Universidade Federal de Mato Grosso

About: Universidade Federal de Mato Grosso is a education organization based out in Cuiabá, Brazil. It is known for research contribution in the topics: Population & Species richness. The organization has 7748 authors who have published 10181 publications receiving 89994 citations.

A abordagem do processo do morrer e da morte feita por docentes em um curso de graduação em enfermagem

Abstract: OBJECTIVE: To analyze the relationship between nursing faculty professional profile and their preparation to teach the topic "death and dying" in undergraduate nursing program. METHODS: A descriptive study was used to collect and analyze data from 34 undergraduate nursing faculty members who answered a questionnaire. RESULTS: The findings did not support the presupposition that faculty maturity and professional experience had better preparation to teach "death and dying" for undergraduate nursing students. Faculty teaching of the topic was theoretical and superficial. CONCLUSION: There is a need for discussion and acceptance that undergraduate faculty members are not well prepared to teach "death and dying" in nursing undergraduate programs as well as to provide human and effective nursing care to those in the process of dying.

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus.

Abstract: Mayaro virus (MAYV) is an arbovirus that circulates in Latin America and is emerging as a potential threat to public health. Infected individuals develop Mayaro fever, a severe inflammatory disease characterized by high fever, rash, arthralgia, myalgia and headache. The disease is often associated with a prolonged arthralgia mediated by a chronic inflammation that can last months. Although the immune response against other arboviruses, such as chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV), has been extensively studied, little is known about the pathogenesis of MAYV infection. In this study, we established models of MAYV infection in macrophages and in mice and found that MAYV can replicate in bone marrow-derived macrophages and robustly induce expression of inflammasome proteins, such as NLRP3, ASC, AIM2, and Caspase-1 (CASP1). Infection performed in macrophages derived from Nlrp3-/-, Aim2-/-, Asc-/-and Casp1/11-/-mice indicate that the NLRP3, but not AIM2 inflammasome is essential for production of inflammatory cytokines, such as IL-1β. We also determined that MAYV triggers NLRP3 inflammasome activation by inducing reactive oxygen species (ROS) and potassium efflux. In vivo infections performed in inflammasome-deficient mice indicate that NLRP3 is involved with footpad swelling, inflammation and pain, establishing a role of the NLRP3 inflammasome in the MAYV pathogenesis. Accordingly, we detected higher levels of caspase1-p20, IL-1β and IL-18 in the serum of MAYV-infected patients as compared to healthy individuals, supporting the participation of the NLRP3-inflammasome during MAYV infection in humans.

Gradient Ricci Solitons with Structure of Warped Product

Abstract: In this paper we consider semi-Riemannian warped product gradient Ricci solitons. We prove that the potential function depends only on the base and the fiber is necessarily Einstein manifold. We provide all such solutions in the case of steady gradient Ricci solitons when the base is conformal to an n-dimensional pseudo-Euclidean space, invariant under the action of an (n − 1)-dimensional translation group, and the fiber is Ricci-flat.