Shahid Beheshti University of Medical Sciences and Health Services

About: Shahid Beheshti University of Medical Sciences and Health Services is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Medicine. The organization has 19456 authors who have published 33659 publications receiving 365676 citations.

A retrospective 7-years study of aluminum phosphide poisoning in Tehran: opportunities for prevention

Abstract: The objective of this study was to survey aluminum phosphide (AIP) poisoning in a referral poisoning hospital in Tehran servicing an estimation of 10,000,000 populations Records of all patients admitted and hospitalized during a period of 7 years from January 2000 to January 2007 were collected and analyzed according to gender, age, cause of intoxication, amount of AIP consumed, route of exposure, time between exposure and onset of treatment, signs and symptoms of intoxication at admission, therapeutic intervention, laboratory tests, and outcome During the studied years, 471 patients were admitted to the hospital with AIP poisoning; 50% of them were men The overall case fatality ratio was 31% The mean age was 271 years, and most of the patients were between 20 and 40 years old Self-poisoning was observed in 93% of cases The average ingested dose was 51 g, and most of the patients (73%) consumed 1–3 tablets of AIP A wide range of symptoms and signs was seen on admission, but the most common one was cardiovascular manifestations (7812%) The majority (65%) of patients were from Tehran Poisoning in spring and winter (34% and 24%, respectively) was more common than other seasons Gastric decontamination with potassium permanganate, and administration of calcium gluconate, magnesium sulfate, sodium bicarbonate, and charcoal were considered for most of the patients Mean arterial blood pH was 723 and bicarbonate concentration was 127 mEq/L One-hundred percent of patients with blood pH <7 died and 100% of patients with blood pH ≥ 735 survived Electrocardiogram (EKG) abnormalities were noted in 656% of cases There was a significant difference between survival and non-survival according to pH, HCO3 concentration, and EKG abnormality Even without an increase in resources, there appears to be significant opportunities for reducing mortality by better medical management and further restrictions on the AIP tablets usage Arterial blood pH seems to be a prognostic factor for the outcome of AIP-poisoned patients

Glassy carbon electrode modified with 3D graphene–carbon nanotube network for sensitive electrochemical determination of methotrexate

Abstract: In the present study, a 3D porous graphene-carbon nanotube (G-CNT) network is successfully constructed on the surface of glassy carbon electrode (GCE) by electrochemical co-deposition from a concentrated graphene dispersion. The large accessible surface area provided by the interpenetrated graphene backbone in one hand and the enhanced electrical conductivity of the 3D network by incorporating CNTs on the other hand, dramatically improved the electrochemical performance of GCE in determination of Methotrexate (MTX) as an important electroactive drug compound. Under the optimum conditions, the electrode modification led to a significant increase in the anodic peak current (∼25 times) along with a considerable shift in the peak potential (∼111 mV). Voltammetric investigations revealed that the proposed method can determine MTX in a wide dynamic linear range with a low detection limit of 70 nM. Moreover, good sensitivity and high accuracy of the prepared modified electrode in voltammetric detections of MTX, which was further confirmed by UV–vis spectroccopy and HPLC methods, make it very suitable for accurate determinations of MTX in pharmaceutical formulations (commercial tablets) and clinical preparations (blood serum) with excellent recoveries.

Inheritance Pattern and Clinical Aspects of 93 Iranian Patients with Chronic Granulomatous Disease

Abstract: Background Chronic granulomatous disease (CGD) is a rare immunodeficiency due to a genetic defect in one of the NADPH-oxidase components. We studied CGD inheritance forms (autosomal recessive (AR) or X-linked (XL)) and AR-CGD subtypes in Iran. Methods Clinical and functional investigations were conducted in 93 Iranian CGD patients from 75 families. Results Most of the patients were AR-CGD (87.1%). This was related to consanguineous marriages (p= 0.001). The age of onset of symptoms and diagnosis were lower in XL-CGD compared with AR-CGD (p< 0.0001 for both). Among AR-CGD patients, p47phox defect was the predominant subtype (55.5%). The most common clinical features in patients were lymphadenopathy (65.6%) and pulmonary involvement (57%). XL