University of Udine

About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.

Surgical margins in head and neck cancer: A contemporary review

Abstract: Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.

Describing the macroscopic world: Closing the circle within the dynamical reduction program

Abstract: With reference to recently proposed theoretical models accounting for reduction in terms of a unified dynamics governing all physical processes, we analyze the problem of working out a worldview accommodating our knowledge about natural phenomena. We stress the relevant conceptual differences between the considered models and standard quantum mechanics. In spite of the fact that both theories describe systems within a genuine Hilbert space framework, the peculiar features of the spontaneous reduction models limit drastically the states which are dynamically stable. This fact by itself allows one to work out an interpretation of the formalism which makes it possible to give a satisfactory description of the world in terms of the values taken by an appropriately defined mass density function in ordinary configuration space. A topology based on this function and which is radically different from the one characterizing the Hilbert space is introduced, and in terms of it the idea of similarity of macroscopic situations is precisely defined. Finally, the formalism and the interpretation are shown to yield a natural criterion for establishing the psychophysical parallelism. The conclusion is that, within the considered theories and at the nonrelativistic level, one can satisfy all sensible requirements for a completely satisfactory macro-objective description of reality.

The resistance of Varroa jacobsoni Oud. to acaricides

Abstract: A serious problem in the control of the mite Varroa jacobsoni Oudemans is the selection of acaricide-resistant strains. Increased tolerance of this mite to several active substances (acrinathrin, amitraz, bromopropylate, chlordimeform, coumaphos, flumethrin, fluvalinate) was determined with laboratory assays or presumed as the most likely explanation of decreased field efficacy. Resistance to fluvalinate in Italy and later in other countries caused heavy damage to beekeeping. Early detec- tion of the presence of resistant Varroa mites was crucial to reduce losses. Regarding resistance management tactics, 'moderation tactics' seem to be more suitable than 'high dose tactics' to delay the selection of resistant Varroa strains. © Inra/DIB/AGIB/Elsevier, Paris

Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.

Abstract: The solution structure and stability of N-terminally truncated beta2-microglobulin (deltaN6beta2-m), the major modification in ex vivo fibrils, have been investigated by a variety of biophysical techniques. The results show that deltaN6beta2-m has a free energy of stabilization that is reduced by 2.5 kcal/mol compared to the intact protein. Hydrogen exchange of a mixture of the truncated and full-length proteins at microM concentrations at pH 6.5 monitored by electrospray mass spectrometry reveals that deltaN6beta2-m is significantly less protected than its wild-type counterpart. Analysis of deltaN6beta2-m by NMR shows that this loss of protection occurs in beta strands I, III, and part of II. At mM concentration gel filtration analysis shows that deltaN6beta2-m forms a series of oligomers, including trimers and tetramers, and NMR analysis indicates that strand V is involved in intermolecular interactions that stabilize this association. The truncated species of beta2-microglobulin was found to have a higher tendency to self-associate than the intact molecule, and unlike wild-type protein, is able to form amyloid fibrils at physiological pH. Limited proteolysis experiments and analysis by mass spectrometry support the conformational modifications identified by NMR and suggest that deltaN6beta2-m could be a key intermediate of a proteolytic pathway of beta2-microglobulin. Overall, the data suggest that removal of the six residues from the N-terminus of beta2-microglobulin has a major effect on the stability of the overall fold. Part of the tertiary structure is preserved substantially by the disulfide bridge between Cys25 and Cys80, but the pairing between beta-strands far removed from this constrain is greatly perturbed.