University of Milan

About: University of Milan is a education organization based out in Milan, Italy. It is known for research contribution in the topics: Population & Medicine. The organization has 58413 authors who have published 139784 publications receiving 4636354 citations. The organization is also known as: Università degli Studi di Milano & Statale.

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.

Abstract: Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. However, this idea has been difficult to reconcile with the small fraction of mtDNA so far found to be altered. Here, examination of mtDNA revealed high copy point mutations at specific positions in the control region for replication of human fibroblast mtDNA from normal old, but not young, individuals. Furthermore, in longitudinal studies, one or more mutations appeared in an individual only at an advanced age. Some mutations appeared in more than one individual. Most strikingly, a T414G transversion was found, in a generally high proportion (up to 50 percent) of mtDNA molecules, in 8 of 14 individuals above 65 years of age (57 percent) but was absent in 13 younger individuals.

Evidence for a Canonical Gamma-Ray Burst Afterglow Light Curve in the Swift XRT Data

Abstract: We present new observations of the early X-ray afterglows of the first 27 gamma-ray bursts (GRBs) well observed by the Swift X-Ray Telescope (XRT). The early X-ray afterglows show a canonical behavior, where the light curve broadly consists of three distinct power-law segments: (1) an initial very steep decay (/t � � with 3P � 1 P5), followed by (2) a very shallow decay (0:5P � 2 P1:0), and finally (3) a somewhat steeper decay (1P � 3 P1:5). These power-law segments are separated by two corresponding break times, tbreak;1 P500 s and 10 3 sPtbreak;2P 10 4 s. On top of this canonical behavior, many events have superimposed X-ray flares, which are most likely caused by internal shocks due to long-lasting sporadic activity of the central engine, up to several hours after the GRB. We find that the initial steep decay is consistent with it being the tail of the prompt emission, from photons that are radiated at large angles relative to our line of sight. The first break in the light curve (tbreak;1) takes place when the forward shock emission becomes dominant, with the intermediate shallow flux decay (� 2) likely caused by the continuous energy injection into the external shock. When this energy injection stops, a second break is then observed in the light curve (tbreak;2). This energy injection increases the energy of the afterglow shock by at least a factor of f k4 and augments the already severe requirements for the efficiency of the prompt gamma-ray emission. Subject headingg gamma rays: bursts — radiation mechanisms: nonthermal

ATLAS pixel detector electronics and sensors

Abstract: The silicon pixel tracking system for the ATLAS experiment at the Large Hadron Collider is described and the performance requirements are summarized. Detailed descriptions of the pixel detector electronics and the silicon sensors are given. The design, fabrication, assembly and performance of the pixel detector modules are presented. Data obtained from test beams as well as studies using cosmic rays are also discussed.