Institution
University of Udine
Education•Udine, Italy•
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.
Papers published on a yearly basis
Papers
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TL;DR: The results confirm the conclusion that this strategy is a powerful tool for rapid and accurate identification of bacterial species and that mass spectrometric methodologies could play an essential role in polyphasic approaches to the identification of pathogenic bacteria.
Abstract: A methodology based on matrix-assisted laser desorption ionization-time of flight mass spectrometry of intact bacterial cells was used for rapid discrimination of 24 bacterial species, and detailed analyses to identify Escherichia coli O157:H7 were carried out. Highly specific mass spectrometric profiles of pathogenic and nonpathogenic bacteria that are well-known major food contaminants were obtained, uploaded in a specific database, and made available on the Web. In order to standardize the analytical protocol, several experimental, sample preparation, and mass spectrometry parameters that can affect the reproducibility and accuracy of data were evaluated. Our results confirm the conclusion that this strategy is a powerful tool for rapid and accurate identification of bacterial species and that mass spectrometric methodologies could play an essential role in polyphasic approaches to the identification of pathogenic bacteria.
142 citations
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University of Gothenburg1, Foothills Medical Centre2, University of the Algarve3, Charles University in Prague4, University of Texas Southwestern Medical Center5, University of Arkansas for Medical Sciences6, Kobe University7, University of Udine8, University of Calgary9, Katholieke Universiteit Leuven10
TL;DR: The clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics are described, finding them promising as prognostic biomarkers and targets of therapy.
Abstract: Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion. Hyalinizing clear cell carcinoma is a low-grade tumor with infrequent nodal and distant metastasis, recently shown to harbor an EWSR1-ATF1 gene fusion. The CRTC1-MAML2 fusion gene resulting from a t(11;19)(q21;p13) translocation, is now known to be a feature of both low-grade and high-grade mucoepidermoid carcinomas associated with improved survival. A t(6;9)(q22-23;p23-34) translocation resulting in a MYB-NFIB gene fusion has been identified in the majority of adenoid cystic carcinomas. Polymorphous (low-grade) adenocarcinoma and cribriform adenocarcinoma of (minor) salivary gland origin are related entities with partly differing clinicopathologic and genomic profiles; they are the subject of an ongoing taxonomic debate. Polymorphous (low-grade) adenocarcinomas are characterized by hot spot point E710D mutations in the PRKD1 gene, whereas cribriform adenocarcinoma of (minor) salivary glands origin are characterized by translocations involving the PRKD1-3 genes. Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma with morphologic and molecular features akin to invasive ductal carcinoma of the breast, including HER2 gene amplification, mutations of TP53, PIK3CA, and HRAS and loss or mutation of PTEN. Notably, a recurrent NCOA4-RET fusion has also been found in SDC. A subset of SDC with apocrine morphology is associated with overexpression of androgen receptors. As these genetic aberrations are recurrent they serve as powerful diagnostic tools in salivary gland tumor diagnosis, and therefore also in refinement of salivary gland cancer classification. Moreover, they are promising as prognostic biomarkers and targets of therapy.
142 citations
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TL;DR: In this paper, an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon is presented, using 1.04 fb(-1) of proton-proton collision data at root s =7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011.
Abstract: We present an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon, using 1.04 fb(-1) of proton-proton collision data at root s =7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011. The analysis is carried out in four distinct signal regions with either three or four jets and variations on the (missing) transverse momentum cuts, resulting in optimized limits for various supersymmetry models. No excess above the standard model background expectation is observed. Limits are set on the visible cross section of new physics within the kinematic requirements of the search. The results are interpreted as limits on the parameters of the minimal supergravity framework, limits on cross sections of simplified models with specific squark and gluino decay modes, and limits on parameters of a model with bilinear R-parity violation.
142 citations
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TL;DR: It is shown that IL-15 can stimulate monocytes to produce chemokines that cause inflammatory cell accumulation and may play a pivotal role in the regulation of the leukocyte infiltrate.
142 citations
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15 Sep 2015
TL;DR: A platform-based design methodology that uses contracts to specify and abstract the components of a cyber-physical system (CPS), and provide formal support to the entire CPS design flow is introduced.
Abstract: We introduce a platform-based design methodology that uses contracts to specify and abstract the components of a cyber-physical system (CPS), and provide formal support to the entire CPS design flow. The design is carried out as a sequence of refinement steps from a high-level specification to an implementation built out of a library of components at the lower level. We review formalisms and tools that can be used to specify, analyze, or synthesize the design at different levels of abstraction. For each level, we highlight how the contract operations can be concretely computed as well as the research challenges that should be faced to fully implement them. We illustrate our approach on the design of embedded controllers for aircraft electric power distribution systems.
142 citations
Authors
Showing all 6857 results
Name | H-index | Papers | Citations |
---|---|---|---|
M.-Marsel Mesulam | 150 | 558 | 90772 |
Francesco Longo | 142 | 745 | 89859 |
Georges Aad | 135 | 1121 | 88811 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
G. Della Ricca | 133 | 1598 | 92678 |
Marina Cobal | 132 | 1078 | 85437 |
Fernando Barreiro | 130 | 1082 | 83413 |
Saverio D'Auria | 129 | 1142 | 83684 |
Jean-Francois Grivaz | 128 | 1322 | 97758 |
Evgeny Starchenko | 128 | 864 | 75913 |
Muhammad Alhroob | 127 | 880 | 71982 |
Michele Pinamonti | 126 | 846 | 69328 |
Reisaburo Tanaka | 126 | 967 | 69849 |
Kerim Suruliz | 126 | 795 | 69456 |
Kate Shaw | 125 | 841 | 70087 |