University of California, Irvine

About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.

Redefine statistical significance

Abstract: We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.

Principled design of the modern Web architecture

Abstract: The World Wide Web has succeeded in large part because its software architecture has been designed to meet the needs of an Internet-scale distributed hypermedia application. The modern Web architecture emphasizes scalability of component interactions, generality of interfaces, independent deployment of components, and intermediary components to reduce interaction latency, enforce security, and encapsulate legacy systems. In this article we introduce the Representational State Transfer (REST) architectural style, developed as an abstract model of the Web architecture and used to guide our redesign and definition of the Hypertext Transfer Protocol and Uniform Resource Identifiers. We describe the software engineering principles guiding REST and the interaction constraints chosen to retain those principles, contrasting them to the constraints of other architectural styles. We then compare the abstract model to the currently deployed Web architecture in order to elicit mismatches between the existing protocols and the applications they are intended to support.

The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III

Abstract: The Sloan Digital Sky Survey (SDSS) started a new phase in 2008 August, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the clustering of galaxies and the quasar Lyα forest, and a radial velocity search for planets around ~8000 stars. This paper describes the first data release of SDSS-III (and the eighth counting from the beginning of the SDSS). The release includes five-band imaging of roughly 5200 deg2 in the southern Galactic cap, bringing the total footprint of the SDSS imaging to 14,555 deg2, or over a third of the Celestial Sphere. All the imaging data have been reprocessed with an improved sky-subtraction algorithm and a final, self-consistent photometric recalibration and flat-field determination. This release also includes all data from the second phase of the Sloan Extension for Galactic Understanding and Exploration (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars at both high and low Galactic latitudes. All the more than half a million stellar spectra obtained with the SDSS spectrograph have been reprocessed through an improved stellar parameter pipeline, which has better determination of metallicity for high-metallicity stars.

The Drosophila melanogaster Genetic Reference Panel

Abstract: A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.

Design and evaluation of a wide-area event notification service

Abstract: The components of a loosely coupled system are typically designed to operate by generating and responding to asynchronous events. An event notification service is an application-independent infrastructure that supports the construction of event-based systems, whereby generators of events publish event notifications to the infrastructure and consumers of events subscribe with the infrastructure to receive relevant notifications. The two primary services that should be provided to components by the infrastructure are notification selection (i. e., determining which notifications match which subscriptions) and notification delivery (i.e., routing matching notifications from publishers to subscribers). Numerous event notification services have been developed for local-area networks, generally based on a centralized server to select and deliver event notifications. Therefore, they suffer from an inherent inability to scale to wide-area networks, such as the Internet, where the number and physical distribution of the service's clients can quickly overwhelm a centralized solution. The critical challenge in the setting of a wide-area network is to maximize the expressiveness in the selection mechanism without sacrificing scalability in the delivery mechanism. This paper presents SIENA, an event notification service that we have designed and implemented to exhibit both expressiveness and scalability. We describe the service's interface to applications, the algorithms used by networks of servers to select and deliver event notifications, and the strategies used to optimize performance. We also present results of simulation studies that examine the scalability and performance of the service.