Journal ArticleDOI
The genetics of vitamin D
TLDR
The genetic determinants of circulating vitamin D levels are reviewed by focusing on new findings from GWAS and WGS, as well as results from Mendelian randomization analyses conducted so far for vitamin D with various traits and diseases.About:
This article is published in Bone.The article was published on 2019-09-01. It has received 46 citations till now. The article focuses on the topics: vitamin D deficiency & Vitamin D and neurology.read more
Citations
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Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Xia Jiang,Xia Jiang,Paul F. O'Reilly,Hugues Aschard,Hugues Aschard,Yi-Hsiang Hsu,Yi-Hsiang Hsu,J. Brent Richards,Josée Dupuis,Josée Dupuis,Erik Ingelsson,Erik Ingelsson,David Karasik,Stefan Pilz,Diane J. Berry,Bryan Kestenbaum,Ju-Sheng Zheng,Jian'an Luan,Eleni Sofianopoulou,Elizabeth A. Streeten,Demetrius Albanes,Pamela L. Lutsey,Lu Yao,Weihong Tang,Michael J. Econs,Henri Wallaschofski,Henry Völzke,Ang Zhou,Chris Power,Mark I. McCarthy,Erin D. Michos,Eric Boerwinkle,Stephanie J. Weinstein,Neal D. Freedman,Wen-Yi Huang,Natasja M. van Schoor,Nathalie van der Velde,Nathalie van der Velde,Lisette C. P. G. M. de Groot,Anke W. Enneman,L. Adrienne Cupples,L. Adrienne Cupples,Sarah L. Booth,Ramachandran S. Vasan,Ching-Ti Liu,Yanhua Zhou,Samuli Ripatti,Claes Ohlsson,Liesbeth Vandenput,Mattias Lorentzon,Johan G. Eriksson,M. Kyla Shea,Denise K. Houston,Stephen B. Kritchevsky,Yongmei Liu,Kurt Lohman,Luigi Ferrucci,Munro Peacock,Christian Gieger,Marian Beekman,Eline Slagboom,Joris Deelen,Joris Deelen,Diana van Heemst,Marcus E. Kleber,Winfried März,Winfried März,Winfried März,Ian H. de Boer,Alexis C. Wood,Jerome I. Rotter,Stephen S. Rich,Cassianne Robinson-Cohen,Martin den Heijer,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Alana Cavadino,Alana Cavadino,Peter K. Joshi,James F. Wilson,Caroline Hayward,Lars Lind,Karl Michaëlsson,Stella Trompet,M. Carola Zillikens,André G. Uitterlinden,Fernando Rivadeneira,Linda Broer,Lina Zgaga,Harry Campbell,Evropi Theodoratou,Susan M. Farrington,Maria Timofeeva,Malcolm G. Dunlop,Ana M. Valdes,Ana M. Valdes,Emmi Tikkanen,Terho Lehtimäki,Leo-Pekka Lyytikäinen,Mika Kähönen,Olli T. Raitakari,Vera Mikkilä,M. Arfan Ikram,Naveed Sattar,J. Wouter Jukema,Nicholas J. Wareham,Claudia Langenberg,Nita G. Forouhi,Thomas E. Gundersen,Kay-Tee Khaw,Adam S. Butterworth,John Danesh,John Danesh,Tim D. Spector,Thomas J. Wang,Elina Hyppönen,Elina Hyppönen,Peter Kraft,Douglas P. Kiel,Douglas P. Kiel +119 more
TL;DR: The SUNLIGHT Consortium GWAS of serum 25-hydroxyvitamin D concentrations has identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, and CYP24A1) as mentioned in this paper.
Journal ArticleDOI
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
Joana A. Revez,Tian Lin,Zhen Qiao,Angli Xue,Yan Holtz,Zhihong Zhu,Jian Zeng,Huanwei Wang,Julia Sidorenko,Kathryn E. Kemper,Anna A. E. Vinkhuyzen,Julanne Frater,Darryl W. Eyles,Darryl W. Eyles,Thomas H. J. Burne,Thomas H. J. Burne,Brittany L. Mitchell,Brittany L. Mitchell,Nicholas G. Martin,Gu Zhu,Peter M. Visscher,Jian Yang,Jian Yang,Naomi R. Wray,John J. McGrath,John J. McGrath,John J. McGrath +26 more
TL;DR: A genome-wide association study of 25 hydroxyvitamin D concentration in 417,580 Europeans identifies 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD.
Journal ArticleDOI
Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials
TL;DR: New meta-analyses that include VITAL and other recent vitamin D trials indicate a significant reduction in cancer mortality but not in cancer incidence or CVD endpoints, and additional research is needed to determine which individuals may be most likely to derive a net benefit from vitamin D supplementation.
Journal ArticleDOI
Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response.
TL;DR: This mini-review focuses on the influence of VD and its serum levels on RA susceptibility, RA-associated complexities, treatment, and transcriptome products of key proinflammatory cytokines, along with other cytokines that are key regulators of inflammation in rheumatoid joints.
