Showing papers by "University of Udine published in 2018"

Pd Metal Catalysts for Cross-Couplings and Related Reactions in the 21st Century: A Critical Review

Abstract: Cross-couplings and related reactions are a class of highly efficient synthetic protocols that are generally promoted by molecular Pd species as catalysts. However, catalysts based on more or less highly dispersed Pd metal have been also employed for this purpose, and their use, which was largely limited to the Heck reaction until the turn of the century, has been extended in recent years to most reactions of this class. This review provides a critical overview on these recent applications of Pd metal catalysts. Particular attention is devoted to the discussion of the mechanistic pathways that have been proposed to explain the catalytic role of Pd metal. Furthermore, the most outstanding Pd metal based catalytic systems that have emerged are illustrated, together with the development of novel approaches to boost the reactivity of Pd metal. A section summarizing the current industrial applications of Pd metal catalyzed reactions of this kind concludes the review.

Predicting Human Eye Fixations via an LSTM-based Saliency Attentive Model.

Abstract: Data-driven saliency has recently gained a lot of attention thanks to the use of convolutional neural networks for predicting gaze fixations. In this paper, we go beyond standard approaches to saliency prediction, in which gaze maps are computed with a feed-forward network, and present a novel model which can predict accurate saliency maps by incorporating neural attentive mechanisms. The core of our solution is a convolutional long short-term memory that focuses on the most salient regions of the input image to iteratively refine the predicted saliency map. In addition, to tackle the center bias typical of human eye fixations, our model can learn a set of prior maps generated with Gaussian functions. We show, through an extensive evaluation, that the proposed architecture outperforms the current state-of-the-art on public saliency prediction datasets. We further study the contribution of each key component to demonstrate their robustness on different scenarios.

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance A Randomized Clinical Trial

Abstract: Importance Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective “carbapenem-sparing” option to treat extended-spectrum β-lactamase producers. Objectives To determine whether definitive therapy with piperacillin-tazobactam is noninferior to meropenem (a carbapenem) in patients with bloodstream infection caused by ceftriaxone-nonsusceptible E coli or K pneumoniae . Design, Setting, and Participants Noninferiority, parallel group, randomized clinical trial included hospitalized patients enrolled from 26 sites in 9 countries from February 2014 to July 2017. Adult patients were eligible if they had at least 1 positive blood culture with E coli or Klebsiella spp testing nonsusceptible to ceftriaxone but susceptible to piperacillin-tazobactam. Of 1646 patients screened, 391 were included in the study. Interventions Patients were randomly assigned 1:1 to intravenous piperacillin-tazobactam, 4.5 g, every 6 hours (n = 188 participants) or meropenem, 1 g, every 8 hours (n = 191 participants) for a minimum of 4 days, up to a maximum of 14 days, with the total duration determined by the treating clinician. Main Outcomes and Measures The primary outcome was all-cause mortality at 30 days after randomization. A noninferiority margin of 5% was used. Results Among 379 patients (mean age, 66.5 years; 47.8% women) who were randomized appropriately, received at least 1 dose of study drug, and were included in the primary analysis population, 378 (99.7%) completed the trial and were assessed for the primary outcome. A total of 23 of 187 patients (12.3%) randomized to piperacillin-tazobactam met the primary outcome of mortality at 30 days compared with 7 of 191 (3.7%) randomized to meropenem (risk difference, 8.6% [1-sided 97.5% CI, −∞ to 14.5%]; P = .90 for noninferiority). Effects were consistent in an analysis of the per-protocol population. Nonfatal serious adverse events occurred in 5 of 188 patients (2.7%) in the piperacillin-tazobactam group and 3 of 191 (1.6%) in the meropenem group. Conclusions and relevance Among patients with E coli or K pneumoniae bloodstream infection and ceftriaxone resistance, definitive treatment with piperacillin-tazobactam compared with meropenem did not result in a noninferior 30-day mortality. These findings do not support use of piperacillin-tazobactam in this setting. Trial Registration anzctr.org.au Identifiers:ACTRN12613000532707andACTRN12615000403538and ClinicalTrials.gov Identifier:NCT02176122

How to manage Pseudomonas aeruginosa infections.

