Institution
University of Ljubljana
Education•Ljubljana, Slovenia•
About: University of Ljubljana is a education organization based out in Ljubljana, Slovenia. It is known for research contribution in the topics: Population & Liquid crystal. The organization has 17210 authors who have published 47013 publications receiving 1082684 citations. The organization is also known as: Univerza v Ljubljani.
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TL;DR: The results suggest a model wherein functionally redundant microbial and viral taxa are cycling at the level of viral genotypes and virus-sensitive microbial strains, which contradicts theoretical models as well as the viral–microbial dynamics observed in simple ecosystems.
Abstract: The species composition and metabolic potential of microbial and viral communities are predictable and stable for most ecosystems. This apparent stability contradicts theoretical models as well as the viral-microbial dynamics observed in simple ecosystems, both of which show Kill-the-Winner behavior causing cycling of the dominant taxa. Microbial and viral metagenomes were obtained from four human-controlled aquatic environments at various time points separated by one day to >1 year. These environments were maintained within narrow geochemical bounds and had characteristic species composition and metabolic potentials at all time points. However, underlying this stability were rapid changes at the fine-grained level of viral genotypes and microbial strains. These results suggest a model wherein functionally redundant microbial and viral taxa are cycling at the level of viral genotypes and virus-sensitive microbial strains. Microbial taxa, viral taxa, and metabolic function persist over time in stable ecosystems and both communities fluctuate in a Kill-the-Winner manner at the level of viral genotypes and microbial strains.
382 citations
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TL;DR: Investigation of the ingestion and effects of ground polyethylene terephthalate textile microfibers on the freshwater zooplankton crustacean Daphnia magna found that daphnids were not able to recover from MP exposure after additional 24 h incubation period in a MP free medium with algae.
381 citations
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TL;DR: The in vivo RBP repertoire of the yeast Saccharomyces cerevisiae is determined and the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP, defining the coreRBP repertoire conserved from yeast to man.
Abstract: RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the yeast Saccharomyces cerevisiae and identified 678 RBPs from yeast and additionally 729 RBPs from human hepatocytic HuH-7 cells. Combined analyses of these and recently published data sets define the core RBP repertoire conserved from yeast to man. Conserved RBPs harbour defined repetitive motifs within disordered regions, which display striking evolutionary expansion. Only 60% of yeast and 73% of the human RBPs have functions assigned to RNA biology or structural motifs known to convey RNA binding, and many intensively studied proteins surprisingly emerge as RBPs (termed 'enigmRBPs'), including almost all glycolytic enzymes, pointing to emerging connections between gene regulation and metabolism. Analyses of the mitochondrial hydroxysteroid dehydrogenase (HSD17B10) uncover the RNA-binding specificity of an enigmRBP.
381 citations
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TL;DR: In this article, a systematic review on size effects in manufacturing of metallic components is presented, where the typology of size effects is explained, followed by a description of size effect on strength and tribology, and last three sections describe size effects on formability, forming processes and cutting processes.
381 citations
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French Institute of Health and Medical Research1, University of Paris-Sud2, Humboldt University of Berlin3, University of Pisa4, University of Bergen5, Utrecht University6, University of Ljubljana7, University of Strasbourg8, University of Udine9, University of Buenos Aires10, National and Kapodistrian University of Athens11, Winthrop University12, Queen Mary University of London13, University of Birmingham14
TL;DR: The EULAR SS Patient Reported Index is a very simple index designed to measure patients' symptoms in primary SS and has good construct validity and is well correlated with SSI and PROFAD.
Abstract: Objectives To develop a score for assessment of patients9 symptoms in primary Sjogren9s syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI). Methods Dryness, pain, somatic and mental fatigue were identified as the main symptoms of patients with primary SS, in studies developing the Profile of Fatigue and Discomfort (PROFAD) and Sicca Symptoms Inventory (SSI). It was suspected that a single 0–10 numerical scale for each domain was sufficient to assess these symptoms. These four scales were gathered to form the ESSPRI. 230 patients, from 12 countries completed the ESSPRI, SSI and PROFAD questionnaires and a 0–10 patient global assessment (PGA). Correlations between each symptom and PGA were obtained. Multiple regression modelling, using PGA as ‘gold standard’ was used to select domains and estimate their weights. Results PGA had good correlation with dryness, limb pain, fatigue and mental fatigue (r=0.49–0.59, all p Conclusion ESSPRI is a very simple index designed to measure patients9 symptoms in primary SS. It has good construct validity and is well correlated with SSI and PROFAD. ESSPRI should now be validated for use as an outcome measure in clinical trials.
380 citations
Authors
Showing all 17388 results
Name | H-index | Papers | Citations |
---|---|---|---|
David Miller | 203 | 2573 | 204840 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
James M. Tour | 143 | 859 | 91364 |
Carmen García | 139 | 1503 | 96925 |
Bernt Schiele | 130 | 568 | 70032 |
Vladimir Cindro | 129 | 1157 | 82000 |
Teresa Barillari | 129 | 984 | 78782 |
Sven Menke | 129 | 1121 | 82034 |
Horst Oberlack | 129 | 985 | 80069 |
Hubert Kroha | 129 | 1126 | 80746 |
Peter Schacht | 129 | 1030 | 80092 |
Siegfried Bethke | 129 | 1266 | 103520 |
Igor Mandić | 128 | 1065 | 79498 |
Stefan Kluth | 128 | 1261 | 84534 |
Andrej Gorišek | 128 | 951 | 67830 |