University of Udine

About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.

Locally advanced breast cancer: comparison of mammography, sonography and MR imaging in evaluation of residual disease in women receiving neoadjuvant chemotherapy

Abstract: The accuracy of mammography, sonography and magnetic resonance imaging (MRI) in identifying residual disease after neoadjuvant chemotherapy is evaluated and imaging findings are correlated with pathologic findings. Fifteen patients enrolled in an experimental protocol of preoperative neoadjuvant chemotherapy underwent clinical examination, mammography, sonography and dynamic MRI, performed in this order, before and respectively after 2 and 4 cycles of neoadjuvant chemotherapy. Four radiologists, two for mammography, one for sonography and one for MR, examined the images, blinded to the results of the other examinations. All patients underwent radical or conservative surgery, and imaging findings were compared with pathologic findings. MRI identified 2/15 (13.3.%) clinically complete response (CR), 9/15 (60%) partial response (PR), 3/15 (20%) stable disease (SD) and 1/15 (6.7%) progressive disease. Mammography identified 1/15 (6.7%) clinically CR, 8/15 (53.3%) PR and 4/15 (27%) SD, and was not able to evaluate the disease in 2/15 (13%) cases. Sonography presented the same results as MRI. Therefore, MRI and sonography compared to mammography correctly identified residual disease in 100 vs. 86%. MRI resulted in two false-negative results because of the presence of microfoci of in situ ductal carcinoma (DCIS) and invasive lobular carcinoma (LCI). MRI was superior to mammography in cases of multifocal or multicentric disease (83 vs. 33%). Sonography performed after MRI improves the accuracy in evaluation of uncertain foci of multifocal disease seen on MR images with an increase of diagnostic accuracy from 73 to 84.5%. MRI assesses response to neoadjuvant chemotherapy better than traditional methods of physical examination and mammography.

Tuning and test of fragmentation models based on identified particles and precision event shape data

Abstract: Event shape and charged particle inclusive distributions are measured using 750000 decays of the Z to hadrons from the DELPHI detector at LEP. These precise data allow a decisive confrontation with models of the hadronization process. Improved tunings of the JETSET, ARIADNE and HERWIG parton shower models and the JETSET matrix element model are obtained by fitting the models to these DELPHI data as well as to identified particle distributions from all LEP experiments. The description of the data distributions by the models is critically reviewed with special importance attributed to identified particles.

Computational Thinking in K-9 Education

Abstract: In this report we consider the current status of the coverage of computer science in education at the lowest levels of education in multiple countries. Our focus is on computational thinking (CT), a term meant to encompass a set of concepts and thought processes that aid in formulating problems and their solutions in different fields in a way that could involve computers [130].The main goal of this report is to help teachers, those involved in teacher education, and decision makers to make informed decisions about how and when CT can be included in their local institutions. We begin by defining CT and then discuss the current state of CT in K-9 education in multiple countries in Europe as well as the United States. Since many students are exposed to CT outside of school, we also discuss the current state of informal educational initiatives in the same set of countries.An important contribution of the report is a survey distributed to K-9 teachers, aiming at revealing to what extent different aspects of CT are already part of teachers' classroom practice and how this is done. The survey data suggest that some teachers are already involved in activities that have strong potential for introducing some aspects of CT. In addition to the examples given by teachers participating in the survey, we present some additional sample activities and lesson plans for working with aspects of CT in different subjects. We also discuss ways in which teacher training can be coordinated as well as the issue of repositories. We conclude with future directions for research in CT at school.

Identification of a Novel RNA Virus Lethal to Tilapia

Abstract: Tilapines are important for the sustainability of ecological systems and serve as the second most important group of farmed fish worldwide. Significant mortality of wild and cultured tilapia has been observed recently in Israel. The etiological agent of this disease, a novel RNA virus, is described here, and procedures allowing its isolation and detection are revealed. The virus, denominated tilapia lake virus (TiLV), was propagated in primary tilapia brain cells or in an E-11 cell line, and it induced a cytopathic effect at 5 to 10 days postinfection. Electron microscopy revealed enveloped icosahedral particles of 55 to 75 nm. Low-passage TiLV, injected intraperitoneally in tilapia, induced a disease resembling the natural disease, which typically presents with lethargy, ocular alterations, and skin erosions, with >80% mortality. Histological changes included congestion of the internal organs (kidneys and brain) with foci of gliosis and perivascular cuffing of lymphocytes in the brain cortex; ocular inflammation included endophthalmitis and cataractous changes of the lens. The cohabitation of healthy and diseased fish demonstrated that the disease is contagious and that mortalities (80 to 100%) occur within a few days. Fish surviving the initial mortality were immune to further TiLV infections, suggesting the mounting of a protective immune response. Screening cDNA libraries identified a TiLV-specific sequence, allowing the design of a PCR-based diagnostic test. This test enables the specific identification of TiLV in tilapines and should help control the spread of this virus worldwide.