Abstract: Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired infections, especially in critically ill and immunocompromised patients. The major problem leading to high mortality lies in the appearance of drug-resistant strains. Therefore, a vast number of approaches to develop novel anti-infectives is currently pursued. Diverse strategies range from killing (new antibiotics) to disarming (antivirulence) the pathogen. In this review, selected aspects of P. aeruginosa antimicrobial resistance and infection management will be addressed. Many studies have been performed to evaluate the risk factors for resistance and the potential consequences on mortality and attributable mortality. The review also looks at the mechanisms associated with resistance - P. aeruginosa is a pathogen presenting a large genome, and it can develop a large number of factors associated with antibiotic resistance involving almost all classes of antibiotics. Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa treatment. Limitations of current therapies, the potential for alternative drugs and new therapeutic options are also discussed.

Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Abstract: Background In the Suppression of Ovarian Function Trial (SOFT) and the Tamoxifen and Exemestane Trial (TEXT), the 5-year rates of recurrence of breast cancer were significantly lower among premenopausal women who received the aromatase inhibitor exemestane plus ovarian suppression than among those who received tamoxifen plus ovarian suppression. The addition of ovarian suppression to tamoxifen did not result in significantly lower recurrence rates than those with tamoxifen alone. Here, we report the updated results from the two trials. Methods Premenopausal women were randomly assigned to receive 5 years of tamoxifen, tamoxifen plus ovarian suppression, or exemestane plus ovarian suppression in SOFT and to receive tamoxifen plus ovarian suppression or exemestane plus ovarian suppression in TEXT. Randomization was stratified according to the receipt of chemotherapy. Results In SOFT, the 8-year disease-free survival rate was 78.9% with tamoxifen alone, 83.2% with tamoxifen plus ovarian suppression,...

Search for dark matter and other new phenomena in events with an energetic jet and large missing transverse momentum using the ATLAS detector

Abstract: Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses proton-proton collision data corresponding to an integrated luminosity of 36.1 fb−1 at a centre-of-mass energy of 13 TeV collected in 2015 and 2016 with the ATLAS detector at the Large Hadron Collider. Events are required to have at least one jet with a transverse momentum above 250 GeV and no leptons (e or μ). Several signal regions are considered with increasing requirements on the missing transverse momentum above 250 GeV. Good agreement is observed between the number of events in data and Standard Model predictions. The results are translated into exclusion limits in models with pair-produced weakly interacting dark-matter candidates, large extra spatial dimensions, and supersymmetric particles in several compressed scenarios.

Production and integration of the ATLAS Insertable B-Layer

Abstract: During the shutdown of the CERN Large Hadron Collider in 2013-2014, an additional pixel layer was installed between the existing Pixel detector of the ATLAS experiment and a new, smaller radius beam pipe. The motivation for this new pixel layer, the Insertable B-Layer (IBL), was to maintain or improve the robustness and performance of the ATLAS tracking system, given the higher instantaneous and integrated luminosities realised following the shutdown. Because of the extreme radiation and collision rate environment, several new radiation-tolerant sensor and electronic technologies were utilised for this layer. This paper reports on the IBL construction and integration prior to its operation in the ATLAS detector.

Effect and Safety of Meropenem–Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial

