Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe.
Javier J.M. Fernández,Verónica Prado,Jonel Trebicka,Alex Amoros,Thierry Gustot,Reiner Wiest,Carme Deulofeu,Elisabet Garcia,Juan Acevedo,Valentin Fuhrmann,François Durand,Cristina Sanchez,Mária Papp,Paolo Caraceni,Victor Vargas,Rafael Bañares,Salvatore Piano,Martin Janicko,Agustín Albillos,Carlo Alessandria,Germán Soriano,Tania M. Welzel,Wim Laleman,Alexander L. Gerbes,Andrea De Gottardi,Manuela Merli,Minneke J. Coenraad,Faouzi Saliba,Marco Pavesi,Rajiv Jalan,Pere Ginès,Paolo Angeli,Vicente Arroyo +32 more
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TLDR
MDR bacterial infections constitute a prevalent, growing and complex healthcare problem in patients with decompensated cirrhosis and acute-on-chronic liver failure across Europe, negatively impacting on prognosis and strategies aimed at preventing the spread of antibiotic resistance should be urgently evaluated.About:
This article is published in Journal of Hepatology.The article was published on 2019-03-01 and is currently open access. It has received 195 citations till now. The article focuses on the topics: Spontaneous bacterial peritonitis & Antibiotic resistance.read more
Citations
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Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases
Scott W. Biggins,Paulo Angeli,Guadalupe Garcia-Tsao,Pere Ginès,Simon C. Ling,Mitra K. Nadim,Florence Wong,W. Ray Kim +7 more
Journal ArticleDOI
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Jonel Trebicka,Javier Romaní Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Christian Jansen,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Peter Jarcuska,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,Debbie L. Shawcross,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Karen Vagner Danielsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Haluk Tarik Kani,Sven Francque,Stephen D. Ryder,Pierre Nahon,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia-Lopez,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Michael Praktiknjo,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,William Bernal,Ferran Aguilar,Joan Clària,Paola Ponzo,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Alexander L. Gerbes,Victor Vargas,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Richard Moreau,Paolo Angeli,Rajiv Jalan,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Maximilian J. Brol,Johannes Chang,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Martin Janicko,Daniel Markwardt,Mattias Mandorfer,Christoph Welsch,T.M. Welzel,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Flemming Bendtsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Joerg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Luise Aamann,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Harald Rupprechter,Cornelius Engelmann,Osman Ozdogan +130 more
TL;DR: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.
Journal ArticleDOI
Causes and Consequences of Innate Immune Dysfunction in Cirrhosis.
TL;DR: Knowledge of the phenotypic manifestation and pathophysiological mechanisms of cirrhosis associated immunosuppression may lead to immune targeted therapies to reduce susceptibility to infection in patients with Cirrhosis, and better biomarkers for risk stratification, and assessment of efficacy of novel immunotherapies.
Journal ArticleDOI
Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure
TL;DR: The gut microbiome is altered during development of liver cirrhosis, and these changes are associated with decompensation and development of acute-on-chronic liver failure (ACLF).
Journal ArticleDOI
Targeting the gut-liver-immune axis to treat cirrhosis.
TL;DR: In this article, established and emerging therapeutic strategies targeted at restoring intestinal eubiosis, augmenting gut barrier function and ameliorating the mucosal and systemic immune deficits that characterise and define the course of decompensated cirrhosis.
References
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
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Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
TL;DR: A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control and the Centers for Disease Control and Prevention, to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp.
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Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis
Richard Moreau,Rajiv Jalan,Pere Ginès,Marco Pavesi,Paolo Angeli,Juan Córdoba,François Durand,Thierry Gustot,Faouzi Saliba,Marco Domenicali,Alexander L. Gerbes,Julia Wendon,Carlo Alessandria,Wim Laleman,Stefan Zeuzem,Jonel Trebicka,Mauro Bernardi,Vicente Arroyo +17 more
TL;DR: Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Journal ArticleDOI
Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis
Vasiliki Arvaniti,Gennaro D'Amico,Giuseppe Fede,Pinelopi Manousou,Emmanuel Tsochatzis,M. Pleguezuelo,Andrew K. Burroughs +6 more
TL;DR: In patients with cirrhosis, infections increase mortality 4-fold; 30% of patients die within 1 month after infection and another 30% die by 1 year; prospects with prolonged follow-up evaluation and to evaluate preventative strategies are needed.
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