Institution
Kadi Sarva Vishwavidyalaya
Education•Gandhinagar, Gujarat, India•
About: Kadi Sarva Vishwavidyalaya is a education organization based out in Gandhinagar, Gujarat, India. It is known for research contribution in the topics: Matrix (chemical analysis) & Mass spectrometry. The organization has 131 authors who have published 158 publications receiving 1343 citations.
Topics: Matrix (chemical analysis), Mass spectrometry, Triple quadrupole mass spectrometer, Ion suppression in liquid chromatography–mass spectrometry, High-performance liquid chromatography
Papers
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TL;DR: In this paper, a new piprazole analogue drug, brexpiprazole (BREX), with coformers such as succinic acid and catechol was carried out using ball milling to address the poor solubility and dissolution rate of the molecule.
Abstract: In the present study, cocrystallization of a new piprazole analogue drug, brexpiprazole (BREX), with coformers such as succinic acid and catechol was carried out using ball milling to address the poor solubility and dissolution rate of the molecule. Before initiating cocrystallization, several ball milling process parameters, including milling time, ball size and RPM were optimized to obtain the cocrystals with the highest purity and yield. The cocrystals generated using the optimized ball milling process were characterized using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), hot stage microscopy, Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. Equilibrium solubility and dissolution studies on the cocrystals were performed in 0.05 M acetate buffer, pH 4.3. Nearly 2.5 fold enhancements in the equilibrium solubility and dissolution rate have been observed with the cocrystals compared to plain BREX and its physical mixture with the coformers.
17 citations
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TL;DR: A simple, reliable and reproducible liquid chromatography–tandem mass spectrometry method for the simultaneous determination of allopurinol and its active metabolite, oxypur inol in human plasma for a pharmacokinetic/bioequivalence study.
16 citations
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TL;DR: A simple, precise and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oselTAMivir carboxylate, a neuraminidase inhibitor, using their deuterated analogs as internal standards (ISs).
16 citations
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TL;DR: The current article represents a review of epigenetic heritance, diseases connected with epigenetic alterations and regulatory approved epigenetic drugs as future medicines.
Abstract: All the heritable alterations in gene expression and chromatin structure due to chemical modifications that do not involve changes in the primary gene nucleotide sequence are referred to as epigenetics. DNA methylation, histone modifications, and non-coding RNAs are distinct types of epigenetic inheritance. Epigenetic patterns have been linked to the developmental stages, environmental exposure, and diet. Therapeutic strategies are now being developed to target human diseases such as cancer with mutations in epigenetic regulatory genes using specific inhibitors. Within the past two decades, seven epigenetic drugs have received regulatory approval and many others show their candidature in clinical trials. The current article represents a review of epigenetic heritance, diseases connected with epigenetic alterations and regulatory approved epigenetic drugs as future medicines.
16 citations
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TL;DR: An improved high performance liquid chromatography--tandem mass spectrometry (LC–MS/MS) method has been developed for sensitive and rapid determination of albendazole (ABZ) and its active metabolite, albENDazole sulfoxide ( ABZSO), in the positive ionization mode and was successfully applied for two separate studies in healthy subjects.
15 citations
Authors
Showing all 133 results
Name | H-index | Papers | Citations |
---|---|---|---|
Sunita Varjani | 31 | 211 | 4086 |
Pranav S. Shrivastav | 28 | 205 | 3287 |
Mallika Sanyal | 21 | 110 | 1296 |
Gaurang B. Shah | 18 | 67 | 971 |
Hetal Patel | 18 | 93 | 1377 |
Pragna K. Shelat | 13 | 51 | 543 |
Puran Singhal | 13 | 37 | 417 |
Bhavesh S. Barot | 11 | 24 | 405 |
Punit B. Parejiya | 11 | 29 | 429 |
Hiren Patel | 10 | 49 | 1010 |
Rakesh Kumar Ameta | 9 | 25 | 278 |
Amit B. Patel | 8 | 18 | 144 |
Anita Lalwani | 8 | 16 | 192 |
Shivam Kansara | 8 | 26 | 195 |
Ritesh Patel | 7 | 29 | 123 |