Abstract: Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) infections are limited and CRE infections remain associated with high clinical failure and mortality rates, particularly in vulnerable patient populations. A Phase 3, multinational, open-label, randomized controlled trial (TANGO II) was conducted from 2014 to 2017 to evaluate the efficacy/safety of meropenem–vaborbactam monotherapy versus best available therapy (BAT) for CRE. A total of 77 patients with confirmed/suspected CRE infection (bacteremia, hospital-acquired/ventilator-associated bacterial pneumonia, complicated intra-abdominal infection, complicated urinary tract infection/acute pyelonephritis) were randomized, and 47 with confirmed CRE infection formed the primary analysis population (microbiologic-CRE-modified intent-to-treat, mCRE-MITT). Eligible patients were randomized 2:1 to meropenem–vaborbactam (2 g/2 g over 3 h, q8h for 7–14 days) or BAT (mono/combination therapy with polymyxins, carbapenems, aminoglycosides, tigecycline; or ceftazidime-avibactam alone). Efficacy endpoints included clinical cure, Day-28 all-cause mortality, microbiologic cure, and overall success (clinical cure + microbiologic eradication). Safety endpoints included adverse events (AEs) and laboratory findings. Within the mCRE-MITT population, cure rates were 65.6% (21/32) and 33.3% (5/15) [95% confidence interval (CI) of difference, 3.3% to 61.3%; P = 0.03)] at End of Treatment and 59.4% (19/32) and 26.7% (4/15) (95% CI of difference, 4.6% to 60.8%; P = 0.02) at Test of Cure;.Day-28 all-cause mortality was 15.6% (5/32) and 33.3% (5/15) (95% CI of difference, − 44.7% to 9.3%) for meropenem–vaborbactam versus BAT, respectively. Treatment-related AEs and renal-related AEs were 24.0% (12/50) and 4.0% (2/50) for meropenem–vaborbactam versus 44.0% (11/25) and 24.0% (6/25) for BAT. Exploratory risk–benefit analyses of composite clinical failure or nephrotoxicity favored meropenem–vaborbactam versus BAT (31.3% [10/32] versus 80.0% [12/15]; 95% CI of difference, − 74.6% to − 22.9%; P < 0.001). Monotherapy with meropenem–vaborbactam for CRE infection was associated with increased clinical cure, decreased mortality, and reduced nephrotoxicity compared with BAT. NCT02168946. The Medicines Company.

Graphene-silicon phase modulators with gigahertz bandwidth

Abstract: The modulator is a key component in optical communications. Several graphene-based amplitude modulators have been reported based on electro-absorption. However, graphene phase modulators (GPMs) are necessary for functions such as applying complex modulation formats or making switches or phased arrays. Here, we present a 10 Gb s–1 GPM integrated in a Mach–Zehnder interferometer configuration. This is a compact device based on a graphene-insulator–silicon capacitor, with a phase-shifter length of 300 μm and extinction ratio of 35 dB. The GPM has a modulation efficiency of 0.28 V cm at 1,550 nm. It has 5 GHz electro-optical bandwidth and operates at 10 Gb s–1 with 2 V peak-to-peak driving voltage in a push–pull configuration for binary transmission of a non-return-to-zero data stream over 50 km of single-mode fibre. This device is the key building block for graphene-based integrated photonics, enabling compact and energy-efficient hybrid graphene–silicon modulators for telecom, datacom and other applications. A 10 Gb s–1 phase modulator based on a graphene-on-silicon Mach–Zehnder interferometer (MZI) is reported. The compact device has a phase-shifter length of only 300 μm and provides modulation of light at 1,550 nm with a 35 dB extinction ratio.

Effects of Different Types of Virtual Reality Display on Presence and Learning in a Safety Training Scenario

Abstract: The increasing availability of head-mounted displays (HMDs) for home use motivates the study of the possible effects that adopting this new hardware might have on users. Moreover, while the impact of display type has been studied for different kinds of tasks, it has been scarcely explored in procedural training. Our study considered three different types of displays used by participants for training in aviation safety procedures with a serious game. The three displays were respectively representative of: (i) desktop VR (a standard desktop monitor), (ii) many setups for immersive VR used in the literature (an HMD with narrow field of view and a 3-DOF tracker), and (iii) new setups for immersive home VR (an HMD with wide field of view and 6-DOF tracker). We assessed effects on knowledge gain, and different self-reported measures (self-efficacy, engagement, presence). Unlike previous studies of display type that measured effects only immediately after the VR experience, we considered also a longer time span (2 weeks). Results indicated that the display type played a significant role in engagement and presence. The training benefits (increased knowledge and self-efficacy) were instead obtained, and maintained at two weeks, regardless of the display used. The paper discusses the implications of these results.

