University of California, Irvine

About: University of California, Irvine is a education organization based out in Irvine, California, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 47031 authors who have published 113602 publications receiving 5521832 citations. The organization is also known as: UC Irvine & UCI.

First observation of PeV-energy neutrinos with IceCube

Abstract: We report on the observation of two neutrino-induced events which have an estimated deposited energy in the IceCube detector of 1.04 +/- 0.16 and 1.14 +/- 0.17 PeV, respectively, the highest neutrino energies observed so far. These events are consistent with fully contained particle showers induced by neutral-current nu(e,mu,tau) ((nu) over bar (e,mu,tau)) or charged-current nu(e) ((nu) over bar (e)) interactions within the IceCube detector. The events were discovered in a search for ultrahigh energy neutrinos using data corresponding to 615.9 days effective live time. The expected number of atmospheric background is 0.082 +/- 0.004(stat)(-0.057)(+0.041)(syst). The probability of observing two or more candidate events under the atmospheric background-only hypothesis is 2.9 x 10(-3) (2.8 sigma) taking into account the uncertainty on the expected number of background events. These two events could be a first indication of an astrophysical neutrino flux; the moderate significance, however, does not permit a definitive conclusion at this time.

Organizational routines as a unit of analysis

Abstract: Organizational routines can be conceptualized as generative systems with internal structures and dynamics. In this paper, we propose three different ways that organizational routines can be approached as a unit of analysis. One option is to treat the entire routine as an undifferentiated 'black box'. A second option is to study particular parts of the routine in isolation (e.g. routines as patterns of action). A third option is to study the relationships between these parts and the processes by which the parts change. For some questions, routines can be taken as a unit of analysis without considering their internal structure, but there are many research questions for which it is useful to consider the parts of routines either separately or as they interact. We discuss the importance of understanding the internal structure and dynamics of organizational routines for exploring core organizational phenomena such as stability, change, flexibility, learning and transfer. Copyright 2005, Oxford University Press.

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Abstract: Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD-abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions.

On the limiting aerodynamic roughness of the ocean in very strong winds

Abstract: The aerodynamic friction between air and sea is an important part of the momentum balance in the development of tropical cyclones. Measurements of the drag coefficient, relating the tangential stress ( frictional drag) between wind and water to the wind speed and air density, have yielded reliable information in wind speeds less than 20 m/s ( about 39 knots). In these moderate conditions it is generally accepted that the drag coefficient ( or equivalently, the aerodynamic roughness'') increases with the wind speed. Can one merely extrapolate this wind speed tendency to describe the aerodynamic roughness of the ocean in the extreme wind speeds that occur in hurricanes ( wind speeds greater than 30 m/s)? This paper attempts to answer this question, guided by laboratory extreme wind experiments, and concludes that the aerodynamic roughness approaches a limiting value in high winds. A fluid mechanical explanation of this phenomenon is given.

On Feasibility of Interference Alignment in MIMO Interference Networks

Abstract: We explore the feasibility of interference alignment in signal vector space-based only on beamforming-for K-user MIMO interference channels. Our main contribution is to relate the feasibility issue to the problem of determining the solvability of a multivariate polynomial system which is considered extensively in algebraic geometry. It is well known, e.g., from Bezout's theorem, that generic polynomial systems are solvable if and only if the number of equations does not exceed the number of variables. Following this intuition, we classify signal space interference alignment problems as either proper or improper based on the number of equations and variables. Rigorous connections between feasible and proper systems are made through Bernshtein's theorem for the case where each transmitter uses only one beamforming vector. The multibeam case introduces dependencies among the coefficients of a polynomial system so that the system is no longer generic in the sense required by both theorems. In this case, we show that the connection between feasible and proper systems can be further strengthened (since the equivalency between feasible and proper systems does not always hold) by including standard information theoretic outer bounds in the feasibility analysis.