Institution
Indian Institute of Technology Guwahati
Education•Guwahati, Assam, India•
About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.
Papers published on a yearly basis
Papers
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TL;DR: Wavelet Energy based diagnostic distortion (WEDD) provides a better prediction accuracy and exhibits a statistically better monotonic relationship with the MOS ratings than Wavelet based weighted percentage root mean square difference (PRD) measure (WWPRD), PRD and other objective measures.
135 citations
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TL;DR: In this paper, a low temperature solvothermal growth of few layer MoS2 nanoflowers (NFs) over the porous TiO2(B) nanobelts (NBs) for enhanced hydrogen evolution reaction (HER) in acidic media as well as improved photocatalytic degradation of organic dye rhodamine-B (RhB) under visible light.
135 citations
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TL;DR: It can be concluded that the appropriate proportion of cattle manure addition (Trial 4) significantly reduced the mobile and easily available fractions (exchangeable and carbonate fractions) during the composting process.
134 citations
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TL;DR: In this paper, the authors used COSMO-RS to predict the capacity and selectivity of anion-based IL's for 15 reported ternary systems containing thiophene as one of the sulphur derivative.
134 citations
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TL;DR: These methods include minimization or elimination of viral genes, retargeting of vector to the tissue of interest, and generation of immunocompromised recombinant vectors that lead to safer use of Ad vector systems that improve persistence of transgene expression.
Abstract: Gene therapy is a promising tool for treatment of the human diseases that cannot be cured by rational therapies, and its primary success depends on suitable vectors to deliver therapeutic genes. Adenoviruses (Ads) are among the most commonly used vectors for gene therapy, second only to retroviruses. During the last decade, remarkable progress has been made in the development of Ad vectors and in the understanding of the toxicity related to the Ad vector system. Ad vector has certain advantages such as high transduction efficiency for different quiescent and dividing cell types and high levels of short-term expression to provide therapeutic benefits. However, researchers are facing the challenges associated with tissue-specific targeting of vectors and the vector-mediated immunogenicity. This review mainly focuses on the studies that have employed methods to improve Ad vectors and reduce viral toxicity for different applications. These methods include minimization or elimination of viral genes, retargeting of vector to the tissue of interest, and generation of immunocompromised recombinant vectors that lead to safer use of Ad vector systems that improve persistence of transgene expression. Moreover, the therapeutic applications of Ad vectors for liver-targeted gene therapy, suicide gene therapy, delivery of small interfering RNA, and production of recombinant vaccine under regulated conditions used in clinical trials are discussed.
134 citations
Authors
Showing all 7128 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jasvinder A. Singh | 176 | 2382 | 223370 |
Dipanwita Dutta | 143 | 1651 | 103866 |
Sanjay Gupta | 99 | 902 | 35039 |
Santosh Kumar | 80 | 1196 | 29391 |
Subrata Ghosh | 78 | 841 | 32147 |
Rishi Raj | 78 | 569 | 22423 |
B. Bhuyan | 73 | 658 | 21275 |
Ravi Shankar | 66 | 672 | 19326 |
Ashutosh Sharma | 66 | 570 | 16100 |
Gautam Biswas | 63 | 721 | 16146 |
Sam P. de Visser | 62 | 256 | 13820 |
Surendra Nadh Somala | 61 | 144 | 28273 |
Manish Kumar | 61 | 1425 | 21762 |
Mihir Kumar Purkait | 57 | 267 | 9812 |
Ajaikumar B. Kunnumakkara | 57 | 201 | 20025 |