Performance of missing transverse momentum reconstruction with the ATLAS detector using proton-proton collisions at s√ = 13 TeV

Abstract: The performance of the missing transverse momentum ( ETmiss ) reconstruction with the ATLAS detector is evaluated using data collected in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct ETmiss , fully calibrated electrons, muons, photons, hadronically decaying τ-leptons , and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects. Possible double counting of contributions from reconstructed charged-particle tracks from the inner detector, energy deposits in the calorimeter, and reconstructed muons from the muon spectrometer is avoided by applying a signal ambiguity resolution procedure which rejects already used signals when combining the various ETmiss contributions. The individual terms as well as the overall reconstructed ETmiss are evaluated with various performance metrics for scale (linearity), resolution, and sensitivity to the data-taking conditions. The method developed to determine the systematic uncertainties of the ETmiss scale and resolution is discussed. Results are shown based on the full 2015 data sample corresponding to an integrated luminosity of 3.2fb-1 .

Search for Higgs boson pair production in the γ γ bb¯ final state with 13 TeV pp collision data collected by the ATLAS experiment

Abstract: A search is performed for resonant and non-resonant Higgs boson pair production in the $ \upgamma \upgamma b\overline{b} $ final state. The data set used corresponds to an integrated luminosity of 36.1 fb$^{−1}$ of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess relative to the Standard Model expectation is observed. The observed limit on the non-resonant Higgs boson pair cross-section is 0.73 pb at 95% confidence level. This observed limit is equivalent to 22 times the predicted Standard Model cross-section. The Higgs boson self-coupling (κ$_{λ}$ = λ$_{HHH}$/λ$_{HHH}^{SM}$ ) is constrained at 95% confidence level to −8.2 < κ$_{λ}$ < 13.2. For resonant Higgs boson pair production through $ X\to HH\to \upgamma \upgamma b\overline{b} $ , the limit is presented, using the narrow-width approximation, as a function of m$_{X}$ in the range 260 GeV < m$_{X}$ < 1000 GeV. The observed limits range from 1.1 pb to 0.12 pb over this mass range.

Measurement of the W-boson mass in pp collisions at s=7TeV with the ATLAS detector.

Abstract: A measurement of the mass of the $W$ boson is presented based on proton-proton collision data recorded in 2011 at a centre-of-mass energy of 7 TeV with the ATLAS detector at the LHC, and corresponding to 4.6 fb$^{-1}$ of integrated luminosity. The selected data sample consists of $7.8 \times 10^6$ candidates in the $W\rightarrow \mu u$ channel and $5.9 \times 10^6$ candidates in the $W\rightarrow e u$ channel. The $W$-boson mass is obtained from template fits to the reconstructed distributions of the charged lepton transverse momentum and of the $W$ boson transverse mass in the electron and muon decay channels, yielding \begin{eqnarray} m_W &=& 80370 \pm 7 \, (\textrm{stat.}) \pm 11 \, (\textrm{exp. syst.}) \pm 14 \, (\textrm{mod. syst.}) \, \textrm{MeV} &=& 80370 \pm 19 \, \textrm{MeV}, \end{eqnarray} where the first uncertainty is statistical, the second corresponds to the experimental systematic uncertainty, and the third to the physics-modelling systematic uncertainty. A measurement of the mass difference between the $W^+$ and $W^-$ bosons yields $m_{W^+}-m_{W^-} = -29 \pm 28$ MeV.

Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: Results of two phase 3, randomized, placebo-controlled trials.

Abstract: Spleen tyrosine kinase (Syk) signaling is central to phagocytosis-based, antibody-mediated platelet destruction in adults with immune thrombocytopenia (ITP). Fostamatinib, an oral Syk inhibitor, produced sustained on-treatment responses in a phase 2 ITP study. In two parallel, phase 3, multicenter, randomized, double-blind, placebo-controlled trials (FIT1 and FIT2), patients with persistent/chronic ITP were randomized 2:1 to fostamatinib (n = 101) or placebo (n = 49) at 100 mg BID for 24 weeks with a dose increase in nonresponders to 150 mg BID after 4 weeks. The primary endpoint was stable response (platelets ≥50 000/μL at ≥4 of 6 biweekly visits, weeks 14-24, without rescue therapy). Baseline median platelet count was 16 000/μL; median duration of ITP was 8.5 years. Stable responses occurred in 18% of patients on fostamatinib vs. 2% on placebo (P = .0003). Overall responses (defined retrospectively as ≥1 platelet count ≥50 000/μL within the first 12 weeks on treatment) occurred in 43% of patients on fostamatinib vs. 14% on placebo (P = .0006). Median time to response was 15 days (on 100 mg bid), and 83% responded within 8 weeks. The most common adverse events were diarrhea (31% on fostamatinib vs. 15% on placebo), hypertension (28% vs. 13%), nausea (19% vs. 8%), dizziness (11% vs. 8%), and ALT increase (11% vs. 0%). Most events were mild or moderate and resolved spontaneously or with medical management (antihypertensive, anti-motility agents). Fostamatinib produced clinically-meaningful responses in ITP patients including those who failed splenectomy, thrombopoietic agents, and/or rituximab. Fostamatinib is a novel ITP treatment option that targets an important mechanism of ITP pathogenesis.

