Technical University of Dortmund

About: Technical University of Dortmund is a education organization based out in Dortmund, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Context (language use) & Large Hadron Collider. The organization has 13028 authors who have published 27666 publications receiving 615557 citations. The organization is also known as: Dortmund University & University of Dortmund.

Pionic parton distributions revisited

Abstract: Using constituent quark model constraints we calculate the gluon and sea–quark content of pions solely in terms of their valence density (fixed by \(\pi N\) Drell–Yan data) and the known sea and gluon distributions of the nucleon, using the most recent updated valence–like input parton densities of the nucleon. The resulting small–x dynamical QCD predictions for \(g^{\pi}(x,Q^2)\) and \(\bar{q} ^{\pi}(x,Q^2)\) are unique and parameter free. Simple analytic parametrizations of the resulting parton distributions of the pion are presented in LO and NLO. These results and parametrizations will be important, among other things, for updated formulations of the parton distributions of real and virtual photons.

RabGEFs are a major determinant for specific Rab membrane targeting.

Abstract: Eukaryotic cells critically depend on the correct regulation of intracellular vesicular trafficking to transport biological material. The Rab subfamily of small guanosine triphosphatases controls these processes by acting as a molecular on/off switch. To fulfill their function, active Rab proteins need to localize to intracellular membranes via posttranslationally attached geranylgeranyl lipids. Each member of the manifold Rab family localizes specifically to a distinct membrane, but it is unclear how this specific membrane recruitment is achieved. Here, we demonstrate that Rab-activating guanosine diphosphate/guanosine triphosphate exchange factors (GEFs) display the minimal targeting machinery for recruiting Rabs from the cytosol to the correct membrane using the Rab-GEF pairs Rab5A–Rabex-5, Rab1A-DrrA, and Rab8-Rabin8 as model systems. Specific mistargeting of Rabex-5/DrrA/Rabin8 to mitochondria led to catalytic recruitment of Rab5A/Rab1A/Rab8A in a time-dependent manner that required the catalytic activity of the GEF. Therefore, RabGEFs are major determinants for specific Rab membrane targeting.

Two-variable logic on data words

Abstract: In a data word each position carries a label from a finite alphabet and a data value from some infinite domain. This model has been already considered in the realm of semistructured data, timed automata, and extended temporal logics.This article shows that satisfiability for the two-variable fragment FO2(∼,