Institution
University of Lausanne
Education•Lausanne, Switzerland•
About: University of Lausanne is a education organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Medicine. The organization has 20508 authors who have published 46458 publications receiving 1996655 citations. The organization is also known as: Université de Lausanne & UNIL.
Topics: Population, Medicine, Context (language use), Gene, Immune system
Papers published on a yearly basis
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University of Lausanne1, Leiden University2, University of California, San Francisco3, University of Pennsylvania4, Norwegian University of Science and Technology5, University of Greifswald6, Federal University of São Paulo7, University of Cambridge8, University of Pittsburgh9, University of Birmingham10, University of Bern11
TL;DR: Endogenous subclinical hyperthyroidism is associated with increased risks of total,CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L.
Abstract: Background Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Methods Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 participants from 6 cohorts with available data, and incident AF was analyzed in 8711 participants from 5 cohorts. Euthyroidism was defined as thyrotropin level between 0.45 and 4.49 mIU/L and endogenous subclinical hyperthyroidism as thyrotropin level lower than 0.45 mIU/L with normal free thyroxine levels, after excluding those receiving thyroid-altering medications. Results Of 52 674 participants, 2188 (4.2%) had subclinical hyperthyroidism. During follow-up, 8527 participants died (including 1896 from CHD), 3653 of 22 437 had CHD events, and 785 of 8711 developed AF. In age- and sex-adjusted analyses, subclinical hyperthyroidism was associated with increased total mortality (hazard ratio [HR], 1.24, 95% CI, 1.06-1.46), CHD mortality (HR, 1.29; 95% CI, 1.02-1.62), CHD events (HR, 1.21; 95% CI, 0.99-1.46), and AF (HR, 1.68; 95% CI, 1.16-2.43). Risks did not differ significantly by age, sex, or preexisting cardiovascular disease and were similar after further adjustment for cardiovascular risk factors, with attributable risk of 14.5% for total mortality to 41.5% for AF in those with subclinical hyperthyroidism. Risks for CHD mortality and AF (but not other outcomes) were higher for thyrotropin level lower than 0.10 mIU/L compared with thyrotropin level between 0.10 and 0.44 mIU/L (for both, P value for trend, ≤.03). Conclusion Endogenous subclinical hyperthyroidism is associated with increased risks of total, CHD mortality, and incident AF, with highest risks of CHD mortality and AF when thyrotropin level is lower than 0.10 mIU/L.
405 citations
TL;DR: Several new functional characteristics of human Na,K-ATPase isozymes are revealed which help to better understand their role in ion homeostasis in different tissues and in digitalis action and toxicity.
404 citations
TL;DR: This paper presents a review of the automated approaches for atlas-based segmentation of magnetic resonance brain images, and aims to point out the strengths and weaknesses of at Atlas-based methods and suggest new research directions.
404 citations
University of Nebraska Medical Center1, National Institutes of Health2, University of Würzburg3, University of British Columbia4, City of Hope National Medical Center5, University of Michigan6, National University of Singapore7, University of Arizona8, University of Barcelona9, University of Oslo10, Oregon Health & Science University11, Cleveland Clinic12, Bosch13, University of Paris14, University of Bologna15, University of Hong Kong16, Claude Bernard University Lyon 117, University of Lausanne18
TL;DR: Gene-expression profiles, immunohistochemistry, and IDH2 mutation analysis in reclassified cases supported the validity of the reclassification of PTCL-NOS cases, and high expression of several signatures associated with the tumor microenvironment was significantly associated with outcome.
404 citations
TL;DR: In this review, an overview of reported analytical methods for the determination of the most commonly used anticancer drugs is given.
404 citations
Authors
Showing all 20911 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peer Bork | 206 | 697 | 245427 |
| Aaron R. Folsom | 181 | 1118 | 134044 |
| Kari Alitalo | 174 | 817 | 114231 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Johan Auwerx | 158 | 653 | 95779 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Matthias Egger | 152 | 901 | 184176 |
| Bart Staels | 152 | 824 | 86638 |
| Fernando Rivadeneira | 146 | 628 | 86582 |
| Christopher George Tully | 142 | 1843 | 111669 |
| Richard S. J. Frackowiak | 142 | 309 | 100726 |
| Peter Timothy Cox | 140 | 1267 | 95584 |
| Jürg Tschopp | 140 | 328 | 86900 |
| Stylianos E. Antonarakis | 138 | 746 | 93605 |
| Michael Weller | 134 | 1105 | 91874 |