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

Abstract: The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics. Predictions have been expanded to provide new types of annotation on backbone rigidity, secondary structure preference and disordered binding regions. MobiDB 3.0 contains information for the complete UniProt protein set and synchronization has been improved by covering all UniParc sequences. An advanced search function allows the creation of a wide array of custom-made datasets for download and further analysis. A large amount of information and cross-links to more specialized databases are intended to make MobiDB the central resource for the scientific community working on protein intrinsic disorder and mobility.

The Blazar TXS 0506+056 Associated with a High-energy Neutrino: Insights into Extragalactic Jets and Cosmic-Ray Acceleration

Abstract: A neutrino with energy similar to 290 TeV, IceCube-170922A, was detected in coincidence with the BL Lac object TXS. 0506+056 during enhanced gamma-ray activity, with chance coincidence being rejected at similar to 3 sigma level. We monitored the object in the very-high-energy (VHE) band with the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes for similar to 41 hr from 1.3 to 40.4 days after the neutrino detection. Day-timescale variability is clearly resolved. We interpret the quasi-simultaneous neutrino and broadband electromagnetic observations with a novel one-zone lepto-hadronic model, based on interactions of electrons and protons co-accelerated in the jet with external photons originating from a slow-moving plasma sheath surrounding the faster jet spine. We can reproduce the multiwavelength spectra of TXS 0506+056 with neutrino rate and energy compatible with IceCube-170922A, and with plausible values for the jet power of similar to 10(45) - 4 x 10(46) erg s(-1). The steep spectrum observed by MAGIC is concordant with internal gamma gamma absorption above similar to 100 GeV entailed by photohadronic production of a similar to 290 TeV neutrino, corroborating a genuine connection between the multi-messenger signals. In contrast to previous predictions of predominantly hadronic emission from neutrino sources, the gamma-rays can be mostly ascribed to inverse Compton upscattering of external photons by accelerated electrons. The X-ray and VHE bands provide crucial constraints on the emission from both accelerated electrons and protons. We infer that the maximum energy of protons in the jet comoving frame can be in the range similar to 10(14) - 10(18) eV.

Search for electroweak production of supersymmetric particles in final states with two or three leptons at √s=13 TeV with the ATLAS detector

Abstract: A search for the electroweak production of charginos, neutralinos and sleptons decaying into final states involving two or three electrons or muons is presented. The analysis is based on 36.1 fb$^{-1}$ of $\sqrt{s}=13$ TeV proton–proton collisions recorded by the ATLAS detector at the Large Hadron Collider. Several scenarios based on simplified models are considered. These include the associated production of the next-to-lightest neutralino and the lightest chargino, followed by their decays into final states with leptons and the lightest neutralino via either sleptons or Standard Model gauge bosons, direct production of chargino pairs, which in turn decay into leptons and the lightest neutralino via intermediate sleptons, and slepton pair production, where each slepton decays directly into the lightest neutralino and a lepton. No significant deviations from the Standard Model expectation are observed and stringent limits at 95% confidence level are placed on the masses of relevant supersymmetric particles in each of these scenarios. For a massless lightest neutralino, masses up to 580 GeV are excluded for the associated production of the next-to-lightest neutralino and the lightest chargino, assuming gauge-boson mediated decays, whereas for slepton-pair production masses up to 500 GeV are excluded assuming three generations of mass-degenerate sleptons.

