Tel Aviv University

About: Tel Aviv University is a education organization based out in Tel Aviv, Israel. It is known for research contribution in the topics: Population & Medicine. The organization has 47791 authors who have published 115959 publications receiving 3904391 citations. The organization is also known as: TAU & Universiṭat Tel-Aviv.

The MLL recombinome of acute leukemias in 2017

Abstract: Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.

Fiat-Shamir with Aborts: Applications to Lattice and Factoring-Based Signatures

Abstract: We demonstrate how the framework that is used for creating efficient number-theoretic ID and signature schemes can be transferred into the setting of lattices. This results in constructions of the most efficient to-date identification and signature schemes with security based on the worst-case hardness of problems in ideal lattices. In particular, our ID scheme has communication complexity of around 65,000 bits and the length of the signatures produced by our signature scheme is about 50,000 bits. All prior lattice-based identification schemes required on the order of millions of bits to be transferred, while all previous lattice-based signature schemes were either stateful, too inefficient, or produced signatures whose lengths were also on the order of millions of bits. The security of our identification scheme is based on the hardness of finding the approximate shortest vector to within a factor of $\tilde{O}(n^2)$ in the standard model, while the security of the signature scheme is based on the same assumption in the random oracle model. Our protocols are very efficient, with all operations requiring $\tilde{O}(n)$ time. We also show that the technique for constructing our lattice-based schemes can be used to improve certain number-theoretic schemes. In particular, we are able to shorten the length of the signatures that are produced by Girault's factoring-based digital signature scheme ([10][11][31]).

Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients

Abstract: 2006, there was, no single instrument (questionnaire or scale) for attempting a comprehensive assessment of the wide range of nonmotor symptoms (NMS) of Parkinson's disease (PD). The PD nonmotor group, a multidisciplinary group of experts including patient group representatives developed and validated the NMS screening questionnaire (NMSQuest) comprising 30 items. The NMSQuest is a self completed screening tool designed to draw attention to the presence of NMS. In this paper, we present the results gathered from 545 patients using the definitive version of the NMSQuest highlighting the prevalence of the wide range of NMS flagged in the NMSQuest from consecutive PD patients in an international setting.