Journal ArticleDOI
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
Jue-Sheng Ong,Suzanne C. Dixon-Suen,Xikun Han,Xikun Han,Jiyuan An,Upekha E Liyanage,Jean-Cluade Dusingize,Johannes Schumacher,Ines Gockel,Anne Böhmer,Janusz Jankowski,Claire Palles,Tracy A. O'Mara,Amanda B. Spurdle,Matthew Law,Mark M. Iles,Paul Pharoah,Andrew Berchuck,Wei Zheng,Aaron P. Thrift,Aaron P. Thrift,Catherine M. Olsen,Rachel E. Neale,Puya Gharahkhani,Penelope M. Webb,Stuart MacGregor,Rebecca C. Fitzgerald,Matt Buas,Marilie D. Gammon,Douglas A. Corley,Nicholas J. Shaheen,Laura J. Hardie,Nigel C. Bird,Brian J. Reid,Wong-Ho Chow,Harvey A. Risch,Weimin Ye,Geoffrey Liu,Yvonne Romero,Leslie Bernstein,Anna H. Wu,David Whiteman,Thomas L. Vaughan,M. Agee,B. Alipanahi,A. Auton,R. K. Bell,K. Bryc,S. L. Elson,P. Fontanillas,N. A. Furlotte,David A. Hinds,K. E. Huber,A. Kleinman,N. K. Litterman,M. H. McIntyre,J. L. Mountain,E. S. Noblin,C. A. M. Northover,S. J. Pitts,J. Fah Sathirapongsasuti,O. V. Sazonova,J. F. Shelton,Suyash Shringarpure,C. Tian,J. Y. Tung,V. Vacic,C. H. Wilson +67 more
TL;DR: In this article, a unified Mendelian randomization (MR) analysis was performed to evaluate the relationship between 25-hydroxyvitamin D (25(OH)D) and 10 cancers.
References
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Journal ArticleDOI
LD score regression distinguishes confounding from polygenicity in genome-wide association studies :
Brendan Bulik-Sullivan,Po-Ru Loh,Hilary K. Finucane,Stephan Ripke,Jian Yang,Nick Patterson,Mark J. Daly,Alkes L. Price,Benjamin M. Neale +8 more
TL;DR: It is found that polygenicity accounts for the majority of the inflation in test statistics in many GWAS of large sample size, and the LD Score regression intercept can be used to estimate a more powerful and accurate correction factor than genomic control.
Journal ArticleDOI
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?
George Davey Smith,Shah Ebrahim +1 more
TL;DR: Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
Journal ArticleDOI
Partitioning heritability by functional annotation using genome-wide association summary statistics.
Hilary K. Finucane,Hilary K. Finucane,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Alexander Gusev,Gosia Trynka,Yakir A. Reshef,Po-Ru Loh,Verneri Anttila,Verneri Anttila,Han Xu,Chongzhi Zang,Kyle Kai-How Farh,Kyle Kai-How Farh,Stephan Ripke,Stephan Ripke,Felix R. Day,Shaun Purcell,Shaun Purcell,Eli A. Stahl,Sara Lindström,John R. B. Perry,Yukinori Okada,Soumya Raychaudhuri,Mark J. Daly,Mark J. Daly,Nick Patterson,Benjamin M. Neale,Benjamin M. Neale,Alkes L. Price,Alkes L. Price +30 more
TL;DR: A new method is introduced, stratified LD score regression, for partitioning heritability from GWAS summary statistics while accounting for linked markers, which is computationally tractable at very large sample sizes and leverages genome-wide information.
Journal ArticleDOI
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Thomas J. Wang,Feng Zhang,J. Brent Richards,Bryan Kestenbaum,Joyce B. J. van Meurs,Diane J. Berry,Douglas P. Kiel,Elizabeth A. Streeten,Claes Ohlsson,Daniel L. Koller,Leena Peltonen,Leena Peltonen,Jason D. Cooper,Paul F. O'Reilly,Denise K. Houston,Nicole L. Glazer,Liesbeth Vandenput,Munro Peacock,Julia Shi,Fernando Rivadeneira,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Pouta Anneli,Ian H. de Boer,Massimo Mangino,Bernet S. Kato,Deborah J. Smyth,Sarah L. Booth,Paul F. Jacques,Greg L. Burke,Mark O. Goodarzi,Ching-Lung Cheung,Myles Wolf,Kenneth Rice,David Goltzman,Nick Hidiroglou,Martin Ladouceur,Nicholas J. Wareham,Lynne J. Hocking,Deborah J. Hart,Nigel K Arden,Cyrus Cooper,Suneil Malik,William D. Fraser,Anna Liisa Hartikainen,Guangju Zhai,Helen M. Macdonald,Nita G. Forouhi,Ruth J. F. Loos,David M. Reid,Alan Hakim,Elaine M. Dennison,Yongmei Liu,Chris Power,Helen Stevens,Laitinen Jaana,Ramachandran S. Vasan,Nicole Soranzo,Nicole Soranzo,Jörg Bojunga,Bruce M. Psaty,Mattias Lorentzon,Tatiana Foroud,Tamara B. Harris,Albert Hofman,John-Olov Jansson,Jane A. Cauley,André G. Uitterlinden,Quince Gibson,Marjo-Riitta Järvelin,David Karasik,David S. Siscovick,Michael J. Econs,Stephen B. Kritchevsky,Jose C. Florez,John A. Todd,Josée Dupuis,Elina Hyppönen,Tim D. Spector +79 more
TL;DR: In this article, a genome-wide association study of 25-hydroxyvitamin D concentrations in 33,996 individuals of European descent from 15 cohorts was conducted to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.
Journal ArticleDOI
Current Understanding of the Molecular Actions of Vitamin D
TL;DR: This review raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout.
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