Combination of the searches for pair-produced vectorlike partners of the third-generation quarks at s =13 TeV with the ATLAS detector

Abstract: A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T -> Zt/Wb/Ht, B -> Zb/Wt/Hb) is performed using 36.1 fb(-1) of pp ...

A Systematic Literature Review on Recent Lean Research: State-of-the-art and Future Directions

Abstract: Lean management (LM) has attracted the interest of scientists and practitioners since 1990, when Womack et al. (Womack, J.P., Jones, D.T. and Roos, D. (1990). The Machine that Changed the World. New York, NY: Rawson Associates) popularized the Japanese manufacturing approach aimed at eliminating waste to improve operational performance and customer satisfaction. Over the years, the lean concept has evolved becoming a managerial paradigm applicable to different sectors and processes with impressive results. This heterogeneity of implementations and settings makes the recent LM literature diverse and fragmented, and an extensive analysis of the latest contributions on this field is lacking. To address this gap, the authors propose a systematic literature review (SLR) of 240 articles published in 25 peer-reviewed academic journals from January 2003 to December 2015. The purpose is to analyse the recent trends in this area and to provide a framework that organizes lean researched issues into mature, intermediate and nascent, based on their position in the research life cycle. Starting from the gaps that the SLR highlights, the authors suggest conducting lean research in the following directions: (a) grounding lean studies on existing managerial theories; (b) addressing service settings such as banking/finance, public sector and education; (c) exploring the role of national culture through cross-country comparisons; (d) defining and conceptualizing ‘lean-x’ processes; (e) understanding the relationships between lean and safety/environmental issues, and (f) unveiling the effects on social outcomes. Finally, the proposed framework helps scholars find issues not sufficiently explored that require theory-building research (to move from nascent to intermediate) or theory-testing research (to move from intermediate to mature).

Search for electroweak production of supersymmetric states in scenarios with compressed mass spectra at s=13 TeV with the ATLAS detector

Abstract: A search for electroweak production of supersymmetric particles in scenarios with compressed mass spectra in final states with two low-momentum leptons and missing transverse momentum is presented. This search uses proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015–2016, corresponding to 36.1 fb − 1 of integrated luminosity at √ s = 13 TeV . Events with same-flavor pairs of electrons or muons with opposite electric charge are selected. The data are found to be consistent with the Standard Model prediction. Results are interpreted using simplified models of R -parity-conserving supersymmetry in which there is a small mass difference between the masses of the produced supersymmetric particles and the lightest neutralino. Exclusion limits at 95% confidence level are set on next-to-lightest neutralino masses of up to 145 GeV for Higgsino production and 175 GeV for wino production, and slepton masses of up to 190 GeV for pair production of sleptons. In the compressed mass regime, the exclusion limits extend down to mass splittings of 2.5 GeV for Higgsino production, 2 GeV for wino production, and 1 GeV for slepton production. The results are also interpreted in the context of a radiatively-driven natural supersymmetry model with nonuniversal Higgs boson masses.

Search for doubly charged Higgs boson production in multi-lepton final states with the ATLAS detector using proton-proton collisions at s=13TeV.

Abstract: A search for doubly charged Higgs bosons with pairs of prompt, isolated, highly energetic leptons with the same electric charge is presented. The search uses a proton–proton collision data sample at a centre-of-mass energy of 13 TeV corresponding to 36.1 $$\text {fb}^{-1}$$ of integrated luminosity recorded in 2015 and 2016 by the ATLAS detector at the LHC. This analysis focuses on the decays $$H^{\pm \pm }\rightarrow e^{\pm }e^{\pm }$$ , $$H^{\pm \pm }\rightarrow e^{\pm }\mu ^{\pm }$$ and $$H^{\pm \pm }\rightarrow \mu ^{\pm }\mu ^{\pm }$$ , fitting the dilepton mass spectra in several exclusive signal regions. No significant evidence of a signal is observed and corresponding limits on the production cross-section and consequently a lower limit on $$m(H^{\pm \pm })$$ are derived at 95% confidence level. With $$\ell ^{\pm }\ell ^{\pm }=e^{\pm }e^{\pm }/\mu ^{\pm }\mu ^{\pm }/e^{\pm }\mu ^{\pm }$$ , the observed lower limit on the mass of a doubly charged Higgs boson only coupling to left-handed leptons varies from 770 to 870 GeV (850 GeV expected) for $$B(H^{\pm \pm }\rightarrow \ell ^{\pm }\ell ^{\pm })=100\%$$ and both the expected and observed mass limits are above 450 GeV for $$B(H^{\pm \pm }\rightarrow \ell ^{\pm }\ell ^{\pm })=10\%$$ and any combination of partial branching ratios.

