Institution
University of Bedfordshire
Education•Luton, Bedford, United Kingdom•
About: University of Bedfordshire is a education organization based out in Luton, Bedford, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 3860 authors who have published 6079 publications receiving 143448 citations. The organization is also known as: University of Luton.
Papers published on a yearly basis
Papers
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TL;DR: The effects of two different cryopreservation media, cryoprotectant removal method, final sample freezing temperature before LN(2) plunge, warming rate, and the post-thaw incubation time on oocyte viability were investigated.
54 citations
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TL;DR: Both T and IGF-1 increase myogenic commitment after 7-d exposure to a differentiation medium, and the novel system described has the potential for elucidating the pattern of growth factor effects associated with androgens in skeletal muscle.
Abstract: Purpose: The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells. Methods: Differentiation of muscle-derived cells was induced under standard low-serum conditions. Cultures were then exposed to androgen (testosterone (T)) at 50, 100, and 500 nM or IGF-1 (10-50 ng•mL ). Immunocytochemistry and real-time polymerase chain reaction (RT-PCR) were used to assess effects of androgens and IGF-1 after 3-(early) or 7-d (late) muscle differentiation, respectively; RT-PCR was used to quantify the effects on androgen receptor expression. Results: Under low-serum conditions, 3-d exposure to androgens or IGF-1 or both resulted in no significant increase in cellular myogenic commitment. After 7-d exposure, however, T and IGF-1 were both found to increase fusion index with no observable synergistic effect. T also increased IGF-1 mRNA generation (P < 0.0001), whereas exogenous IGF-1 (P < 0.001) reduced IGF-1 mRNA transcription relative to control. The T effect was reversible after treatment with flutamide, an androgen receptor antagonist. Conclusions: Both T and IGF-1 increase myogenic commitment after 7-d exposure to a differentiation medium. With T causing a concomitant increase in IGF-1 mRNA underpinning IGF-1 as a central mediator in the cellular pathways associated with muscle hypertrophy, including those affected by androgens. The novel system described has the potential for elucidating the pattern of growth factor effects associated with androgens in skeletal muscle. © 2012 by the American College of Sports Medicine.
54 citations
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TL;DR: PalmGHG as mentioned in this paper is a GHG calculator using the life cycle assessment ap-proach to quantify major sources of emissions and sequestration for individual palm oil mills and their supply base.
54 citations
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TL;DR: The relevance-theoretic view of covert communication in advertising has been explored in this article, where it is argued that cognitive consistency and innate human meta-representational abilities are far more central to a cognitive pragmatic account of advertisements than the notion of covert communications.
54 citations
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TL;DR: The stakeholder community for AOPs, however, is broader than chemical risk assessors, and multi-faceted communication and governance strategies will address these challenges.
54 citations
Authors
Showing all 3892 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jie Zhang | 178 | 4857 | 221720 |
Oscar H. Franco | 111 | 822 | 66649 |
Timothy J. Foster | 98 | 420 | 32338 |
Christopher P. Denton | 95 | 675 | 42040 |
Ian Kimber | 91 | 620 | 28629 |
Michael J. Gidley | 86 | 420 | 24313 |
David Carling | 86 | 186 | 45066 |
Anthony Turner | 79 | 489 | 24734 |
Rhys E. Green | 78 | 285 | 30428 |
Vijay Kumar Thakur | 74 | 375 | 17719 |
Dave J. Adams | 73 | 283 | 19526 |
Naresh Magan | 72 | 400 | 17511 |
Aedin Cassidy | 70 | 218 | 17788 |
David A. Basketter | 70 | 325 | 16639 |
Richard C. Strange | 67 | 249 | 17805 |