A map of the PPARα transcription regulatory network for primary human hepatocytes.
Patrick D. McMullen,Sudin Bhattacharya,Courtney G. Woods,Bin Sun,Kathy Yarborough,Susan M. Ross,Manda E. Miller,Mary McBride,Edward L. LeCluyse,Rebecca A. Clewell,Melvin E. Andersen +10 more
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TLDR
This work studied the signaling network for the peroxisome proliferator-associated receptor alpha (PPARα) in primary human hepatocytes using the selective PPARα ligand, GW7647 and developed two novel bioinformatics methods to visualize the dose-dependent activation of both the transcription factor circuitry for PPAR α and the downstream metabolic network in relation to functional annotation categories.About:
This article is published in Chemico-Biological Interactions.The article was published on 2014-02-25 and is currently open access. It has received 90 citations till now. The article focuses on the topics: Transcription factor & Nuclear receptor.read more
Citations
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Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease.
TL;DR: The transcriptional activation and repression mechanisms by PPAR α, the spectrum of target genes and chromatin-binding maps from recent genome-wide studies, are discussed, paying particular attention to PPARα-regulation of hepatic fatty acid and plasma lipoprotein metabolism during nutritional transition, and of the inflammatory response.
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Mitochondrial biogenesis and dynamics in the developing and diseased heart
TL;DR: The regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts are described.
Journal ArticleDOI
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
Barbara A. Wetmore,John F. Wambaugh,Brittany Allen,Stephen S. Ferguson,Mark A. Sochaski,R. Woodrow Setzer,Keith A. Houck,Cory L. Strope,Katherine E. Cantwell,Richard S. Judson,Edward L. LeCluyse,Harvey J. Clewell,Russell S. Thomas,Russell S. Thomas,Melvin E. Andersen +14 more
TL;DR: In this study, in vitro hepatic clearance and plasma protein binding were measured to estimate OEDs for a subset of Phase II chemicals and high-throughput exposure predictions generated using probabilistic modeling and Bayesian approaches generated by the U.S. Environmental Protection Agency (EPA) ExpoCast program were provided.
Journal ArticleDOI
Toxicity Testing in the 21st Century: Progress in the Past Decade and Future Perspectives
Daniel Krewski,Melvin E. Andersen,M. G. Tyshenko,K. Krishnan,Thomas Hartung,Thomas Hartung,Kim Boekelheide,John F. Wambaugh,D. Jones,Maurice Whelan,Russell S. Thomas,Carole L. Yauk,Tara S. Barton-Maclaren,Ila Cote +13 more
TL;DR: Overall, progress on the 20-year transition plan laid out by the US NRC in 2007 has been substantial and government agencies within the United States and internationally are beginning to incorporate the new approach methodologies envisaged in the original TT21C vision into regulatory practice.
Journal ArticleDOI
Skeletal muscle mitochondrial remodeling in exercise and diseases
TL;DR: The current state of knowledge relevant to the dynamic remodeling of skeletal muscle mitochondria in response to exercise and in disease states is reviewed.
References
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Yoav Benjamini,Yosef Hochberg +1 more
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TL;DR: Burrows-Wheeler Alignment tool (BWA) is implemented, a new read alignment package that is based on backward search with Burrows–Wheeler Transform (BWT), to efficiently align short sequencing reads against a large reference sequence such as the human genome, allowing mismatches and gaps.
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MEME Suite: tools for motif discovery and searching
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