Showing papers in "Bone in 2019"
••
TL;DR: Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism.
123 citations
••
TL;DR: Findings point to targeting senescence as a transformational strategy to extend healthspan, therefore providing strong rationale for identifying and optimizing senotherapeutics to alleviate multiple chronic diseases of aging, including osteoporosis.
110 citations
••
TL;DR: A general overview of the existing GWAS studies on osteoporosis traits and fracture risk is provided to provide an overview of several of the pathways identified by the GWAS efforts correspond to pathways that are currently targeted for the treatment of osteopOrosis.
91 citations
••
TL;DR: The roles of any of these factors in skeletal fragility are difficult to assess clinically as there is no easy or economical way to evaluate them, but a picture of fragility in the aging skeleton is incomplete without them.
86 citations
••
TL;DR: This review focuses on mechanisms that contribute to the loss of muscle force generation when estrogen is low in females, and conversely the maintenance of strength by estrogen, and how these mechanisms affect quality and the design of therapeutic strategies to minimize skeletal muscle pathologies.
83 citations
••
TL;DR: An exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development is given.
74 citations
••
TL;DR: It is suggested that in adults and adolescents with pediatric-onset HPP, treatment with asfotase alfa is associated with normalization of circulating TNSALP substrate levels and improved functional abilities.
73 citations
••
TL;DR: It is concluded that a bisphosphonate, when combined with resistive exercise, enhances the preservation of bone mass because of the added suppression of bone resorption in trabecular bone compartment not evident with ARED alone.
72 citations
••
TL;DR: The sirtuin family of NAD+-dependent protein deacetylases promote longevity and counteracts age-related diseases as mentioned in this paper, and have been shown to play a major role in the adaptation of cells to a variety of stressors such as oxidative stress and growth factor deprivation.
72 citations
••
TL;DR: A systematic review and meta-analysis provides evidence of efficacy of teriparatide in reducing hip fractures by 56% in patients with osteoporosis.
68 citations
••
TL;DR: Exercise induced changes in microbiota composition could represent a novel mechanism that contributes to exercise induced benefits to bone health.
••
TL;DR: It is shown that over-expression of the miR-181a/b-1 cluster enhanced osteogenesis and that cellular pathways associated with protein synthesis and mitochondrial metabolism were significantly up-regulated, and a potential mechanism causing these metabolic changes was deciphered.
••
TL;DR: Establishing a better understanding of fat storage in bone marrow cells, as well as the osteoblast-adipocyte relationship within the bone marrow niche is necessary to understand the mechanisms underlying disease- and aging-related marrow fat storage and may lead to the development of new therapeutic targets for "fatty bone" and osteoporosis.
••
TL;DR: Clinical studies of marrow fat and its relationship with bone are focused on and a few studies suggest that a lower proportion of unsaturated lipids in vertebral BMF may be associated with reduced BMD and greater prevalence of fracture.
••
TL;DR: The results indicate that the IL-6/STAT3/JMJD2B pathway regulates hVSMCs differentiation into osteoblast-like cells, which suggest its pathogenic role in vascular calcification associated with chronic inflammation.
••
TL;DR: Data from a retrospective chart review of pediatric patients treated for osteoporosis with intravenous pamidronate (PAM) or zoledronic acid (ZA) at Cincinnati Children's Hospital Medical Center from 2010 to 2017 suggest that IV BP can be safely used in Pediatrics with varying presentations of compromised bone health.
••
TL;DR: A more complete understanding of the structure and function of the osteocyte network, its lacunocanalicular system, and the degenerative changes that occur with aging should lead to advances in the understanding of age related bone loss and potentially lead to improved therapies.
••
TL;DR: The present review summarizes the current knowledge about the evolution, development, structure, mineralization, and biomechanics of antlers and how their formation is affected by environmental factors like nutrition.
••
TL;DR: A retrospective analysis of the most recent 261 Chinese patients with XLH evaluated at Peking Union Medical College Hospital provided a comprehensive characterization of the largest cohort of patients reported to date from China, which will help in evaluating the applicability of emerging therapies for this disease in this ethnic group.
••
TL;DR: The genetic determinants of circulating vitamin D levels are reviewed by focusing on new findings from GWAS and WGS, as well as results from Mendelian randomization analyses conducted so far for vitamin D with various traits and diseases.
••
TL;DR: There is a strong rationale supporting the use of zebrafish for human skeletal genomic studies, due to their amenability to rapid genetic approaches, as well as the large number of conserved genetic and phenotypic features.
••
TL;DR: Poor glycemic control and long exposure to the disease are independent diabetes-related risk factors for multiple bone fractures in T1D.
••
TL;DR: The reliability of the Rickets Severity Score is shown, and it is demonstrated that higher RSS values are associated with greater biochemical, clinical, and functional impairments in children with XLH.
••
TL;DR: Findings show that the ACE2/Ang-(1-7)/MasR is an active player in alveolar bone remodeling in osteoblasts and osteoclasts in vitro and in vivo.
••
TL;DR: It is concluded that marrow adipose tissue is an active endocrine organ with important metabolic functions contributing to bone energy maintenance, osteogenesis, bone remodeling, and hematopoiesis.
••
TL;DR: This study illustrates the use of metagenomic analysis to link the microbiome to bone phenotypes and provides preliminary findings implicating microbially synthesized vitamin-K as a regulator of bone matrix quality.
••
TL;DR: GIPR antagonism did not inhibit the GLP-2-induced reduction in bone resorption (CTX) in healthy young men and GIP increased P1NP despite decreasing CTX indicating an uncoupling of bone Resorption from formation.
••
TL;DR: It is demonstrated that CKD reduces bone quality, including microarchitecture and bone material properties, and that loss of bone quality with age is compounded by CKD, which may help reconcile why bone mass does not consistently predict fracture in the CKD population, as well as why older individuals with CKD are at high risk of fragility.
••
TL;DR: An overview is provided, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism.
••
TL;DR: Findings indicate that miR-93-5p slows OA progression partially by suppressing TCF4 expression, and this phenomenon may provide novel insights into the function of miRNA in OA.