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Institution

University of California, Santa Barbara

EducationSanta Barbara, California, United States
About: University of California, Santa Barbara is a education organization based out in Santa Barbara, California, United States. It is known for research contribution in the topics: Population & Laser. The organization has 30281 authors who have published 80852 publications receiving 4626827 citations. The organization is also known as: UC Santa Barbara & UCSB.


Papers
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Journal ArticleDOI
TL;DR: Conjugation to iRGD significantly improved the sensitivity of tumor-imaging agents and enhanced the activity of an antitumor drug.

1,004 citations

Journal ArticleDOI
TL;DR: In this paper, the authors proposed a new normalized information distance based on the non-computable notion of Kolmogorov complexity, which minorizes every computable distance in the class (that is, it is universal in that it discovers all computable similarities).
Abstract: A new class of distances appropriate for measuring similarity relations between sequences, say one type of similarity per distance, is studied. We propose a new "normalized information distance," based on the noncomputable notion of Kolmogorov complexity, and show that it is in this class and it minorizes every computable distance in the class (that is, it is universal in that it discovers all computable similarities). We demonstrate that it is a metric and call it the similarity metric . This theory forms the foundation for a new practical tool. To evidence generality and robustness, we give two distinctive applications in widely divergent areas using standard compression programs like gzip and GenCompress. First, we compare whole mitochondrial genomes and infer their evolutionary history. This results in a first completely automatic computed whole mitochondrial phylogeny tree. Secondly, we fully automatically compute the language tree of 52 different languages.

1,002 citations

Journal ArticleDOI
TL;DR: The phylogenetic level at which microbes form meaningful guilds is considered, based on overall life history strategies, and it is suggested that these are associated with deep evolutionary divergences, while much of the species-level diversity probably reflects functional redundancy.
Abstract: A major thrust of terrestrial microbial ecology is focused on understanding when and how the composition of the microbial community affects the functioning of biogeochemical processes at the ecosystem scale (meters-to-kilometers and days-to-years). While research has demonstrated these linkages for physiologically and phylogenetically “narrow” processes such as trace gas emissions and nitrification, there is less conclusive evidence that microbial community composition influences the “broad” processes of decomposition and organic matter turnover in soil. In this paper, we consider how soil microbial community structure influences C-cycling. We consider the phylogenetic level at which microbes form meaningful guilds, based on overall life history strategies, and suggest that these are associated with deep evolutionary divergences, while much of the species-level diversity probably reflects functional redundancy. We then consider under what conditions it is possible for differences among microbes to affect process dynamics, and argue that while microbial community structure may be important in the rate of OM breakdown in the rhizosphere and in detritus, it is likely not important in the mineral soil. In mineral soil, physical access to occluded or sorbed substrates is the rate-limiting process. Microbial community influences on OM turnover in mineral soils are based on how organisms allocate the C they take up—not only do the fates of the molecules differ, but they can affect the soil system differently as well. For example, extracellular enzymes and extracellular polysaccharides can be key controls on soil structure and function. How microbes allocate C may also be particularly important for understanding the long-term fate of C in soil—is it sequestered or not?

1,002 citations

Journal ArticleDOI
TL;DR: The sources of international students' psychological concerns, the reasons for their notable underutilization of existing counseling services, and the ways to provide more culturally sensitive services are examined.
Abstract: International students on the American college campus are a diverse and increasing population whose unique concerns are traditionally overlooked. However, given the evidence that the demands for cultural adjustments frequently place international students at greater risk for various psychological problems than are students in general, it is important that sufficient and readily accessible mental health services be established for them. This article examines the sources of international students' psychological concerns, the reasons for their notable underutilization of existing counseling services, and the ways to provide more culturally sensitive services.

995 citations

Journal ArticleDOI
TL;DR: The data indicate that specific bacterial populations, different from those which predominate in free-living bacterioplankton, develop on marine phytodetrital aggregates.
Abstract: The phylogenetic diversity of macroaggregate-attached vs. free-living marine bacteria, co-occurring in the same water mass, was compared. Bacterial diversity and phylogcnetic identity were inferred by analyzing polymerase chain reaction (PCR) amplified, cloned ribosomal RNA (rRNA) genes. Ribosomal RNA genes from macroaggregatc-associated bacteria were fundamentally different from those of free-living bacterioplankton. Most rRNA types recovered from the free-living bacterioplankton were closely related to a phenotypically undcscribcd (Y Proteobacteria group, previously detected in surface waters of North Pacific and Atlantic central ocean gyres. The results suggest that members of this phylogenetically distinct, (Y proteobacterial group are abundant free-living bactcrioplankters in coastal, as well as open-ocean habitats. In contrast, most macroaggregate-associated rRNA clones were closely related to Cytophuga, Planctomyce.s, or y Proteobacteria, within the domain Bacteria. These data indicate that specific bacterial populations, different from those which predominate in free-living bacterioplankton, develop on marine phytodetrital aggregates. The inferred properties of attached bacterial assemblages have significant implications for models of microbially mediated transformation of particulate organic material.

992 citations


Authors

Showing all 30652 results

NameH-indexPapersCitations
George M. Whitesides2401739269833
Yi Chen2174342293080
Simon D. M. White189795231645
George Efstathiou187637156228
Peidong Yang183562144351
David R. Williams1782034138789
Alan J. Heeger171913147492
Richard H. Friend1691182140032
Jiawei Han1681233143427
Gang Chen1673372149819
Alexander S. Szalay166936145745
Omar M. Yaghi165459163918
Carlos S. Frenk165799140345
Yang Yang1642704144071
Carlos Bustamante161770106053
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023150
2022528
20213,352
20203,653
20193,516