Institution
University of California, Irvine
Education•Irvine, California, United States•
About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The neuronal thrombospondin receptor involved in CNS synapse formation is identified as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin and suggested that gapapentin may function therapeutically by blocking new synapses formation.
699 citations
••
University of Mainz1, University of Delaware2, University of California, Irvine3, University of California, Berkeley4, University of Wuppertal5, Université libre de Bruxelles6, University of Wisconsin-Madison7, Uppsala University8, Stockholm University9, University of Mons-Hainaut10, Lawrence Berkeley National Laboratory11, Pennsylvania State University12, Vrije Universiteit Brussel13, Imperial College London14, University of Wisconsin–River Falls15
TL;DR: In this article, the authors used pulsed and continuous light sources embedded with the AMANDA neutrino telescope, an array of more than six hundred photomultiplier tubes buried deep in the ice.
Abstract: We have remotely mapped optical scattering and absorption in glacial ice at the South Pole for wavelengths between 313 and 560 nm and depths between 1100 and 2350 m. We used pulsed and continuous light sources embedded with the AMANDA neutrino telescope, an array of more than six hundred photomultiplier tubes buried deep in the ice. At depths greater than 1300 m, both the scattering coefficient and absorptivity follow vertical variations in concentration of dust impurities, which are seen in ice cores from other Antarctic sites and which track climatological changes. The scattering coefficient varies by a factor of seven, and absorptivity (for wavelengths less than ∼450 nm) varies by a factor of three in the depth range between 1300 and 2300 m, where four dust peaks due to stadials in the late Pleistocene have been identified. In our absorption data, we also identify a broad peak due to the Last Glacial Maximum around 1300 m. In the scattering data, this peak is partially masked by scattering on residual air bubbles, whose contribution dominates the scattering coefficient in shallower ice but vanishes at ∼1350 m where all bubbles have converted to nonscattering air hydrates. The wavelength dependence of scattering by dust is described by a power law with exponent -0.90 ± 0.03, independent of depth. The wavelength dependence of absorptivity in the studied wavelength range is described by the sum of two components: a power law due to absorption by dust, with exponent -1.08 ± 0.01 and a normalization proportional to dust concentration that varies with depth; and a rising exponential due to intrinsic ice absorption which dominates at wavelengths greater than ∼500 nm. Copyright 2006 by the American Geophysical Union.
697 citations
••
TL;DR: In this paper, the authors used the Aquarius simulations to show that the most massive subhaloes in galaxy-mass dark matter haloes in Λ cold dark matter (ΛCDM) are grossly inconsistent with the dynamics of the brightest Milky Way dwarf spheroidal galaxies.
Abstract: We use the Aquarius simulations to show that the most massive subhaloes in galaxy-mass dark matter (DM) haloes in Λ cold dark matter (ΛCDM) are grossly inconsistent with the dynamics of the brightest Milky Way dwarf spheroidal galaxies. While the best-fitting hosts of the dwarf spheroidals all have , ΛCDM simulations predict at least 10 subhaloes with Vmax > 25 km s−1. These subhaloes are also among the most massive at earlier times, and significantly exceed the reionization suppression mass back to z∼ 10. No ΛCDM-based model of the satellite population of the Milky Way explains this result. The problem lies in the satellites’ densities: it is straightforward to match the observed Milky Way luminosity function, but doing so requires the dwarf spheroidals to have DM haloes that are a factor of ∼5 more massive than is observed. Independent of the difficulty in explaining the absence of these dense, massive subhaloes, there is a basic tension between the derived properties of the bright Milky Way dwarf spheroidals and ΛCDM expectations. The inferred infall masses of these galaxies are all approximately equal and are much lower than standard ΛCDM predictions for systems with their luminosities. Consequently, their implied star formation efficiencies span over two orders of magnitude, from 0.2 to 20 per cent of baryons converted into stars, in stark contrast with expectations gleaned from more massive galaxies. We explore possible solutions to these problems within the context of ΛCDM and find them to be unconvincing. In particular, we use controlled simulations to demonstrate that the small stellar masses of the bright dwarf spheroidals make supernova feedback an unlikely explanation for their low inferred densities.
697 citations
••
TL;DR: It is found that there is an enormous range of protein abundance and, for identified spots, a good correlation between protein abundance, mRNA abundance, and codon bias.
Abstract: In this study, we examined yeast proteins by two-dimensional (2D) gel electrophoresis and gathered quantitative information from about 1,400 spots. We found that there is an enormous range of protein abundance and, for identified spots, a good correlation between protein abundance, mRNA abundance, and codon bias. For each molecule of well-translated mRNA, there were about 4,000 molecules of protein. The relative abundance of proteins was measured in glucose and ethanol media. Protein turnover was examined and found to be insignificant for abundant proteins. Some phosphoproteins were identified. The behavior of proteins in differential centrifugation experiments was examined. Such experiments with 2D gels can give a global view of the yeast proteome.
696 citations
••
TL;DR: Examination of patterns of systolic and diastolic hypertension by age in the nationally representative National Health and Nutrition Examination Survey (NHANES) III found isolated systolics hypertension was the majority subtype of uncontrolled hypertension in subjects of ages 50 to 59 years, and required greater reduction in syStolic blood pressure in these subjects to reach treatment goal compared with subjects in the younger group.
Abstract: The purpose of the present study was to examine patterns of systolic and diastolic hypertension by age in the nationally representative National Health and Nutrition Examination Survey (NHANES) III...
695 citations
Authors
Showing all 47751 results
Name | H-index | Papers | Citations |
---|---|---|---|
Daniel Levy | 212 | 933 | 194778 |
Rob Knight | 201 | 1061 | 253207 |
Lewis C. Cantley | 196 | 748 | 169037 |
Dennis W. Dickson | 191 | 1243 | 148488 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Joseph Biederman | 179 | 1012 | 117440 |
John R. Yates | 177 | 1036 | 129029 |
John A. Rogers | 177 | 1341 | 127390 |
Avshalom Caspi | 170 | 524 | 113583 |
Yang Gao | 168 | 2047 | 146301 |
Carl W. Cotman | 165 | 809 | 105323 |
John H. Seinfeld | 165 | 921 | 114911 |
Gregg C. Fonarow | 161 | 1676 | 126516 |
Jerome I. Rotter | 156 | 1071 | 116296 |
David Cella | 156 | 1258 | 106402 |