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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).Abstract:
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For thisread more
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Central excitability does not limit postfatigue voluntary activation of quadriceps femoris
J. M. Kalmar,E. Cafarelli +1 more
TL;DR: Caffeine-induced increase in central excitability was not associated with enhanced maximal voluntary activation during fatigue or recovery, demonstrating that voluntary activation is not limited by central excitable.
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Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and beta-alanine before exercise delays fatigue while improving reaction time and muscular endurance
Brandon D. Spradley,Kristy R Crowley,Chih-Yin Tai,Kristina L. Kendall,David H. Fukuda,Enrico N. Esposito,Sarah E Moon,Jordan R. Moon +7 more
TL;DR: Ingesting the SUP before exercise significantly improved agility choice reaction performance and lower body muscular endurance, while increasing perceived energy and reducing subjective fatigue, suggest that the SUP may delay fatigue during strenuous exercise.
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Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise.
TL;DR: Caffeine (equal to approximately 2 cups of brewed coffee) could produce a large reduction in pain resulting from eccentric exercise-induced, delayed-onset muscle injury, which may improve the quality of life of individuals who experience skeletal muscle pain after engaging in unaccustomed, eccentrically biased exercise.
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The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors.
Linda Halldner,Ulrika Ådén,Viktoria Dahlberg,Björn Johansson,Catherine Ledent,Bertil B. Fredholm +5 more
TL;DR: The results suggest that the inhibitory effect of high doses of caffeine is due neither to blockade of the A1R, nor ofThe A2AR, and an effect independent of these adenosine receptors is likely.
Journal ArticleDOI
Effects of caffeine in non-withdrawn volunteers
TL;DR: Using participants who had consumed their normal daily quota of caffeine this study alleviated this potential confound as all participants were not withdrawn at the time of testing.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
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A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.