Showing papers in "Fungal Genetics and Biology in 2011"

TL;DR: This review summarizes the current strategies that have been successfully applied during the last years to activate silent gene clusters in filamentous fungi, especially in the genus Aspergillus, and attempts to simulate the natural habitat by co-cultivation of microorganisms from the same ecosystem.

TL;DR: This review focuses on the role of secondary metabolism in driving antagonistic arthropod-fungus interactions, i.e., where fungi serve as a food source to fungal grazers, compete with saprophagous insects, and attack insects as hosts for growth and reproduction.

TL;DR: How fungi induce plant lipid metabolism to utilize plant oxylipins in order to promote G-protein-mediated regulation of sporulation and mycotoxin production in the fungus is described.

TL;DR: New findings suggest that SM clusters are silenced by heterochromatic histone marks and that the "closed" heterochrome structures are reversed during SM activation, mediated by the conserved activator of SM, LaeA.

TL;DR: This work provides a new and clearer understanding of how cells integrate secondary metabolism into basic cellular metabolism via the intra-cellular trafficking machinery.

TL;DR: Functional analyses of the TRI8 enzyme (Tri8) in F. graminearum revealed that differential activity of Tri8 determines the 3-ADON and 15-ADon chemotypes in Fusarium, and TRI3, which encodes a trichothecene carbon 15 acetyltransferase, was found to be functional in all three chemotypes.

TL;DR: GCPSR-based phylogenetic analyses of a 12-gene dataset provided strong support for the genealogical exclusivity of the Nepalese and Louisianan isolates, and both species are formally recognized herein as novel FGSC species.

TL;DR: The metabolic basis of C. albicans morphogenesis is reviewed and the role of primary metabolic pathways and quorum sensing molecules in the morphogenetic process is discussed, highlighting the metabolic pathways associated with the dimorphic transition and virulence.

TL;DR: The isolation and characterization of a new G. intraradicesNH(4)(+) transporter gene (GintAMT2) is reported and it is shown that GintAMMT2 encodes a functional NH(4](+) transporter.

TL;DR: This work describes how fungal pheromones are synthesized, their interactions with G protein-coupled receptors, and the signals propagated by this interaction, using Saccharomyces cerevisiae as a reference point.

TL;DR: Genome analysis suggests that in A. terreus the cis-aconitate decarboxylase gene is part of an itaconate acid related gene cluster including genes encoding two pathway specific transporters and a Zinc finger protein, and this cluster is directly linked to the large lovastatin gene cluster.

TL;DR: The genomes of 49 filamentous ascomycetes (subphylum Pezizomycotina) were examined by two independent methods and revealed that RIP-like activity varied greatly, both in extent of mutation and in dinucleotide context for C→T transitions.

TL;DR: Results suggest a difference in host preference among species of the FGSC, and it is hypothesize that F. graminearum may be less well adapted to infect maize ears than other members of theFGSC.

TL;DR: Although morel fruit bodies produce thousands of explosively discharged spores that are well suited to aerial dispersal, the results suggest that they are poorly adapted at invading novel niches.

TL;DR: In this article, the authors identify four loci involved in spore pigmentation of Aspergillus niger by using a combined genomic and classical complementation approach, and the loci whose mutation resulted in fawn, olive and brown color phenotypes were identified by complementation.

TL;DR: It is demonstrated that Pac1 negatively regulates Tri gene expression and toxin production in F. graminearum.

TL;DR: The results point to the significant role of tri5 in the production of trichodermin and in the antifungal activity of T. brevicompactum, a simple trichothecene-type toxin that shares the first steps of the sesquiterpene biosynthetic pathway with other phytotoxic trichoescenes from Fusarium spp.

TL;DR: Results indicate that different D MI fungicides target different CYP51 proteins in F. graminearum and that a mixture of DMI fungicides can result in synergistic effects, which have directly implications on chemical management strategies of plant diseases caused by Fusarium species.

TL;DR: ENV1 is suggested to connect the light response pathway with nutrient signaling by the heterotrimeric G-protein cascade by adjusting transcript levels of gna1 and gna3 and action on cAMP levels – presumably through inhibition of a phosphodiesterase.

TL;DR: It is shown that molecular dynamics simulations combined with site-directed mutagenesis of amino acid substitutions in the cyp51A gene, correlate to the structure-function relationship of the L98H substitution conferring to MAR in A. fumigatus.

TL;DR: Using this HSF1 CE2 deletion mutant, it is demonstrated that Hsf1 activation, and hence thermal adaptation, contributes significantly to the virulence of C. albicans.

TL;DR: Two biological datasets for Aspergillus fumigatus and Candida albicans were analyzed using FungiFun, providing an overview of the usage and functions of the tool.

TL;DR: AlbA is a predicted ortholog of alb1 from Aspergillus fumigatus which is responsible for production of the naphtho-γ-pyrone precursor for the 1,8-dihydroxynaphthalene (DHN) melanin/spore pigment.

TL;DR: It is demonstrated that FgATG15 is involved in fungal growth and aerial hyphae production and could be exploited as an antifungal target, and it is found that the deoxynivalenol levels of FgatG15 disruptants were significantly decreased compared with the wild type strain.

TL;DR: This study demonstrates that Cc.wc-2 is involved in blue light perception in this fungus, and finds that double-stranded RNA-mediated silencing of a ku70 homolog or the lig4 homolog greatly enhanced gene targeting.

TL;DR: OSCAR methodology combines PCR and Gateway® technology to rapidly and robustly generate precise deletion constructs for fungal ATMT and homologous gene replacement.

TL;DR: Although lipid synthesis was not affected by ACL deletion, histone acetylation was dramatically reduced in the ACL deletion mutants during sexual development, suggesting that the defects in sexual reproduction were caused by the reduction in histoneacetylation.

TL;DR: In conclusion, SSRs developed in this study were highly polymorphic and showed that T. melanosporum is a species with an important genetic diversity, which is in agreement with its recently uncovered heterothallic mating system.

TL;DR: It was found that cell budding was enhanced and mycelial formation was reduced in the disruptant, which confirms that Mig1, the transcriptional repressor, indeed regulates expression of the genes and production of the extracellular enzymes in S. fibuligera A11.

TL;DR: It is demonstrated that the fungal/plant chitinases do not have an essential role in the morphogenesis of A. fumigatus and may play only a nutritional role during this phase of the cycle, retarding fungal death.