Journal ArticleDOI
The Genetic Architecture of Osteoporosis and Fracture Risk
TLDR
A general overview of the existing GWAS studies on osteoporosis traits and fracture risk is provided to provide an overview of several of the pathways identified by the GWAS efforts correspond to pathways that are currently targeted for the treatment of osteopOrosis.About:
This article is published in Bone.The article was published on 2019-09-01. It has received 91 citations till now. The article focuses on the topics: Osteoporosis.read more
Citations
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Journal ArticleDOI
Medical Treatment for Osteoporosis: From Molecular to Clinical Opinions
Li-Ru Chen,Nai-Yu Ko,Kuo-Hu Chen +2 more
TL;DR: This review, which is based on a systematic appraisal of the current literature, provides current molecular and genetic opinions on osteoporosis and its medical treatment and offers evidence-based information to help researchers and clinicians with osteopOrosis assessment.
Journal ArticleDOI
Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.
TL;DR: Wang et al. as mentioned in this paper summarized the discovery from genome-wide association studies (GWASs) in the bone field in the last 12 years and introduced the clinical use of GWAS findings in bone field, such as the identification of causal clinical risk factors, the development of drug targets and disease prediction.
Journal ArticleDOI
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.
David E. Place,R. K. Subbarao Malireddi,Jieun Kim,Peter Vogel,Masahiro Yamamoto,Thirumala-Devi Kanneganti +5 more
TL;DR: The authors showed that mice deficient in IFN signaling components including IFN alpha and beta receptor 1 (IFNAR1), interferon regulatory factor 1 (IRF1), IRF1, IRF9, and STAT1 each have reduced bone density and increased osteoclastogenesis compared to wild mice.
References
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Journal ArticleDOI
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
TL;DR: This Review highlights recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
Journal ArticleDOI
10 Years of GWAS Discovery: Biology, Function, and Translation
Peter M. Visscher,Naomi R. Wray,Qian Zhang,Pamela Sklar,Mark I. McCarthy,Matthew A. Brown,Jian Yang +6 more
TL;DR: The remarkable range of discoveriesGWASs has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics are reviewed.
Journal ArticleDOI
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Yaoqin Gong,R. B. Slee,Naomi Fukai,Georges Rawadi,Sergio Roman-Roman,Anthony M. Reginato,H. W. Wang,Tim Cundy,Francis H. Glorieux,Dorit Lev,M. Zacharin,Konrad Oexle,Jose Marcelino,Wafaa M. Suwairi,Shauna Heeger,G. Sabatakos,Suneel S. Apte,W. N. Adkins,J. Allgrove,M. Arslan-Kirchner,J. A. Batch,Peter Beighton,Graeme C.M. Black,R. G. Boles,L. M. Boon,C. Borrone,Han G. Brunner,G. F. Carle,Bruno Dallapiccola,A. De Paepe,B. Floege,M. L. Halfhide,Barbara Hall,Raoul C.M. Hennekam,Tatsuo Hirose,A. Jans,Harald Jüppner,Chong Ae Kim,K. Keppler-Noreuil,A. Kohlschuetter,Didier Lacombe,M. Lambert,E. Lemyre,T. Letteboer,Leena Peltonen,Rajkumar Ramesar,M. Romanengo,H. Somer,E. Steichen-Gersdorf,Beat Steinmann,Beth A. Sullivan,Andrea Superti-Furga,W. Swoboda,M. J. van den Boogaard,W. Van Hul,Miikka Vikkula,Marcela Votruba,Bernhard Zabel,Teresa Garcia,Roland Baron,Bjorn R. Olsen,Matthew L. Warman +61 more
TL;DR: It is reported that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth and is important for the establishment of peak bone mass.
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