University of Udine

About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.

Fermi large area telescope search for photon lines from 30 to 200 GeV and dark matter implications.

Abstract: Dark matter (DM) particle annihilation or decay can produce monochromatic gamma rays readily distinguishable from astrophysical sources. gamma- ray line limits from 30 to 200 GeV obtained from 11 m ...

α1 Acid Glycoprotein Binds to Imatinib (STI571) and Substantially Alters Its Pharmacokinetics in Chronic Myeloid Leukemia Patients

Abstract: Purpose: Imatinib (Glivec) is a potent inhibitor of bcr/abl, an oncogenic fusion protein that causes chronic myelogenous leukemia (CML). α1 acid glycoprotein (AGP) binds to imatinib with high affinity and inhibits imatinib activity in vitro and in vivo in an animal model. A pharmacokinetics analysis of imatinib was undertaken in CML patients. Experimental Design: Imatinib plasma concentrations were measured in 19 CML patients treated with imatinib (400 or 600 mg/day). Five patients received a concomitant short-term course of clindamycin (CLI). Results: A positive correlation between AGP and imatinib plasma levels was observed. CLI administration decreased imatinib plasma concentrations, evaluated as area under the curve ( AUC ) and peak concentrations ( C max ). The effects of a bolus of CLI was studied in three patients on imatinib 23 h after the last imatinib dose. Within 5–10 min in three of three cases, CLI caused a decrease in imatinib plasma concentrations of 2.6-, 2.7-, and 4.7-fold, respectively. In vitro experiments using fresh blasts from CML patients showed that AGP, at concentrations observed in the patients, decreased imatinib intracellular concentrations up to 10 times and blocked imatinib activity. The incubation with CLI restored imatinib intracellular concentrations and biological activity. Conclusion: AGP exerts significant effects of the pharmacokinetics, plasma concentrations, and intracellular distribution of imatinib in CML patients; these data indicate that plasma imatinib levels represent unreliable indicators of the cellular concentrations of this molecule.

Tabu Search Techniques for Examination Timetabling

Abstract: The EXAMINATION TIMETABLING problem regards the scheduling for the exams of a set of universitycourses, avoiding the overlapping of exams having students in common, fairlyspreading the exams for the students, and satisfying room capacity constraints. We present a familyof solution algorithms for a set of variants of the EXAMINATION TIMETABLING problem. The algorithms are based on tabu search, and theyimp ort several features from the research on the GRAPH COLOURING problem. Our algorithms are tested on both public benchmarks and random instances, and theyare compared with previous results in the literature. The comparison shows that the presented algorithms performs as well as constructive methods and memetic algorithms, and onlya decomposition based approach outperforms them in most cases.