McGill University

About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.

Renal and Retinal Effects of Enalapril and Losartan in Type 1 Diabetes

Abstract: Background Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin–angiotensin system. Methods We conducted a multicenter, controlled trial involving 285 normotensive patients with type 1 diabetes and normoalbuminuria and who were randomly assigned to receive losartan (100 mg daily), enalapril (20 mg daily), or placebo and followed for 5 years. The primary end point was a change in the fraction of glomerular volume occupied by mesangium in kidney-biopsy specimens. The retinopathy end point was a progression on a retinopathy severity scale of two steps or more. Intention-to-treat analysis was performed with the use of linear regression and logistic-regression models. Results A total of 90% and 82% of patients had complete renal-biopsy and retinopathy data, respectively. Change in mesangial fractional volume per glomerulus over the 5-year period did not differ significantly between the placebo group (0.016 units) and the enalapril group (0.005, P = 0.38) or the losartan group (0.026, P = 0.26), nor were there significant treatment benefits for other biopsy-assessed renal structural variables. The 5-year cumulative incidence of microalbuminuria was 6% in the placebo group; the incidence was higher with losartan (17%, P = 0.01 by the log-rank test) but not with enalapril (4%, P = 0.96 by the log-rank test). As compared with placebo, the odds of retinopathy progression by two steps or more was reduced by 65% with enalapril (odds ratio, 0.35; 95% confidence interval [CI], 0.14 to 0.85) and by 70% with losartan (odds ratio, 0.30; 95% CI, 0.12 to 0.73), independently of changes in blood pressure. There were three biopsy-related serious adverse events that completely resolved. Chronic cough occurred in 12 patients receiving enalapril, 6 receiving losartan, and 4 receiving placebo. Conclusions Early blockade of the renin–angiotensin system in patients with type 1 diabetes did not slow nephropathy progression but slowed the progression of retinopathy. (ClinicalTrials.gov number, NCT00143949.)

Small particles, big impacts: A review of the diverse applications of nanofluids

Abstract: Nanofluids—a simple product of the emerging world of nanotechnology—are suspensions of nanoparticles (nominally 1–100 nm in size) in conventional base fluids such as water, oils, or glycols. Nanofluids have seen enormous growth in popularity since they were proposed by Choi in 1995. In the year 2011 alone, there were nearly 700 research articles where the term nanofluid was used in the title, showing rapid growth from 2006 (175) and 2001 (10). The first decade of nanofluid research was primarily focused on measuring and modeling fundamental thermophysical properties of nanofluids (thermal conductivity, density, viscosity, heat transfer coefficient). Recent research, however, explores the performance of nanofluids in a wide variety of other applications. Analyzing the available body of research to date, this article presents recent trends and future possibilities for nanofluids research and suggests which applications will see the most significant improvement from employing nanofluids.

How do traits vary across ecological scales? A case for trait‐based ecology

Abstract: Despite the increasing importance of functional traits for the study of plant ecology, we do not know how variation in a given trait changes across ecological scales, which prevents us from assessing potential scale-dependent aspects of trait variation. To address this deficiency, we partitioned the variance in two key functional traits (leaf mass area and leaf dry matter content) across six nested ecological scales (site, plot, species, tree, strata and leaf) in lowland tropical rainforests. In both traits, the plot level shows virtually no variance despite high species turnover among plots and the size of withinspecies variation (leaf + strata + tree) is comparable with that of species level variation. The lack of variance at the plot level brings substantial support to the idea that traitbased environmental filtering plays a central role in plant community assembly. These results and the finding that the amount of within-species variation is comparable with interspecific variation support a shift of focus from species-based to trait-based ecology.

Discourse and Deinstitutionalization: the Decline of DDT

Abstract: Drawing on institutional theory emphasizing translation and discourse, we explore outsider-driven deinstitutionalization through a case study of the abandonment of widespread, taken-for-granted practices of DDT use between 1962 and 1972. Our findings illustrate how abandonment of practices results from “problematizations” that—through subsequent “translation”—change discourse in ways that undermine the institutional pillars supporting practices. This occurs through new “subject positions” from which actors speak and act in support of problematizations, and new bodies of knowledge, which normalize them. We introduce the concept of “defensive institutional work” and illustrate how actors carry out disruptive and defensive work by authoring texts.