Institution
Pompeu Fabra University
Education•Barcelona, Spain•
About: Pompeu Fabra University is a education organization based out in Barcelona, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 8093 authors who have published 23570 publications receiving 858431 citations. The organization is also known as: Universitat Pompeu Fabra & UPF.
Topics: Population, Context (language use), Gene, Computer science, Politics
Papers published on a yearly basis
Papers
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TL;DR: Control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood, were maintained and the major features of the transgenic phenotype were rescued in these mice.
Abstract: Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene present various alterations in brain morphogenesis. They present also learning impairments modeling those encountered in Down syndrome. Previous MRI and histological analyses of a transgenic mice generated using a human YAC construct that contains five genes including DYRK1A reveal that DYRK1A is involved, during development, in the control of brain volume and cell density of specific brain regions. Gene dosage correction induces a rescue of the brain volume alterations. DYRK1A is also involved in the control of synaptic plasticity and memory consolidation. Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice. Epigallocatechin gallate (EGCG) — a member of a natural polyphenols family, found in great amount in green tea leaves — is a specific and safe DYRK1A inhibitor. We maintained control and transgenic mice overexpressing DYRK1A on two different polyphenol-based diets, from gestation to adulthood. The major features of the transgenic phenotype were rescued in these mice.
190 citations
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TL;DR: In this article, the authors compare different synchronization measures with respect to their ability to distinguish between different levels of coupling and their robustness against noise and show that the measure to be applied to a certain task can not be chosen according to a fixed criterion but rather pragmatically as the measure which most reliably yields plausible information in test applications, although certain dynamical features of a system under investigation may render certain measures more suitable than others.
190 citations
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22 Sep 2014TL;DR: In this article, the authors present a theory of natural knowledge and its application in discourse, knowledge, and social cognition, including language, discourse, and knowledge, as well as knowledge, knowledge and culture.
Abstract: 1. Introduction 2. Elements of a theory of natural knowledge 3. Discourse, knowledge and cognition 4. Discourse, knowledge and social cognition 5. Discourse, knowledge and society 6. Discourse, knowledge and culture 7. Language, discourse and knowledge 8. Conclusions.
190 citations
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TL;DR: It is concluded that presynaptic PAC1-mediated signaling at the mossy fiber synapse is involved in both LTP and hippocampus-dependent associative learning.
Abstract: The pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PAC1) is a G-protein-coupled receptor binding the strongly conserved neuropeptide PACAP with 1000-fold higher affinity than the related peptide vasoactive intestinal peptide. PAC1-mediated signaling has been implicated in neuronal differentiation and synaptic plasticity. To gain further insight into the biological significance of PAC1-mediated signaling in vivo, we generated two different mutant mouse strains, harboring either a complete or a forebrain-specific inactivation of PAC1. Mutants from both strains show a deficit in contextual fear conditioning, a hippocampus-dependent associative learning paradigm. In sharp contrast, amygdala-dependent cued fear conditioning remains intact. Interestingly, no deficits in other hippocampus-dependent tasks modeling declarative learning such as the Morris water maze or the social transmission of food preference are observed. At the cellular level, the deficit in hippocampus-dependent associative learning is accompanied by an impairment of mossy fiber long-term potentiation (LTP). Because the hippocampal expression of PAC1 is restricted to mossy fiber terminals, we conclude that presynaptic PAC1-mediated signaling at the mossy fiber synapse is involved in both LTP and hippocampus-dependent associative learning.
190 citations
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Family Research Institute1, Lawrence Berkeley National Laboratory2, Technion – Israel Institute of Technology3, European Institute of Oncology4, University of Turin5, Tel Aviv University6, Sheba Medical Center7, Pomeranian Medical University8, National Institutes of Health9, University of Pennsylvania10, Novartis11, Netherlands Cancer Institute12, Erasmus University Rotterdam13, Leiden University14, Radboud University Nijmegen15, Utrecht University16, University of Amsterdam17, VU University Amsterdam18, Maastricht University19, University of Cambridge20, Central Manchester University Hospitals NHS Foundation Trust21, The Royal Marsden NHS Foundation Trust22, Guy's and St Thomas' NHS Foundation Trust23, St James's University Hospital24, Princess Anne Hospital25, Newcastle upon Tyne Hospitals NHS Foundation Trust26, Royal Devon and Exeter Hospital27, University of Helsinki28, Mayo Clinic29, University of Kansas30, University of Pisa31, University of Gothenburg32, Uppsala University33, Karolinska Institutet34, German Cancer Research Center35, Memorial Hospital of South Bend36, Complutense University of Madrid37, University of Zaragoza38, University of Rostock39, University of Hamburg40, University of Michigan41, Memorial Sloan Kettering Cancer Center42, Pompeu Fabra University43, Latvian Biomedical Research and Study centre44, University of Utah45, Cancer Prevention Institute of California46, Harvard University47, University of Melbourne48, Fox Chase Cancer Center49, University of Cologne50, Technische Universität München51, University of Kiel52, University of Ulm53, Charité54, Heidelberg University55, University of Düsseldorf56, University of Paris57, University of Lyon58, University of Franche-Comté59, QIMR Berghofer Medical Research Institute60, New York University61
TL;DR: Cell biological analysis of the protein product suggests a function in regulating development of the mammary gland and genetic analysis identifies the HMMR gene as a modifier of the breast cancer risk associated with BRCA1 gene mutation.
Abstract: Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.
190 citations
Authors
Showing all 8248 results
Name | H-index | Papers | Citations |
---|---|---|---|
Andrei Shleifer | 171 | 514 | 271880 |
Paul Elliott | 153 | 773 | 103839 |
Bert Brunekreef | 124 | 806 | 81938 |
Philippe Aghion | 122 | 507 | 73438 |
Anjana Rao | 118 | 337 | 61395 |
Jordi Sunyer | 115 | 798 | 57211 |
Kenneth J. Arrow | 113 | 411 | 111221 |
Xavier Estivill | 110 | 673 | 59568 |
Roderic Guigó | 108 | 304 | 106914 |
Mark J. Nieuwenhuijsen | 107 | 647 | 49080 |
Jordi Alonso | 107 | 523 | 64058 |
Alfonso Valencia | 106 | 542 | 55192 |
Luis Serrano | 105 | 452 | 42515 |
Vadim N. Gladyshev | 102 | 490 | 34148 |
Josep M. Antó | 100 | 493 | 38663 |