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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).Abstract:
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For thisread more
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Caffeine induces a profound and persistent tachycardia in response to MDMA ("Ecstasy") administration.
TL;DR: Caffeine promotes hyperthermia and lethality when co-administered with the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") to rats, suggesting that central and sympathomimetic actions are responsible for the tachycardia observed in vivo.
Journal ArticleDOI
Caffeine is a risk factor for osteopenia of prematurity in preterm infants: a cohort study
Ebtihal Ali,Ebtihal Ali,Cheryl Rockman-Greenberg,Cheryl Rockman-Greenberg,Michael E. K. Moffatt,Michael E. K. Moffatt,Michael Narvey,Michael Narvey,Martin J. Reed,Depeng Jiang +9 more
TL;DR: Caffeine dose and duration of therapy of caffeine, as well as steroid are associated with osteopenia of prematurity in this cohort and future studies are needed to confirm these findings and determine the lowest dose of caffeine needed to treat effectively apnea ofPrematurity.
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Ion Channel Pharmacology for Pain Modulation.
TL;DR: The implications of some ion channels in pain transduction and the preclinical and clinical investigations on drugs that target such channels inPain studies are reviewed.
Journal ArticleDOI
Caffeine alters resting-state functional connectivity measured by blood oxygenation level-dependent MRI.
TL;DR: Per‐subject data analysis showed that caffeine decreased functional connectivity in the motor/visual cortices, but its effects on DMN varied among subjects, and correlation analysis of the changes in functional connectivity and regional blood flow suggested that the effect of caffeine on BOLD functional connectivity was predominantly neural (motor/ visual cortices) and partly vascular (DMN).
Journal ArticleDOI
Caffeine supplementation and reactive agility in elite youth soccer players
TL;DR: Caffeine supplementation may provide ergogenic benefit to elite, male, youth soccer players.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Journal ArticleDOI
A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.