 0.018), although we believe this is likely a stochastic effect relating to the extremely low levels of mitochondria that were sequenced from 3 of the samples with overall very low levels of endogenous DNA. Although we acknowledge that our analyses were limited to animal material, our observations suggest that the BGISEQ-500 holds the potential to represent a valid and potentially valuable alternative platform for palaeogenomic data generation that is worthy of future exploration by those interested in the sequencing and analysis of degraded DNA.
282 citations
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TL;DR: To investigate the relationship between a child's weight and a broad range of family and maternal factors, a large number of children from low-income families are surveyed.
Abstract: to support the hypothesis that obese children come from families displaying such dysfunctional traits. 5,6 Thus, no clear pattern of family dynamics has consistently been associated with obesity. Previous studies examining the role of family and parental factors in childhood obesity have often been limited by small sample sizes, and a single measure of family function/dysfunction. Moreover, most previous studies have been based on the assumption that poor family functioning will be associated with inadequate parental monitoring and/or regulation of children’s eating and activity patterns. However, no specific underlying theory or mechanisms have been hypothesised to explain any role of family factors in childhood obesity. The role of the family has implications for the treatment of obese children — familybased treatment programs for obese children are based on the theory that parenting style, family functioning, and the home environment are key factors. 7-9 There is evidence of the long-term effectiveness of this approach. 7 We aimed to examine the relationship between a child’s weight and a broad range of family and maternal factors. Our hypothesis was that increasing adiposity in children would be associated with poor general family functioning (eg, poor communication, inadequate support towards other family members, poor problem-solving skills), lower socioeconomic status, inappropriate parenting style (eg, too lax or too controlling), the experience of negative life events in the family, and maternal psychopathology.
282 citations
Authors
Showing all 14504 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Smith | 129 | 2184 | 100917 |
Christopher G. Maher | 128 | 940 | 73131 |
Mike Wright | 127 | 775 | 64030 |
Shaobin Wang | 126 | 872 | 52463 |
Mietek Jaroniec | 123 | 571 | 79561 |
John B. Holcomb | 120 | 733 | 53760 |
Simon A. Wilde | 118 | 390 | 45547 |
Jian Liu | 117 | 2090 | 73156 |
Meilin Liu | 117 | 827 | 52603 |
Guochun Zhao | 113 | 406 | 40886 |
Mark W. Chase | 111 | 519 | 50783 |
Robert U. Newton | 109 | 753 | 42527 |
Simon P. Driver | 109 | 455 | 46299 |
Peter R. Schofield | 109 | 693 | 50892 |
Gao Qing Lu | 108 | 546 | 53914 |