Danube University Krems

About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.

Standards of practice in acute ischemic stroke intervention: International recommendations

Abstract: After the five positive randomized controlled trials showing the benefit of mechanical thrombectomy (MT) in the management of acute ischemic stroke (AIS) with emergent large vessel occlusion (ELVO), a multisociety meeting was organized during the 16th Congress of the World Federation of

Preparation and characterization of cellulose microspheres

Abstract: The aim of this work was to synthesize and characterize cellulose microspheres with a particle size below 5 μm and narrow size distribution. After activation and functionalization with antibodies, these particles shall be applied as adsorbents in suspension-based extracorporeal blood purification systems, such as the Microspheres-Based Detoxification System. In the frame of this work such microspheres were developed and synthesized with reproducible properties. Besides using well-established methods for characterization of this kind of bead cellulose, additional procedures for the examination of its properties were developed and applied.

Treatment of central nervous system manifestations in mitochondrial disorders

Abstract: Central nervous system (CNS) manifestations of mitochondrial disorders (MIDs) are accessible to therapy. Therapy of CNS abnormalities may be categorized as acting on the pathogenic cascade or on the genetic level, which is experimental. Treatment acting on the pathogenic cascade may be classified as non-specific, including antioxidants, electron donors/acceptors, lactate-lowering agents, alternative energy providers, cofactors, avoidance of mitochondrion-toxic drugs, and physiotherapy, or as specific, including drugs against epilepsy, movement disorders, migraine, spasticity, psychiatric abnormalities, hypopituitarism, or bulbar manifestations, ketogenic diet, deep brain stimulation, or artificial ventilation. Stroke-like episodes need to be delineated from ischaemic stroke and require special management. Potentially, mitochondrion-toxic drugs and drug cocktails need to be avoided, seizures should be consequently treated even with mitochondrion-toxic drugs if necessary, and as few drugs as possible should be given. Effective treatment acting on the pathogenic cascade may increase the quality of life and outcome in patients with MID and may prevent a therapeutic nihilism occasionally upcoming with MIDs.

Effective Removal of Estrogens from Drinking Water and Wastewater by Adsorption Technology

Abstract: Estrogens, either of natural or synthetic origin, are well known for their impact on the reproductive system of both humans and animals. With conventional wastewater treatment it is not possible to remove estrogens efficiently. Subsequently, estrogen contaminated water enters the hydrological cycle and leads to an accumulation in surface water, groundwater as well as in drinking water. Therefore, new methods have to be introduced in order to face the increasing contamination of wastewater. Aim of this in vitro study was the characterization of adsorbents which are used in the field of extracorporeal blood purification for their potential use in wastewater treatment. For the conducted batch experiments, we used activated carbon as well as hydrophobic resins and anion exchangers to characterize their adsorption kinetics and capacity for estrogen. 17β-Estradiol (E2), as a model substance for the natural estrogens (E1–E4), as well as synthetic 17α-ethinylestradiol (EE2) were added to both distilled water and water taken from the draining channel of a local purification plant. Adsorbents were added at a concentration of 1 g/L water. Samples were taken at 0, 15, 30, 60 and 120 min and analyzed by a newly developed simplified HPLC-based method. Our results show that hydrophobic resins based on Polystyrene-Divinylbenzene (PS-DVB) are promising materials for the effective removal of estrogens from wastewater. Adsorption technology could be an efficient technique to upgrade sewage treatment plants for the removal of estrogens from the hydrological cycle.