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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use

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TLDR
Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).
Abstract
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For this

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Citations
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Caffeine discontinuation improves acute migraine treatment: a prospective clinic-based study

TL;DR: Caffeine abstinence is associated with better efficacy of acute migraine treatment, and this results encourage a further confirmatory study on this issue.
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Central dopaminergic neurotransmission plays an important role in thermoregulation and performance during endurance exercise.

TL;DR: Dopamine has been shown to have ergogenic effects and increase heat storage and hyperthermia tolerance, and the mechanisms underlying these effects seem to involve limiting/overriding the inhibitory signals from the central nervous system that result in cessation of exercise due tohyperthermia.
Journal Article

[Caffeine--common ingredient in a diet and its influence on human health].

TL;DR: It is underline that caffeine content in coffee and tea beverages varies greatly depending on the method of brewing whereas the content of caffeine in many brands of energy drinks can much vary, which should be taken into account in the daily caffeine intake.
Journal ArticleDOI

The Effects of Supplementation with a Vitamin and Mineral Complex with Guaraná Prior to Fasted Exercise on Affect, Exertion, Cognitive Performance, and Substrate Metabolism: A Randomized Controlled Trial

TL;DR: It is demonstrated that consuming a vitamin and mineral complex containing guaraná, prior to exercise, can positively impact subsequent memory performance and reduce perceived exertion during a moderate-intensity run in active males.
Journal ArticleDOI

Acute effects of caffeine supplementation on cortical arousal, anxiety, physiological response and marksmanship in close quarter combat

TL;DR: According to the previous literature, the ingestion of caffeine could help soldiers in operations conducted in sleep deprivation conditions, but in stressful combat situations it does not improve the marksmanship of soldiers.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Journal ArticleDOI

A Neural Substrate of Prediction and Reward

TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
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Trending Questions (1)
Does caffeine consumption limit the blood supply to the brain?

No, caffeine consumption does not limit the blood supply to the brain.