Universidade Federal de Mato Grosso

About: Universidade Federal de Mato Grosso is a education organization based out in Cuiabá, Brazil. It is known for research contribution in the topics: Population & Species richness. The organization has 7748 authors who have published 10181 publications receiving 89994 citations.

Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study)

Abstract: This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Resveratrol and Brain Mitochondria: a Review

Abstract: Resveratrol (3,4',5-trihydroxystilbene; C14H12O3) is a polyphenolic phytoalexin found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an antioxidant, anti-inflammatory, anti-apoptotic, and anticancer agent. Moreover, it has been reported that resveratrol modulates mitochondrial function, redox biology, and dynamics in both in vitro and in vivo experimental models. Resveratrol also attenuates mitochondrial impairment induced by certain stressors. Resveratrol upregulates, for example, mitochondria-located antioxidant enzymes, decreasing the production of reactive species by these organelles. Resveratrol also triggers mitochondrial biogenesis, ameliorating the mitochondria-related bioenergetics status in mammalian cells. In the present work, we discuss about the effects of resveratrol on brain mitochondria. Brain cells (both neuronal and glial) are susceptible to mitochondrial dysfunction due to their high demand for adenosine triphosphate (ATP). Additionally, brain cells consume oxygen (O2) at very high rates, leading to a proportionally high mitochondrial production of reactive species. Therefore, strategies focusing on the maintenance of mitochondrial function in these cell types are of pharmacological interest in the case of neurodegenerative diseases, which involve mitochondrial impairment and increased generation of reactive species, leading to neuroinflammation and cell death. The mechanism by which resveratrol protects mitochondrial function and dynamics is not completely understood, and further research would be necessary in order to investigate exactly how resveratrol affects mitochondria-related parameters. Furthermore, it is particularly important because resveratrol is able to induce cytotoxicity depending on its dosage.

Estudo etnobotânico na comunidade de Conceição-Açu (alto da bacia do rio Aricá Açu, MT, Brasil)

Abstract: O presente trabalho tem como objetivo realizar o levantamento etnobotânico de plantas classificadas em diferentes categorias de uso na comunidade de Conceicao-Acu, no municipio de Cuiaba, MT, Brasil e estimar o valor de uso das especies botânicas em matas de galeria. Entrevistas estruturadas e semi-estruturadas, o uso do questionario foram aplicados em 59 residentes adultos de ambos os sexos. Identificou-se as unidades de paisagem: quintais, rocas e matas de galeria e o numero total de especies utilizadas foi de 180. A maioria das plantas foi coletada durante a entrevista e depositadas no Herbario da UFMT. Nos quintais das residencias identificou-se 86 especies, pertencentes a 43 familias, a maioria cultivada e utilizada como alimento (48,1%) e como remedio (44,5%). Nas rocas os principais cultivos sao: Manihot esculenta L. (100%), Carica papaya L. (76,2%), Musa paradisiaca L. (71,4%), Saccharum officinarum L. (57,1%). Na mata de galeria destacou-se a categoria medicinal (65%), com as especies: Copaifera langsdorffii Desf. (2,5), Aspidosperma polyneuron Muell. Arg. (2,5), Hymenaea stignocarpa Mart. (2,33), Diptychandra aurantiaca Tul. (2,0), Cariniana rubra Gardner ex. Miers (20) e as familias botânicas Mimosaceae, Bignoniaceae, Caesalpiniaceae, Fabaceae e Sapindaceae. Os resultados demonstram que a populacao possui vasto conhecimento das plantas e de suas propriedades de cura.