Institution
University College London
Education•London, United Kingdom•
About: University College London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 81105 authors who have published 210603 publications receiving 9868552 citations. The organization is also known as: UCL & University College, London.
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Wageningen University and Research Centre1, University of Edinburgh2, Iowa State University3, University College London4, Agro ParisTech5, Konkuk University6, Institut national de la recherche agronomique7, Aarhus University8, Aberystwyth University9, Seoul National University10, Norwich Research Park11, Wellcome Trust Sanger Institute12, Parco Tecnologico Padano13, University of Copenhagen14, University of Illinois at Urbana–Champaign15, University of Illinois at Chicago16, Agricultural Research Service17, Kansas State University18, Uppsala University19, European Bioinformatics Institute20, United States Department of Agriculture21, Washington University in St. Louis22, University of Kent23, Science for Life Laboratory24, Gyeongsang National University25, Genetic Information Research Institute26, Durham University27, University of California, Davis28, Pennsylvania State University29, University of Minnesota30, Jeju National University31, François Rabelais University32, University of California, Berkeley33, Glasgow Caledonian University34, Leipzig University35, Huazhong Agricultural University36
TL;DR: The assembly and analysis of the genome sequence of a female domestic Duroc pig and a comparison with the genomes of wild and domestic pigs from Europe and Asia reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago.
Abstract: For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
1,189 citations
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University of Cambridge1, Wellcome Trust Centre for Human Genetics2, King's College London3, Western General Hospital4, University of Oxford5, Newcastle University6, University of Bristol7, St George's, University of London8, Wellcome Trust Sanger Institute9, University College London10, Guy's and St Thomas' NHS Foundation Trust11
TL;DR: A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci, and 37 SNPs from these and other loci were tested for association in an independent case-control sample.
Abstract: A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
1,189 citations
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TL;DR: The importance of adequate noise prevention and mitigation strategies for public health is stressed, as Observational and experimental studies have shown that noise exposure leads to annoyance, disturbs sleep and causes daytime sleepiness.
1,189 citations
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TL;DR: The new domain architecture search tool is described and the process of mapping of Gene Ontology terms to InterPro is outlined, and the challenges faced by the resource given the explosive growth in sequence data in recent years are discussed.
Abstract: The InterPro database (http://www.ebi.ac.uk/interpro/) is a freely available resource that can be used to classify sequences into protein families and to predict the presence of important domains and sites. Central to the InterPro database are predictive models, known as signatures, from a range of different protein family databases that have different biological focuses and use different methodological approaches to classify protein families and domains. InterPro integrates these signatures, capitalizing on the respective strengths of the individual databases, to produce a powerful protein classification resource. Here, we report on the status of InterPro as it enters its 15th year of operation, and give an overview of new developments with the database and its associated Web interfaces and software. In particular, the new domain architecture search tool is described and the process of mapping of Gene Ontology terms to InterPro is outlined. We also discuss the challenges faced by the resource given the explosive growth in sequence data in recent years. InterPro (version 48.0) contains 36 766 member database signatures integrated into 26 238 InterPro entries, an increase of over 3993 entries (5081 signatures), since 2012.
1,189 citations
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TL;DR: Thoracic radiotherapy moderately improves survival in patients with limited small-cell lung cancer who are treated with combination chemotherapy, and identification of the optimal combination of chemotherapy and radiotherapy will require further trials.
Abstract: Background. In spite of 16 randomized trials conducted during the past 15 years, the effect of thoracic radiotherapy on the survival of patients with limited small-cell lung cancer remains controversial. The majority of these trials did not have enough statistical power to detect a difference in survival of 5 to 10 percent at five years. This meta-analysis was designed to evaluate the hypothesis that thoracic radiotherapy contributes to a moderate increase in overall survival in limited small-cell lung cancer. Methods. We collected individual data on all patients enrolled before December 1988 in randomized trials comparing chemotherapy alone with chemotherapy combined with thoracic radiotherapy. Trials that included only patients with extensive disease were excluded. Results. The meta-analysis included 13 trials and 2140 patients with limited disease. A total of 433 patients with extensive disease were excluded. Overall, 1862 of 2103 patients who could be evaluated died; the median follow-up peri...
1,188 citations
Authors
Showing all 82293 results
Name | H-index | Papers | Citations |
---|---|---|---|
Trevor W. Robbins | 231 | 1137 | 164437 |
George Davey Smith | 224 | 2540 | 248373 |
Karl J. Friston | 217 | 1267 | 217169 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Cyrus Cooper | 204 | 1869 | 206782 |
David Miller | 203 | 2573 | 204840 |
Mark I. McCarthy | 200 | 1028 | 187898 |
André G. Uitterlinden | 199 | 1229 | 156747 |
Raymond J. Dolan | 196 | 919 | 138540 |
Michael Marmot | 193 | 1147 | 170338 |
Nicholas G. Martin | 192 | 1770 | 161952 |
David R. Williams | 178 | 2034 | 138789 |
John Hardy | 177 | 1178 | 171694 |
James J. Heckman | 175 | 766 | 156816 |
Kay-Tee Khaw | 174 | 1389 | 138782 |