University of Ljubljana

About: University of Ljubljana is a education organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 17210 authors who have published 47013 publications receiving 1082684 citations. The organization is also known as: Univerza v Ljubljani.

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Abstract: Overproduction of reactive oxygen and nitrogen species can result from exposure to environmental pollutants, such as ionising and nonionising radiation, ultraviolet radiation, elevated concentrations of ozone, nitrogen oxides, sulphur dioxide, cigarette smoke, asbestos, particulate matter, pesticides, dioxins and furans, polycyclic aromatic hydrocarbons, and many other compounds present in the environment. It appears that increased oxidative/nitrosative stress is often neglected mechanism by which environmental pollutants affect human health. Oxidation of and oxidative damage to cellular components and biomolecules have been suggested to be involved in the aetiology of several chronic diseases, including cancer, cardiovascular disease, cataracts, age-related macular degeneration, and aging. Several studies have demonstrated that the human body can alleviate oxidative stress using exogenous antioxidants. However, not all dietary antioxidant supplements display protective effects, for example, β-carotene for lung cancer prevention in smokers or tocopherols for photooxidative stress. In this review, we explore the increases in oxidative stress caused by exposure to environmental pollutants and the protective effects of antioxidants.

Bioactivation potential of thiophene-containing drugs.

Abstract: Thiophene is a five-membered, sulfur-containing heteroaromatic ring commonly used as a building block in drugs. It is considered to be a structural alert, as its metabolism can lead to the formation of reactive metabolites. Thiophene S-oxides and thiophene epoxides are highly reactive electrophilic thiophene metabolites whose formation is cytochrome P450-dependent. These reactive thiophene-based metabolites are quite often responsible for drug-induced hepatotoxicity. Tienilic acid is an example of a thiophene-based drug that was withdrawn from the market after only a few months of use, due to severe cases of immune hepatitis. However, inclusion of the thiophene moiety in drugs does not necessarily result in toxic effects. The presence of other, less toxic metabolic pathways, as well as an effective detoxification system in our body, protects us from the bioactivation potential of the thiophene ring. Thus, the presence of a structural alert itself is insufficient to predict a compound’s toxicity. The quest...

Lifting Graph Automorphisms by Voltage Assignments

Abstract: The problem of lifting graph automorphisms along covering projections and the analysis of lifted groups is considered in a purely combinatorial setting. The main tools employed are: (1) a systematic use of the fundamental groupoid; (2) unification of ordinary, relative and permutation voltage constructions into the concept of a voltage space; (3) various kinds of invariance of voltage spaces relative to automorphism groups; and (4) investigation of geometry of the lifted actions by means of transversals over a localization set. Some applications of these results to regular maps on surfaces are given. Because of certain natural applications and greater generality, graphs are allowed to have semiedges. This requires careful re-examination of the whole subject and at the same time leads to simplification and generalization of several known results.

HR practices, interpersonal relations, and intrafirm knowledge transfer in knowledge-intensive firms: A social network perspective

Abstract: We adopt the social network perspective to develop a conceptual model and examine the relationship among human resource (HR) practices, interpersonal relations, and intrafirm knowledge transfer in knowledge-intensive firms. Our results indicate that work design, along with training and development HR practices, can shape the structural relation. At the same time, both also exhibit potential for shaping affective and cognitive relations within a firm's social network. While the effects of work design along with training and development HR practices on intrafirm knowledge transfer are primarily mediated by interpersonal relations, we found some evidence for arguing that incentives and motivation HR practices directly affect intrafirm knowledge transfer.