Danube University Krems

About: Danube University Krems is a education organization based out in Krems, Niederösterreich, Austria. It is known for research contribution in the topics: Stroke & Population. The organization has 498 authors who have published 1572 publications receiving 68797 citations.

Gold Nanowires/Fibrin Nanostructure as Microfluidics Platforms for Enhancing Stem Cell Differentiation: Bio-AFM Study.

Abstract: Organ-on-a-chip technology has gained great interest in recent years given its ability to control the spatio-temporal microenvironments of cells and tissues precisely. While physical parameters of the respective niche such as microchannel network sizes, geometric features, flow rates, and shear forces, as well as oxygen tension and concentration gradients, have been optimized for stem cell cultures, little has been done to improve cell-matrix interactions in microphysiological systems. Specifically, detailed research on the effect of matrix elasticity and extracellular matrix (ECM) nanotopography on stem cell differentiation are still in its infancy, an aspect that is known to alter a stem cell's fate. Although a wide range of hydrogels such as gelatin, collagen, fibrin, and others are available for stem cell chip cultivations, only a limited number of elasticities are generally employed. Matrix elasticity and the corresponding nanotopography are key factors that guide stem cell differentiation. Given this, we investigated the addition of gold nanowires into hydrogels to create a tunable biointerface that could be readily integrated into any organ-on-a-chip and cell chip system. In the presented work, we investigated the matrix elasticity (Young's modulus, stiffness, adhesive force, and roughness) and nanotopography of gold nanowire loaded onto fibrin hydrogels using the bio-AFM (atomic force microscopy) method. Additionally, we investigated the capacity of human amniotic mesenchymal stem cells (hAMSCs) to differentiate into osteo- and chondrogenic lineages. Our results demonstrated that nanogold structured-hydrogels promoted differentiation of hAMSCs as shown by a significant increase in Collagen I and II production. Additionally, there was enhanced calcium mineralization activity and proteoglycans formation after a cultivation period of two weeks within microfluidic devices.

Thermal activation in permanent magnets

Abstract: The coercive field of permanent magnets decays with temperature. At non-zero temperature the system can overcome a finite energy barrier through thermal fluctuations. Using finite element micromagnetic simulations, we quantify this effect, which reduces coercivity in addition to the decrease of the coercive field associated with the temperature dependence of the anisotropy field, and validate the method through comparison with existing experimental data.

Teachers responding to cultural diversity: case studies on assessment practices, challenges and experiences in secondary schools in Austria, Ireland, Norway and Turkey

Abstract: Global mobility and economic and political crises in some parts of the world have fuelled migration and brought new constellations of ‘cultural diversity’ to European classrooms (OECD 2019). This produces new challenges for teaching, but also for assessment in which cultural biases may have far-reaching consequences for the students’ further careers in education, occupation and life. After considering the concept of and current research on ‘culturally responsive assessment’, we use qualitative interview data from 115 teachers and school leaders in 20 lower secondary schools in Austria, Ireland, Norway and Turkey to explore the thinking about diversity and assessment practices of teachers in the light of increasing cultural diversity. Findings suggest that ‘proficiency in the language of instruction’ is the main dimension by which diversity in classrooms is perceived. While there is much less reference to ‘cultural differences’ in our case studies, we found many teachers in case schools trying to adapt their assessment procedures and grading in order to help students from diverse backgrounds to show their competencies and to experience success. However, these responses were, in many cases, individualistic rather than organised by the school or regional education authorities and were also strongly influenced and at times, limited by government-mandated assessment regimes that exist in each country. The paper closes with a series of recommendations to support the further development of a practicable and just practice of culturally responsive assessment in schools.

On the limits of coercivity in permanent magnets

Abstract: The maximum coercivity that can be achieved for a given hard magnetic alloy is estimated by computing the energy barrier for the nucleation of a reversed domain in an idealized microstructure without any structural defects and without any soft magnetic secondary phases. For Sm$_{1-z}$Zr$_z$(Fe$_{1-y}$Co$_y$)$_{12-x}$Ti$_x$ based alloys, which are considered an alternative to Nd$_2$Fe$_{14}$B magnets with lower rare-earth content, the coercive field of a small magnetic cube is reduced to 60 percent of the anisotropy field at room temperature and to 50 percent of the anisotropy field at elevated temperature (473K). This decrease of the coercive field is caused by misorientation, demagnetizing fields and thermal fluctuations.

When digital government matters for tourism: a stakeholder analysis

Abstract: Despite the importance of governance processes for destination management and the impact of digital technology on such processes, surprisingly little academic research has explored the use of digital technology to transform public governance in the tourism sector. This conceptual paper fills this gap by conducting a digital government stakeholder analysis for the tourism sector using the digital government evolution model as its theoretical foundation. The analysis identifies six relevant stakeholder groups: governments, businesses, non-profits, citizens, visitors and employees. It examines six types of technology-enabled interactions between government and other stakeholders: government-to-government, government-to-business, government-to-non-profit, government-to-citizen, government-to-visitor and government-to-employee. These interactions are illustrated with real-life examples. The analysis contributes to identifying pressures on tourism authorities and determining how the authorities respond to such pressures, how they innovate their operations and policies with digital technologies, and how these innovations are institutionalized over time. The results contribute to building the theoretical foundations for sector-specific digital government and enable strategic discussion on the use of commercially viable and socially responsible digital innovation to advance the tourism sector.