Institution
University of Southern California
Education•Los Angeles, California, United States•
About: University of Southern California is a education organization based out in Los Angeles, California, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 73160 authors who have published 169955 publications receiving 7838906 citations. The organization is also known as: USC & University of Southern CA.
Topics: Population, Cancer, Poison control, Medicine, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: The preference for the proper face stimulus by infants who had not seen a real face prior to testing suggests that an unlearned or "evolved" responsiveness to faces may be present in human neonates.
Abstract: Forty newborn infants, median age 9 minutes, turned their eyes and heads to follow a series of moving stimuli. Responsiveness was significantly greater to a proper face pattern than to either of two scrambled versions of the same stimulus or to a blank. The demonstration of such consistent response differences suggests that visual discriminations are being made at this early age. These results imply that organized visual perception is an unlearned capacity of the human organism. The preference for the proper face stimulus by infants who had not seen a real face prior to testing suggests that an unlearned or "evolved" responsiveness to faces may be present in human neonates.
990 citations
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Massachusetts Institute of Technology1, QIMR Berghofer Medical Research Institute2, University of London3, University of California, San Francisco4, Columbia University5, University of Edinburgh6, VU University Amsterdam7, University of Bonn8, University of Washington9, Heidelberg University10, University of Iowa11, University of North Carolina at Chapel Hill12, National Institutes of Health13, Karolinska Institutet14, North Carolina State University15, Harvard University16, University of Lausanne17, University of Southern California18, Howard University19, Rush University Medical Center20, University of Geneva21, University of Sydney22, University of Bristol23, Cardiff University24, Mayo Clinic25, Virginia Commonwealth University26, Leiden University27, Stanford University28
TL;DR: This article conducted a genome-wide association studies (GWAS) mega-analysis for major depressive disorder (MDD) using more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18,759 independent and unrelated subjects of recent European ancestry.
Abstract: Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18 759 independent and unrelated subjects of recent European ancestry (9240 MDD cases and 9519 controls). In the MDD replication phase, we evaluated 554 SNPs in independent samples (6783 MDD cases and 50 695 controls). We also conducted a cross-disorder meta-analysis using 819 autosomal SNPs with P<0.0001 for either MDD or the Psychiatric GWAS Consortium bipolar disorder (BIP) mega-analysis (9238 MDD cases/8039 controls and 6998 BIP cases/7775 controls). No SNPs achieved genome-wide significance in the MDD discovery phase, the MDD replication phase or in pre-planned secondary analyses (by sex, recurrent MDD, recurrent early-onset MDD, age of onset, pre-pubertal onset MDD or typical-like MDD from a latent class analyses of the MDD criteria). In the MDD-bipolar cross-disorder analysis, 15 SNPs exceeded genome-wide significance (P<5 × 10(-8)), and all were in a 248 kb interval of high LD on 3p21.1 (chr3:52 425 083-53 822 102, minimum P=5.9 × 10(-9) at rs2535629). Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits. Therefore, we were unable to identify robust and replicable findings. We discuss what this means for genetic research for MDD. The 3p21.1 MDD-BIP finding should be interpreted with caution as the most significant SNP did not replicate in MDD samples, and genotyping in independent samples will be needed to resolve its status.
989 citations
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TL;DR: Extensions are presented that allow for the effects of uncertainty in knowledge of population size and mutation rates, for variability in population sizes, for regions of different mutation rate, and for inference concerning the coalescence time of the entire population.
Abstract: The paper is concerned with methods for the estimation of the coalescence time (time since the most recent common ancestor) of a sample of intraspecies DNA sequences. The methods take advantage of prior knowledge of population demography, in addition to the molecular data. While some theoretical results are presented, a central focus is on computational methods. These methods are easy to implement, and, since explicit formulae tend to be either unavailable or unilluminating, they are also more useful and more informative in most applications. Extensions are presented that allow for the effects of uncertainty in our knowledge of population size and mutation rates, for variability in population sizes, for regions of different mutation rate, and for inference concerning the coalescence time of the entire population. The methods are illustrated using recent data from the human Y chromosome.
989 citations
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TL;DR: The Program on the Surgical Control of the Hyperlipidemias (POSCH) randomized clinical trial was designed to test whether cholesterol lowering induced by the partial ileal bypass operation would favorably affect overall mortality or mortality due to coronary heart disease.
Abstract: Background and Methods The Program on the Surgical Control of the Hyperlipidemias (POSCH), a randomized clinical trial, was designed to test whether cholesterol lowering induced by the partial ileal bypass operation would favorably affect overall mortality or mortality due to coronary heart disease. The study population consisted of 838 patients (417 in the control group and 421 in the surgery group), both men (90.7 percent) and women, with an average age of 51 years, who had survived a first myocardial infarction. The mean follow-up period was 9.7 years. Results When compared with the control group at five years, the surgery group had a total plasma cholesterol level 23.3 percent lower (4.71±0.91 vs. 6.14±0.89 mmol per liter [mean ±SD]; P<0.0001), a low-density lipoprotein cholesterol level 37.7 percent lower (2.68±0.78 vs. 4.30±0.89 mmol per liter; P<0.0001), and a high-density lipoprotein cholesterol level 4.3 percent higher (1.08±0.26 vs. 1.04±0.25 mmol per liter; P = 0.02). Overall mortality...
988 citations
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01 Jan 1999
TL;DR: In this article, Solinger challenges the notion that markets necessarily promote rights and legal equality in any direct or linear fashion, and presents an incisive and original study that goes against the grain of much of the current discussion on citizenship.
Abstract: Post-Mao market reforms in China have led to a massive migration of rural peasants toward the cities. Officially denied residency in the cities, the over 80 million members of this "floating population" provide labor for the economic boom in urban areas but are largely denied government benefits that city residents receive. In an incisive and original study that goes against the grain of much of the current discussion on citizenship, Dorothy J. Solinger challenges the notion that markets necessarily promote rights and legal equality in any direct or linear fashion.
987 citations
Authors
Showing all 73925 results
Name | H-index | Papers | Citations |
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Eric S. Lander | 301 | 826 | 525976 |
Trevor W. Robbins | 231 | 1137 | 164437 |
Edward Witten | 202 | 602 | 204199 |
Irving L. Weissman | 201 | 1141 | 172504 |
John C. Morris | 183 | 1441 | 168413 |
Paul M. Thompson | 183 | 2271 | 146736 |
Terrie E. Moffitt | 182 | 594 | 150609 |
John R. Yates | 177 | 1036 | 129029 |
Michael I. Jordan | 176 | 1016 | 216204 |
Russel J. Reiter | 169 | 1646 | 121010 |
George P. Chrousos | 169 | 1612 | 120752 |
Jiawei Han | 168 | 1233 | 143427 |
Zena Werb | 168 | 473 | 122629 |
Douglas F. Easton | 165 | 844 | 113809 |
Bruce L. Miller | 163 | 1153 | 115975 |