Indian Institute of Technology Guwahati

About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.

Adaptive second order terminal sliding mode controller for robotic manipulators

Abstract: In this paper an adaptive second order terminal sliding mode (SOTSM) controller is proposed for controlling robotic manipulators. Instead of the normal control input, its time derivative is used in the proposed controller. The discontinuous sign function is contained in the derivative control and the actual control obtained after integration is continuous and hence chatterless. An adaptive tuning method is utilized to deal with the system uncertainties whose upper bounds are not required to be known in advance. The performance of the proposed control strategy is evaluated through the control of a two-link rigid robotic manipulator. Simulation results demonstrate the effectiveness of the proposed control method.

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

Abstract: Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical structure of curcumin as diferuloylmethane was reported by Milobedzka et al. [(1910) 43., 2163-2170]. Since then, this polyphenol has been shown to exhibit antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antifungal activities. The current review primarily focuses on the anticancer potential of curcumin through the modulation of multiple cell signaling pathways. Curcumin modulates diverse transcription factors, inflammatory cytokines, enzymes, kinases, growth factors, receptors, and various other proteins with an affinity ranging from the pM to the mM range. Furthermore, curcumin effectively regulates tumor cell growth via modulation of numerous cell signaling pathways and potentiates the effect of chemotherapeutic agents and radiation against cancer. Curcumin can interact with most of the targets that are modulated by FDA-approved drugs for cancer therapy. The focus of this review is to discuss the molecular basis for the anticancer activities of curcumin based on preclinical and clinical findings.

Evaluating effects of traffic and vehicle characteristics on vehicular emissions near traffic intersections

Abstract: Urban air quality is generally poor at traffic intersections due to variations in vehicles’ speeds as they approach and leave This paper examines the effect of traffic, vehicle and road characteristics on vehicular emissions with a view to understand a link between emissions and the most likely influencing and measurable characteristics It demonstrates the relationships of traffic, vehicle and intersection characteristics with vehicular exhaust emissions and reviews the traffic flow and emission models Most studies have found that vehicular exhaust emissions near traffic intersections are largely dependent on fleet speed, deceleration speed, queuing time in idle mode with a red signal time, acceleration speed, queue length, traffic-flow rate and ambient conditions The vehicular composition also affects emissions These parameters can be quantified and incorporated into the emission models There is no validated methodology to quantify some non-measurable parameters such as driving behaviour, pedestrian activity, and road conditions