Graphene-based integrated photonics for next-generation datacom and telecom

Abstract: Graphene is an ideal material for optoelectronic applications. Its photonic properties give several advantages and complementarities over Si photonics. For example, graphene enables both electro-absorption and electro-refraction modulation with an electro-optical index change exceeding 10−3. It can be used for optical add–drop multiplexing with voltage control, eliminating the current dissipation used for the thermal detuning of microresonators, and for thermoelectric-based ultrafast optical detectors that generate a voltage without transimpedance amplifiers. Here, we present our vision for graphene-based integrated photonics. We review graphene-based transceivers and compare them with existing technologies. Strategies for improving power consumption, manufacturability and wafer-scale integration are addressed. We outline a roadmap of the technological requirements to meet the demands of the datacom and telecom markets. We show that graphene-based integrated photonics could enable ultrahigh spatial bandwidth density, low power consumption for board connectivity and connectivity between data centres, access networks and metropolitan, core, regional and long-haul optical communications.

Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes.

Abstract: The predominant mechanism by which adipose mesenchymal stem cells (AMSCs) participate to tissue repair is through a paracrine activity and their communication with the inflammatory microenvironment is essential part of this process. This hypothesis has been strengthened by the recent discovery that stem cells release not only soluble factors but also extracellular vesicles, which elicit similar biological activity to the stem cells themselves. We demonstrated that the treatment with inflammatory cytokines increases the immunosuppressive and anti-inflammatory potential of AMSCs-derived exosomes, which acquire the ability to shift macrophages from M1 to M2 phenotype by shuttling miRNA regulating macrophages polarization. This suggests that the immunomodulatory properties of AMSCs-derived exosomes may be not constitutive, but are instead induced by the inflammatory microenvironment.

Search for charged Higgs bosons decaying via H ± → τ ± ντ in the τ+jets and τ+lepton final states with 36 fb−1 of pp collision data recorded at √s=13 TeV with the ATLAS experiment

Abstract: Charged Higgs bosons produced either in top-quark decays or in association with a top-quark, subsequently decaying via H$^{±}$ → τ$^{±}$ν$_{τ}$, are searched for in 36.1 fb$^{−1}$ of proton-proton collision data at $ \sqrt{s}=13 $ TeV recorded with the ATLAS detector. Depending on whether the top-quark produced together with H$^{±}$ decays hadronically or leptonically, the search targets τ+jets and τ+lepton final states, in both cases with a hadronically decaying τ-lepton. No evidence of a charged Higgs boson is found. For the mass range of $ {m}_{H^{\pm }} $ = 90–2000 GeV, upper limits at the 95% confidence level are set on the production cross-section of the charged Higgs boson times the branching fraction $ \mathrm{\mathcal{B}}\left({H}^{\pm}\to {\tau}^{\pm }{ u}_{\tau}\right) $ in the range 4.2–0.0025 pb. In the mass range 90–160 GeV, assuming the Standard Model cross-section for $ t\overline{t} $ production, this corresponds to upper limits between 0.25% and 0.031% for the branching fraction $ \mathrm{\mathcal{B}}\left(t\to b{H}^{\pm}\right)\times \mathrm{\mathcal{B}}\left({H}^{\pm}\to {\tau}^{\pm }{ u}_{\tau}\right) $ .

