Institution
University of California, Irvine
Education•Irvine, California, United States•
About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.
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TL;DR: The many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules make it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.
Abstract: Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single stereoisomers of this important structural motif. Here we discuss the many catalytic enantioselective reactions developed during the past decade for the synthesis of single stereoisomers of such organic molecules. This progress now makes it possible to incorporate quaternary stereocentres selectively in many organic molecules that are useful in medicine, agriculture and potentially other areas such as flavouring, fragrances and materials.
662 citations
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25 Apr 2004TL;DR: Empirical results that suggest that people organize their work in terms of much larger and thematically connected units of work are presented, and it is argued that design of information technology needs to support people's continual switching between working spheres.
Abstract: Most current designs of information technology are based on the notion of supporting distinct tasks such as document production, email usage, and voice communication. In this paper we present empirical results that suggest that people organize their work in terms of much larger and thematically connected units of work. We present results of fieldwork observation of information workers in three different roles: analysts, software developers, and managers. We discovered that all of these types of workers experience a high level of discontinuity in the execution of their activities. People average about three minutes on a task and somewhat more than two minutes using any electronic tool or paper document before switching tasks. We introduce the concept of working spheres to explain the inherent way in which individuals conceptualize and organize their basic units of work. People worked in an average of ten different working spheres. Working spheres are also fragmented; people spend about 12 minutes in a working sphere before they switch to another. We argue that design of information technology needs to support people's continual switching between working spheres.
662 citations
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TL;DR: Findings indicate that glucocorticoid effects on memory consolidation are mediated, in part, by an activation of GRs in the amygdala and that the effects require b-adrenergic activity in the BLA, which is in agreement with the general hypothesis that theBLA integrates hormonal and neuromodulatory influences onMemory consolidation.
662 citations
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TL;DR: PegIntron alfa‐2b maintained the clinical efficacy of interferon alfa'2b while preserving its safety profile and increased virologic response rates after treatment and after follow‐up, as compared with interferons alfa'; however, the higher rate of virolic response during treatment with 1.5 μg/kg peginterferonAlfa‐ 2b in patients infected with genotype 1 and high viral levels warrants further evaluation.
661 citations
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National Center for Atmospheric Research1, Lawrence Berkeley National Laboratory2, Oak Ridge National Laboratory3, Utrecht University4, Columbia University5, Chinese Academy of Sciences6, University of Houston7, University of California, Los Angeles8, California Institute of Technology9, Institute of Arctic and Alpine Research10, Los Alamos National Laboratory11, Harvard University12, Cooperative Institute for Research in Environmental Sciences13, University of Arizona14, University of Colorado Boulder15, Purdue University16, Michigan State University17, Argonne National Laboratory18, University of Michigan19, Auburn University20, Pacific Northwest National Laboratory21, Goddard Space Flight Center22, University of California, Irvine23, Virginia Tech24, University of Sheffield25
TL;DR: The Community Land Model (CLM) is the land component of the Community Earth System Model (CESM) and is used in several global and regional modeling systems.
Abstract: The Community Land Model (CLM) is the land component of the Community Earth System Model (CESM) and is used in several global and regional modeling systems. In this paper, we introduce model developments included in CLM version 5 (CLM5), which is the default land component for CESM2. We assess an ensemble of simulations, including prescribed and prognostic vegetation state, multiple forcing data sets, and CLM4, CLM4.5, and CLM5, against a range of metrics including from the International Land Model Benchmarking (ILAMBv2) package. CLM5 includes new and updated processes and parameterizations: (1) dynamic land units, (2) updated parameterizations and structure for hydrology and snow (spatially explicit soil depth, dry surface layer, revised groundwater scheme, revised canopy interception and canopy snow processes, updated fresh snow density, simple firn model, and Model for Scale Adaptive River Transport), (3) plant hydraulics and hydraulic redistribution, (4) revised nitrogen cycling (flexible leaf stoichiometry, leaf N optimization for photosynthesis, and carbon costs for plant nitrogen uptake), (5) global crop model with six crop types and time‐evolving irrigated areas and fertilization rates, (6) updated urban building energy, (7) carbon isotopes, and (8) updated stomatal physiology. New optional features include demographically structured dynamic vegetation model (Functionally Assembled Terrestrial Ecosystem Simulator), ozone damage to plants, and fire trace gas emissions coupling to the atmosphere. Conclusive establishment of improvement or degradation of individual variables or metrics is challenged by forcing uncertainty, parametric uncertainty, and model structural complexity, but the multivariate metrics presented here suggest a general broad improvement from CLM4 to CLM5.
661 citations
Authors
Showing all 47751 results
Name | H-index | Papers | Citations |
---|---|---|---|
Daniel Levy | 212 | 933 | 194778 |
Rob Knight | 201 | 1061 | 253207 |
Lewis C. Cantley | 196 | 748 | 169037 |
Dennis W. Dickson | 191 | 1243 | 148488 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Joseph Biederman | 179 | 1012 | 117440 |
John R. Yates | 177 | 1036 | 129029 |
John A. Rogers | 177 | 1341 | 127390 |
Avshalom Caspi | 170 | 524 | 113583 |
Yang Gao | 168 | 2047 | 146301 |
Carl W. Cotman | 165 | 809 | 105323 |
John H. Seinfeld | 165 | 921 | 114911 |
Gregg C. Fonarow | 161 | 1676 | 126516 |
Jerome I. Rotter | 156 | 1071 | 116296 |
David Cella | 156 | 1258 | 106402 |