Indian Institute of Technology Guwahati

About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.

Artificial neural network model for synthetic streamflow generation

Abstract: Time series of streamflow plays an important role in planning, design and management of water resources system. In the event of non availability of a long series of historical streamflow record, generation of the data series is of utmost importance. Although a number of models exist, they may not always produce satisfactory result in respect of statistics of the historical data. In such event, artificial neural network (ANN) model can be a potential alternative to the conventional models. Streamflow series, which is a stochastic phenomenon, can be suitably modeled by ANN for its strong capability to perform non-linear mapping. An ANN model developed for generating synthetic streamflow series of the Pagladia River, a major north bank tributary of the river Brahmaputra, is presented in this paper along with its comparison with other existing models. The comparison carried out in respect of five different statistics of the historical data and synthetically generated data has shown that among the different models, viz., autoregressive moving average (ARMA) model, Thomas-Fiering model and ANN model, the ANN based model has performed better in generating synthetic streamflow series for the Pagladia River.

Functionalized PVA-silk blended nanofibrous mats promote diabetic wound healing via regulation of extracellular matrix and tissue remodelling.

Abstract: Chronic cutaneous ulcers, a complex pathophysiological diabetic condition, represent a critical clinical challenge in the current diabetes mellitus pandemic. Consequently, there is a compelling need for bioactive dressings that can trigger healing processes for complete wound repair. Silk fibroin (SF), a natural protein polymer from mulberry and non-mulberry silkworms, has properties that support accelerated wound healing rate. SF from non-mulberry variety possesses additional cell-binding motifs (arginine, glycine, and aspartate), offering cell-material interactions. This study is aimed to investigate wound healing efficacy of dressings made up of various SF varieties blended with poly(vinyl alcohol) biopolymer in alloxan-induced diabetic rabbit model. The nanofibrous mats have been developed using electrospinning and functionalized with growth factors and LL-37 antimicrobial peptide for sustained delivery. Following post 14-day treatment, non-mulberry SF (NMSF)-based dressings healed the wounds faster, in comparison with their mulberry Bombyx mori SF, poly(vinyl alcohol), and control counterparts (p < .01). NMSF-based dressings also supported faster granulation tissue development, angiogenesis, and reepithelialization of wounds. Gene expression study of matrix metalloproteinases and collagen proteins affirmed higher extent of tissue remodelling during the repair process. Furthermore, there was organized extracellular matrix deposition (collagen type I, collagen type III, elastin, and reticulin) and higher wound breaking strength in NMSF compared with other groups after 4 weeks. These results validated the potential of NMSF-based bioactive dressings to regulate extracellular matrix deposition leading to faster and complete repair of chronic diabetic cutaneous wounds.

Observation of Zb(10610) and Zb(10650) Decaying to B Mesons

Abstract: We report the analysis of the three-body e(+)e(-) -> B (B) over bar pi(+/-), B (B) over bar*pi(+/-), and B*(B) over bar* pi(+/-) processes, including the first observations of the Z(b)(+/-)(10610) -> [B (B) over bar* + c.c.](+/-) and Z(b)(+/-)(10650) -> [B*(B) over bar*](+/-) transitions that are found to dominate the corresponding final states. We measure Born cross sections for the three-body production of sigma(e(+)e(-) -> [B (B) over bar* + c.c.](+/-)pi(-/+)) = [17.4 +/- 1.6(stat) +/- 1.9(syst)]pb and sigma(e(+)e(-) -> [B*(B) over bar*](+/-)pi(-/+)) = [8.75 +/- 1.15(stat) +/- 1.04(syst)] pb and set a 90% C.L. upper limit of sigma(e(+)e(-) -> [B (B) over bar](+/-)pi(-/+)) < 2.9 pb. The results are based on a 121.4 fb(-1) data sample collected with the Belle detector at a center-of-mass energy near the Upsilon(10860) peak.

Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations.

Abstract: Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, which are also equally potent as curcuminoids. This review aims to explore the comprehensive potency including the identification, physicochemical properties, and anticancer mechanism inclusive of molecular docking studies of non-curcuminoids such as turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin. An insight into the clinical studies of these curcumin-free compounds are also discussed which provides ample evidence that favors the therapeutic potential of these compounds. Like curcuminoids, limited solubility and bioavailability are the most fragile domain, which circumscribe further applications of these compounds. Thus, this review credits the encapsulation of non-curcuminoid components in diverse drug delivery systems such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, polar-non-polar sandwich (PNS) technology, which help abolish their shortcomings and flaunt their ostentatious benefits as anticancer activities.