Pompeu Fabra University

About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.

TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity.

Abstract: Autoregulation of the ciliary beat frequency (CBF) has been proposed as the mechanism used by epithelial ciliated cells to maintain the CBF and prevent the collapse of mucociliary transport under conditions of varying mucus viscosity. Despite the relevance of this regulatory response to the pathophysiology of airways and reproductive tract, the underlying cellular and molecular aspects remain unknown. Hamster oviductal ciliated cells express the transient receptor potential vanilloid 4 (TRPV4) channel, which is activated by increased viscous load involving a phospholipase A2–dependent pathway. TRPV4-transfected HeLa cells also increased their cationic currents in response to high viscous load. This mechanical activation is prevented in native ciliated cells loaded with a TRPV4 antibody. Application of the TRPV4 synthetic ligand 4α-phorbol 12,13-didecanoate increased cationic currents, intracellular Ca2+, and the CBF in the absence of a viscous load. Therefore, TRPV4 emerges as a candidate to participate in the coupling of fluid viscosity changes to the generation of the Ca2+ signal required for the autoregulation of CBF.

Mapping Living Labs in the Landscape of Innovation Methodologies

Abstract: User involvement can take a variety of forms. Some instances position the user as the main creator, in the case of lead users (von Hippel, 1986; tinyurl.com/94oqoek) or open source communities. Others see participants operating as co-creators in practices such as design thinking (Brown, 2008; tinyurl.com/y9ehqt5). On the other end of the spectrum, participatory or user-centered design treats users as passive subjects whose insights are captured and introduced in the innovation process, such as in applied ethnography, usability, human interaction, or market validation exercises.

The intention behind web queries

Abstract: The identification of the user’s intention or interest through queries that they submit to a search engine can be very useful to offer them more adequate results. In this work we present a framework for the identification of user’s interest in an automatic way, based on the analysis of query logs. This identification is made from two perspectives, the objectives or goals of a user and the categories in which these aims are situated. A manual classification of the queries was made in order to have a reference point and then we applied supervised and unsupervised learning techniques. The results obtained show that for a considerable amount of cases supervised learning is a good option, however through unsupervised learning we found relationships between users and behaviors that are not easy to detect just taking the query words. Also, through unsupervised learning we established that there are categories that we are not able to determine in contrast with other classes that were not considered but naturally appear after the clustering process. This allowed us to establish that the combination of supervised and unsupervised learning is a good alternative to find user’s goals. From supervised learning we can identify the user interest given certain established goals and categories; on the other hand, with unsupervised learning we can validate the goals and categories used, refine them and select the most appropriate to the user’s needs.

Foundations of MIMO Communication

Abstract: Understand the fundamentals of wireless and MIMO communication with this accessible and comprehensive text. Viewing the subject through an information theory lens, but also drawing on other perspectives, it provides a sound treatment of the key concepts underpinning contemporary wireless communication and MIMO, all the way to massive MIMO. Authoritative and insightful, it includes over 330 worked examples and 450 homework problems, with solutions and MATLAB code and data available online. Altogether, this is an excellent resource for instructors and graduate students, as well as an outstanding reference for researchers and practicing engineers.

Firms, Destinations, and Aggregate Fluctuations

Abstract: This paper uses a database covering the universe of French firms for the period 1990- 2007 to provide a forensic account of the role of individual firms in generating aggregate fluctuations. We set up a simple multi-sector model of heterogeneous firms selling to multiple markets to motivate a theoretically-founded decomposition of firms' annual sales growth rate into different components. We find that the firm-specific component contributes substantially to aggregate sales volatility, mattering about as much as the components capturing shocks that are common across firms within a sector or country. We then decompose the firm-specific component to provide evidence on two mechanisms that generate aggregate fluctuations from microeconomic shocks highlighted in the recent literature: (i) when the firm size distribution is fat-tailed, idiosyncratic shocks to large firms directly contribute to aggregate fluctuations; and (ii) aggregate fluctuations can arise from idiosyncratic shocks due to input-output linkages across the economy. Firm linkages are approximately three times as important as the direct effect of firm shocks in driving aggregate fluctuations.