McGill University

About: McGill University is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 72688 authors who have published 162565 publications receiving 6966523 citations. The organization is also known as: Royal institution of advanced learning & University of McGill College.

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009.

Abstract: The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with the International Society for Bipolar Disorders (ISBD), reviews new evidence and is designed to be used in conjunction with the previous publications. The recommendations for the management of acute mania remain mostly unchanged. Lithium, valproate, and several atypical antipsychotics continue to be first-line treatments for acute mania. Tamoxifen is now suggested as a third-line augmentation option. The combination of olanzapine and carbamazepine is not recommended. For the management of bipolar depression, lithium, lamotrigine, and quetiapine monotherapy, olanzapine plus selective serotonin reuptake inhibitor (SSRI), and lithium or divalproex plus SSRI/bupropion remain first-line options. New data support the use of adjunctive modafinil as a second-line option, but also indicate that aripiprazole should not be used as monotherapy for bipolar depression. Lithium, lamotrigine, valproate, and olanzapine continue to be first-line options for maintenance treatment of bipolar disorder. New data support the use of quetiapine monotherapy and adjunctive therapy for the prevention of manic and depressive events, aripiprazole monotherapy for the prevention of manic events, and risperidone long-acting injection monotherapy and adjunctive therapy, and adjunctive ziprasidone for the prevention of mood events. Bipolar II disorder is frequently overlooked in treatment guidelines, but has an important clinical impact on patients' lives. This update provides an expanded look at bipolar II disorder.

The State and Social Capital: An Institutional Theory of Generalized Trust

Abstract: The purpose of this article is to present an alternative theory on the generation of social capital. In the discussion about the sources of social capital it has been stressed that generalized trust is built up by the citizens themselves through a culture that permeates the networks and organizations of civil society. Since this approach has run into conceptual problems and has produced only mixed empirical evidence, we like to highlight instead how social capital is embedded in and linked to formal political and legal institutions. Not all political institutions matter equally, however. In fact, we argue that trust thrives most in societies with effective, impartial and fair street-level bureaucracies. The article presents the causal mechanism between these institutional characteristics and generalized trust, and illustrates its validity in a crossnational context.

Electrodynamics of Magnetars: Implications for the Persistent X-ray Emission and Spindown of the Soft Gamma Repeaters and Anomalous X-ray Pulsars

Abstract: (ABBREVIATED) We consider the structure of neutron star magnetospheres threaded by large-scale electrical currents, and the effect of resonant Compton scattering by the charge carriers (both electrons and ions) on the emergent X-ray spectra and pulse profiles. In the magnetar model for the SGRs and AXPs, these currents are maintained by magnetic stresses acting deep inside the star. We construct self-similar, force-free equilibria of the current-carrying magnetosphere with a power-law dependence of magnetic field on radius, B ~ r^(-2-p), and show that a large-scale twist softens the radial dependence to p < 1. The spindown torque acting on the star is thereby increased in comparison with a vacuum dipole. We comment on the strength of the surface magnetic field in the SGR and AXP sources, and the implications of this model for the narrow measured distribution of spin periods. A magnetosphere with a strong twist, B_\phi/B_\theta = O(1) at the equator, has an optical depth ~ 1 to resonant cyclotron scattering, independent of frequency (radius), surface magnetic field strength, or charge/mass ratio of the scattering charge. When electrons and ions supply the current, the stellar surface is also heated by the impacting charges at a rate comparable to the observed X-ray output of the SGR and AXP sources, if B_{dipole} ~ 10^{14} G. Redistribution of the emerging X-ray flux at the ion and electron cyclotron resonances will significantly modify the emerging pulse profile and, through the Doppler effect, generate a non-thermal tail to the X-ray spectrum. The sudden change in the pulse profile of SGR 1900+14 after the 27 August 1998 giant flare is related to an enhanced optical depth to electron cyclotron scattering, resulting from a sudden twist imparted to the external magnetic field.