Linking organic matter chemistry with soil aggregate stability: Insight from 13C NMR spectroscopy

Abstract: Soil aggregation is considered as a crucial process in agro-system sustainability due to the role in soil physical, chemical and biological dynamics. Here we tested the hypothesis that the initial chemical traits of organic matter (OM) may help to explain the variability of soil aggregation dynamics after organic amendment. We characterized ten OM types (alfalfa litter, biochar, cellulose, glucose, green compost, maize litter, manure compost, meat powder, sawdust, and solid digestate) by 13C-CPMAS NMR and elemental chemical features to investigate the effects of amendment quality on soil aggregation. In a manipulative factorial experiment, dry samples (200 g) of three soil types (S1, S2 and S3) with different texture, high pH (7–9), and similar OM content, were incorporated with 4 g (2% w/w) of dry, 2 mm-grounded OM, incubated in mesocosms for 300 days under controlled temperature (18 ± 2 °C night and 24 ± 2 °C day), and sampled at 4 dates for measuring aggregation index (AI), based on water stability of soil aggregates (WSA). We found that meat powder and alfalfa litter induced a rapid initial increase of AI, exceeding that of the controls by one to two orders of magnitude, likely acting as a C source for microbes. Biochar incorporation in soil barely affected AI, with intermediate effects with other OM types. Considering C bond types corresponding to OM 13C-CPMAS NMR spectral regions, carbonyl C was only correlated to early AI, possibly due to overlapping signals of amide structures; O-alkyl C and di-O-alkyl C (carbohydrate fraction) were positively associated to AI, indicating a promoting effect on soil structure, while aromatic C fractions showed an opposite pattern, possibly related to aggregate protection by coatings associated to water repellency, or to direct aggregate internal binding. This study demonstrates that OM chemical quality plays an important role in soil aggregation process, with the molecular composition defined by 13C-CPMAS NMR spectroscopy being more predictive of aggregation dynamics compared to classical elemental features. As such, this study provides a significant novel contribution to clarify the relationships between OM chemistry and soil aggregation.

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors.

Abstract: Cyclin-dependent kinases (CDK) 4/6 inhibitors, namely abemaciclib, palbociclib, and ribociclib, interfere with cell cycle progression, induce cell senescence and might promote cancer cell disruption by a cytotoxic T cells-mediated effect. Phase III randomized clinical trials have proven that CDK4/6 inhibitors (CDK4/6i) in combination with several endocrine agents improve treatment efficacy over endocrine agents alone for hormone receptor positive (HR+) HER2 negative (HER2-) metastatic breast cancer (MBC). Based on such results, these combinations have been approved for clinical use. Preclinical studies in cell cultures and mouse models proved that CDK4/6i are active against a broad spectrum of solid tumors other than breast cancer, including liposarcoma, rhabdomyosarcoma, non-small cell lung cancer, glioblastoma multiforme, esophageal cancer, and melanoma. The role of CDK4/6i in monotherapy in several solid tumors is currently under evaluation in phase I, II, and III trials. Nowadays, abemaciclib is the only of the three inhibitors that has received approval as single agent therapy for pretreated HR+ HER2- MBC. Here we review biological, preclinical and clinical data on the role of CDK4/6 inhibitors as single agents in advanced solid tumors.

Wide-Slice Residual Networks for Food Recognition

Abstract: Image-based food recognition pose new challenges for mainstream computer vision algorithms. Recent works in the field focused either on hand-crafted representations or on learning these by exploiting deep neural networks (DNN). Despite the success of DNN-based works, these exploit off-the-shelf deep architectures which are not cast to the specific food classification problem. We believe that better results can be obtained if the architecture is defined with respect to an analysis of the food composition. Following such an intuition, this work introduces a new deep scheme that is designed to handle the food structure. In particular, we focus on the vertical food traits that are common to a large number of categories (i.e., 15% of the whole data in current datasets). Towards the final objective, we first introduce a slice convolution block to capture such specific information. Then, we leverage on the recent success of deep residual blocks and combine those with the sliced convolution to produce the classification score. Extensive evaluations on three benchmark datasets demonstrated that our solution has better performance than existing approaches (e.g., a top–1 accuracy of 90.27% on the Food-101 dataset).

Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb-1 of s =13 TeV pp collision data with the ATLAS detector

Abstract: A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented ...