Institution
McGill University
Education•Montreal, Quebec, Canada•
About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.
Topics: Population, Context (language use), Poison control, Health care, Cancer
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Failure to fully evaluate the assumptions underlying these hypotheses may have led to erroneous generalizations regarding the importance of size at age/stage and growth rate on the probability of death due to predation, and neither the ‘bigger is better’, nor the ’stage duration’ hypotheses is unequivocally supported.
732 citations
••
TL;DR: A brief overview of some of the new methods in NMR spectroscopy, together with applications that illustrate the level of detail at which protein motions can now be observed, are presented.
Abstract: There is growing evidence that structural flexibility plays a central role in the function of protein molecules. Many of the experimental data come from nuclear magnetic resonance (NMR) spectroscopy, a technique that allows internal motions to be probed with exquisite time and spatial resolution. Recent methodological advancements in NMR have extended our ability to characterize protein dynamics and promise to shed new light on the mechanisms by which these molecules function. Here, we present a brief overview of some of the new methods, together with applications that illustrate the level of detail at which protein motions can now be observed.
732 citations
••
TL;DR: The potential underlying mechanisms involved in the regulation of the mitochondrial checkpoint are reviewed and pathways for ER–mitochondrial crosstalk pertinent to a number of cell death stimuli are discussed.
Abstract: Apoptotic programmed cell death pathways are activated by a diverse array of cell extrinsic and intrinsic signals, most of which are ultimately coupled to the activation of effector caspases. In many instances, this involves an obligate propagation through mitochondria, causing egress of critical proapoptotic regulators to the cytosol. Central to the regulation of the mitochondrial checkpoint is a complex three-way interplay between members of the BCL-2 family, which are comprised of an antiapoptotic subgroup including BCL-2 itself, and the proapoptotic BAX,BAK and BH3-domain-only subgroups. Constituents of all three of these BCL-2 classes, however, also converge on the endoplasmic reticulum (ER), an organelle whose critical contributions to apoptosis is only now becoming apparent. In addition to propagating death-inducing stress signals itself, the ER also contributes in a fundamental way to Fas-mediated apoptosis and to p53-dependent pathways resulting from DNA damage and oncogene expression. Mobilization of ER calcium stores can initiate the activation of cytoplasmic death pathways as well as sensitize mitochondria to direct proapoptotic stimuli. Additionally, the existence of BCL-2-regulated initiator procaspase activation complexes at the ER membrane has also been described. Here, we review the potential underlying mechanisms involved in these events and discuss pathways for ER-mitochondrial crosstalk pertinent to a number of cell death stimuli.
731 citations
••
TL;DR: The data are consistent with the view that N/ Sub 2/O is an obligatory intermediate in the reduction of NO/sub 2//sup -/ to N/ sub 2/ in all of the three organisms studied.
730 citations
••
TL;DR: A geo-statistical model is developed to estimate the volume of global lakes with a surface area of at least 10 ha based on the surrounding terrain information and calculates mean and median hydraulic residence times for all lakes to be 1,834 days and 456 days, respectively.
Abstract: Lakes are key components of biogeochemical and ecological processes, thus knowledge about their distribution, volume and residence time is crucial in understanding their properties and interactions within the Earth system. However, global information is scarce and inconsistent across spatial scales and regions. Here we develop a geo-statistical model to estimate the volume of global lakes with a surface area of at least 10 ha based on the surrounding terrain information. Our spatially resolved database shows 1.42 million individual polygons of natural lakes with a total surface area of 2.67 × 106 km2 (1.8% of global land area), a total shoreline length of 7.2 × 106 km (about four times longer than the world’s ocean coastline) and a total volume of 181.9 × 103 km3 (0.8% of total global non-frozen terrestrial water stocks). We also compute mean and median hydraulic residence times for all lakes to be 1,834 days and 456 days, respectively. Lakes play a key role in our ecosystems and thus it is vital to understand their distribution and volume. Here, the authors present a new global lake database (HydroLAKES) and develop a new geo-statistical model to show global lake area, shoreline length, water volume and hydraulic residence times.
729 citations
Authors
Showing all 73373 results
Name | H-index | Papers | Citations |
---|---|---|---|
Karl J. Friston | 217 | 1267 | 217169 |
Yi Chen | 217 | 4342 | 293080 |
Yoshua Bengio | 202 | 1033 | 420313 |
Irving L. Weissman | 201 | 1141 | 172504 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Lewis C. Cantley | 196 | 748 | 169037 |
Martin White | 196 | 2038 | 232387 |
Michael Marmot | 193 | 1147 | 170338 |
Michael A. Strauss | 185 | 1688 | 208506 |
Alan C. Evans | 183 | 866 | 134642 |
Douglas R. Green | 182 | 661 | 145944 |
David A. Weitz | 178 | 1038 | 114182 |
David L. Kaplan | 177 | 1944 | 146082 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Feng Zhang | 172 | 1278 | 181865 |