University of California, Irvine

About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.

Acceleration of the contribution of the Greenland and Antarctic ice sheets to sea level rise

Abstract: [1] Ice sheet mass balance estimates have improved substantially in recent years using a variety of techniques, over different time periods, and at various levels of spatial detail. Considerable disparity remains between these estimates due to the inherent uncertainties of each method, the lack of detailed comparison between independent estimates, and the effect of temporal modulations in ice sheet surface mass balance. Here, we present a consistent record of mass balance for the Greenland and Antarctic ice sheets over the past two decades, validated by the comparison of two independent techniques over the last 8 years: one differencing perimeter loss from net accumulation, and one using a dense time series of time-variable gravity. We find excellent agreement between the two techniques for absolute mass loss and acceleration of mass loss. In 2006, the Greenland and Antarctic ice sheets experienced a combined mass loss of 475 ± 158 Gt/yr, equivalent to 1.3 ± 0.4 mm/yr sea level rise. Notably, the acceleration in ice sheet loss over the last 18 years was 21.9 ± 1 Gt/yr2 for Greenland and 14.5 ± 2 Gt/yr2 for Antarctica, for a combined total of 36.3 ± 2 Gt/yr2. This acceleration is 3 times larger than for mountain glaciers and ice caps (12 ± 6 Gt/yr2). If this trend continues, ice sheets will be the dominant contributor to sea level rise in the 21st century.

Genome-wide association study identifies 30 loci associated with bipolar disorder

Abstract: Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10-8) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.

Work Role Transitions: A Study of American Expatriate Managers in Japan

Abstract: Throughout the course of a career, an individual must make numerous role transitions, instigated through such events as overseas transfers, domestic transfers, promotions, company reorganizations, and inter-company job changes. This paper examines the relationships between several variables and work role transition in the case of an overseas assignment to Japan. Role ambiguity and role discretion were found to influence work adjustment, while predeparture knowledge, association with local nationals, and family's adjustment were found to correlate with general adjustment of American expatriate managers in Japan.